A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches
Cancers,
Год журнала:
2025,
Номер
17(2), С. 257 - 257
Опубликована: Янв. 14, 2025
As
cells
divide,
telomeres
shorten
through
a
phenomenon
known
as
telomere
attrition,
which
leads
to
unavoidable
senescence
of
cells.
Unprotected
DNA
exponentially
increases
the
odds
mutations,
can
evolve
into
premature
aging
disorders
and
tumorigenesis.
There
has
been
growing
academic
clinical
interest
in
exploring
this
duality
developing
optimal
therapeutic
strategies
combat
attrition
cellular
immortality
cancer.
The
purpose
review
is
provide
an
updated
overview
biology
tactics
address
We
used
Rayyan
platform
PubMed
database
examined
ClinicalTrial.gov
registry
gain
insight
trials
their
results.
Cancer
activate
telomerase
or
utilize
alternative
lengthening
escape
shortening,
leading
near
immortality.
Contrarily,
normal
experience
telomeric
erosion,
contributing
disorders,
such
Werner
syndrome
Hutchinson-Gilford
Progeria,
(2)
aging-related
diseases,
neurodegenerative
cardiovascular
diseases.
literature
presents
several
promising
approaches
potentially
balance
maintenance
shortening
This
highlights
gaps
knowledge
points
potential
these
interventions
preclinical
studies
inform
future
research
cancer
aging.
Язык: Английский
The Genetic and Epigenetic Arms of Human Ageing and Longevity
Biology,
Год журнала:
2025,
Номер
14(1), С. 92 - 92
Опубликована: Янв. 18, 2025
This
proposed
review
aims
to
shed
light
on
the
major
genetic
and
epigenetic
contributions
ageing
process
longevity
of
individuals.
In
this
context,
we
summarize
state
knowledge
most
important
variants,
their
interactions
with
environment,
in
achieving
a
healthy
lifespan.
We
also
explore
contribution
lifestyle
influence
non-heritable
environmental
factors
(i.e.,
epigenetics).
Accordingly,
discuss
role
inflammageing
as
one
targets
overcome
morbidity
mortality
older
people
for
maintenance
ageing.
more
integrated
view
will
display
not
only
underlying
mechanisms
at
play
but
invites
reader
rethink
both
our
attitudes
toward
age.
Язык: Английский
Resetting the aging clock through epigenetic reprogramming: Insights from natural products
Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
unknown, С. 108850 - 108850
Опубликована: Апрель 1, 2025
Язык: Английский
Common features between aging and cancer: a narrative review
Aging advances.,
Год журнала:
2024,
Номер
1(2), С. 118 - 134
Опубликована: Дек. 1, 2024
Aging
is
a
complex
biological
process
characterized
by
gradual
deterioration
in
physiological
activities,
contributing
to
an
elevated
risk
of
different
age-associated
malignancies,
including
cancer.
The
current
review
paper
aims
elucidate
the
association
between
hallmarks
aging
and
parallel
development
Various
cellular
molecular
mechanisms
underlying
such
as
senescence,
genomic
instability,
telomere
shortening
play
significant
role
accumulation
genetic
mutations
disruption
activities.
It
has
also
discussed
immune
system’s
aging,
indicating
how
age-linked
dysfunction
compromises
body’s
capacity
recognize
eradicate
pre-tumorous
cells,
thus
promoting
cancer
advancement.
This
examines
affects
tumor
microenvironment,
where
age-related
alterations
stromal
extracellular
matrix
factors
lead
conditions
that
promote
growth
proliferation.
Furthermore,
it
discusses
concept
“accelerated
aging”
survivors,
highlighting
negative
effects
its
therapy
intensify
process,
resulting
greater
physical
cognitive
decline.
explores
prospect
new
therapies
target
aging-related
processes
ameliorate
outcomes.
Overall,
underscores
need
for
ongoing
interdisciplinary
research
understand
relationship
cancer,
ultimately
aiming
develop
more
effective
prevention
treatment
approaches.
Язык: Английский
Interdependence between Nuclear Pore Gatekeepers and Genome Caretakers: Cues from Genome Instability Syndromes
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9387 - 9387
Опубликована: Авг. 29, 2024
This
review
starts
off
with
the
first
germline
homozygous
variants
of
Nucleoporin
98
gene
(NUP98)
in
siblings
whose
clinical
presentation
recalls
Rothmund–Thomson
(RTS)
and
Werner
(WS)
syndromes.
The
progeroid
phenotype
caused
by
a
associated
haematological
malignancies
neurodegenerative
disorders
primed
search
for
interplay
between
caretakers
involved
genome
instability
syndromes
Nuclear
Pore
Complex
(NPC)
components.
In
context
basic
information
on
NPC
architecture
functions,
we
discuss
studies
interdependence
gatekeepers
WS
Hereditary
Fibrosing
Poikiloderma
(POIKTMP),
both
entering
differential
diagnosis
RTS.
WS,
WRN/WRNIP
complex
interacts
nucleoporins
Y-complex
NDC1
altering
architecture.
POIKTMP,
mutated
FAM111B,
recruited
Y-complex’s
SEC13
NUP96,
several
Nups
safeguarding
structure.
linkage
defective
to
highlights
attempt
activate
repair
hub
at
nuclear
periphery
restore
DNA
damage.
two
separate
POIKTMP
are
drawn
close
interaction
their
damage
sensors
shared
hallmark
short
fragile
telomeres
disclosing
major
role
telomere
maintenance.
Язык: Английский
Progeroid Cockayne Syndrome
Вопросы современной педиатрии,
Год журнала:
2024,
Номер
23(3), С. 124 - 130
Опубликована: Июль 10, 2024
Cockayne
syndrome
is
a
rare
genetic
disease
from
the
group
of
premature
aging
syndromes
associated
with
impaired
DNA
repair.
The
autosomal
recessive,
and
it
caused
by
pathogenic
variants
in
ERCC8,
ERCC6,
XPB
(ERCC3),
XPD
(ERCC2),
XPG
(ERCC5)
genes.
Its
prevalence
1
case
per
2.5
million
people.
clinical
signs
include
nervous,
cardiovascular
musculoskeletal
systems
impairments,
severe
growth
retardation,
body
weight
deficiency.
average
life
expectancy
these
patients
varies
5
to
30
years
depends
on
type
severity.
There
no
pathogenetic
treatment.
This
article
presents
results
latest
research
diagnosis
management.
Язык: Английский