Advances in biochemistry in health and disease, Год журнала: 2024, Номер unknown, С. 285 - 303
Опубликована: Янв. 1, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102521 - 102521
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
9
Neuron, Год журнала: 2025, Номер 113(1), С. 109 - 126
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
ABSTRACT Aging is a natural process characterized by progressive physiological decline that undermines health and well-being in the elderly population. It widely accepted an unbalanced redox state belongs to hallmarks of aging, but its role as one main drivers ferroptosis quite recent. Ferroptosis form iron-dependent cell death caused massive phospholipid peroxidation. The excessive accumulation intracellular reactive oxygen species iron, well failure cellular antioxidant systems, cause ferroptotic death. While clear roles for pathological conditions such cancer or neurodegeneration have been described, regulators are less clearly understood. Here, using Caenorhabditis elegans powerful model organism aging studies, we uncover mediated disturbed homeostasis. We evaluated healthspan parameters C. wild-type strain highlighting how several age-related features differentially during aging. A loss capability contrast external stressors, with increase hydroxyl radicals glutathione system demonstrated disruption homeostasis older age. Moreover, showed selected genes involved metabolism downregulated Among them, mutant strains fatty acyl-CoA reductase, fard-1 , dehydrogenase, dhs-25 displayed higher sensitivity inducer, increased lipid peroxidation, anticipated drop total reduced lifespan. Accordingly, expression closest mammalians homolog, hydroxysteroid 17-Beta Dehydrogenase 8, was cells which more sensitive ferroptosis. Our results prove causal driven oxidative stress, unveiling novel this connection may constitute targets possible interventions improve healthy
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7122 - 7122
Опубликована: Июнь 28, 2024
The notion of notable anatomical, biochemical, and behavioral distinctions within male female brains has been a contentious topic interest the scientific community over several decades. Advancements in neuroimaging molecular biological techniques have increasingly elucidated common mechanisms characterizing brain aging while also revealing disparities between sexes these processes. Variations cognitive functions; susceptibility to progression neurodegenerative conditions, notably Alzheimer’s Parkinson’s diseases; life expectancy sexes, underscore significance evaluating framework gender differences. This comprehensive review surveys contemporary literature on restructuring structures fundamental processes unfolding at cellular levels, with focus distinctions. Additionally, delves into age-related alterations, exploring factors influencing acceleration or deceleration aging, particular attention estrogen’s hormonal support central nervous system.
Язык: Английский
Процитировано
4
Medicina, Год журнала: 2024, Номер 60(10), С. 1647 - 1647
Опубликована: Окт. 8, 2024
The most prevalent reason for vision impairment in aging inhabitants is age-related macular degeneration (AMD), a posterior ocular disease with poor understanding of the anatomic, genetic, and pathophysiological progression disease. Recently, new insights exploring role atrophic changes retinal pigment epithelium, extracellular drusen deposits, lysosomal lipofuscin, various genes have been investigated AMD. Hence, this review explores incidence risk factors AMD, such as oxidative stress, inflammation, complement system, involvement bioactive lipids their angiogenesis. In addition to intravitreal anti-vascular endothelial growth factor (VEGF) therapy other therapeutic interventions oral kinase inhibitors, photodynamic, gene, antioxidant therapy, well benefits drawbacks AMD treatment options, strategic drug delivery methods, including routes focus on pharmacokinetics, are investigated. Further, recent advancements nanoformulations polymeric lipid nanocarriers, liposomes, etc., intended pros cons too summarized. Therefore, purpose give researchers an pathophysiology, emphasis angiogenesis, function lipids, options. Additionally, options that development system(s) via several can aid advancement choices.
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 671 - 671
Опубликована: Янв. 14, 2025
Human hematopoietic stem cells (HSCs) have traditionally been viewed as self-renewing, multipotent with enormous potential in sustaining essential steady state blood and immune cell production throughout life. Indeed, around 86% (1011-1012) of new generated daily a healthy young human adult are origin. Therapeutically, HSCs contributed to over 1.5 million transplants (HCTs) globally, making this the most successful regenerative therapy date. We will commence review by briefly highlighting selected key achievements (from 1868 end 20th century) that accomplishment. Much our knowledge hematopoiesis is based on small animal models that, despite their importance, do not always recapitulate hematopoiesis. Given this, we critically progress challenges faced identifying tracing lineage differentiation trajectories, referring murine studies needed. Moving forward given dynamic can readily adjust variety stressors, then discuss recent research advances contributing understanding (i) which HSPCs maintain hematopoiesis, (ii) where these located, (iii) mechanisms come into play when homeostatic switches stress-induced or emergency
Язык: Английский
Процитировано
0
Geriatric Care, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 22, 2025
In this narrative review, we analyzed the existing literature on pros and cons of anticholinergic medications, focusing their prevalence, underlying mechanisms, methods assessment. Our review underscores significant adverse effects drugs, particularly cognition functional abilities in older adults. These include exacerbation various cognitive states, increased psychiatric symptoms, heightened risk delirium, decline, elevated hospitalization rates, greater likelihood institutionalization, mortality. While medications provide therapeutic benefits, use adults requires careful evaluation due to these considerable risks. Discontinuation therapy offers both benefits challenges. We propose practical guidelines for clinical contexts such as dementia, schizophrenia, depression, anxiety, Parkinson’s disease, cardiovascular conditions, urinary incontinence.
Язык: Английский
Процитировано
0
Cosmetics, Год журнала: 2025, Номер 12(1), С. 28 - 28
Опубликована: Фев. 8, 2025
Body image, a complex interplay of perceptions, thoughts, and feelings about one’s physical appearance, has been subject extensive research. It is dynamic construct that evolves throughout woman’s lifespan, influenced by multitude biological, psychological, sociocultural factors. From adolescence, marked the onset puberty societal pressures to conform specific beauty standards, adulthood changes associated with aging, women’s body image undergoes significant transformations. Aging universal process affects all organs, including female genitalia. The vaginal tract atrophy due declining estrogen levels, particularly during after menopause. Aesthetic gynecology offers range procedures address both functional aesthetic concerns related aging gynecology, burgeoning field within health, provides various aimed at enhancing genital appearance function. also helps balance hormonal anatomical every woman experiences over time. goal strengthen each patient’s intimate well-being self-esteem, enabling them experience intimacy peacefully. While often driven attractiveness sexual satisfaction, psychological implications these are multifaceted. crucial recognize between factors decision undergo procedures. Collaboration surgeons mental health professionals can ensure candidates psychologically prepared have realistic expectations. By adopting patient-centered approach conducting rigorous research, healthcare providers used as tool for empowerment rather than exploitation. This article explores intricate relationship examining how impact overall quality life.
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102733 - 102733
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Expert Review of Respiratory Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 13, 2025
Chronic obstructive pulmonary disease (COPD) is progressive in nature and predominantly affects older individuals. Lung function decline a typical part of the aging process, characterized by gradual loss lung mechanics, airway remodeling, persistent low-grade inflammation airways, compromised epithelial barrier function, impaired immune responses over time. The pathology senile advanced patients with COPD, whereby genomic damages contribute to structural defects cellular dysfunction. Primary, antagonistic integrative hallmarks are accelerated potentiated cumulative injury sustained from repeated environmental exposures interaction comorbidities. Identification epigenetic profiles COPD indicates how processes advancement biological age. Epigenetic abnormalities unique subpopulations occur individuals who immunodeficient, often experience early onset increased severity COPD. Accelerated indicated other biomarkers may be promising avenue for detection, prevention, subsequent management Understanding risk factors contributing implementation mitigation strategies such as cessation smoking, repurposing existing pharmacotherapeutics development novel therapies slow age-related pathologies
Язык: Английский
Процитировано
0