Morphopathology of the lesions induced by SARS-CoV-2 infection in the lungs DOI Open Access

Florin Ionuț Buibaș,

Roberta Andreea Cercel,

Mircea-Sebastian Șerbănescu

и другие.

Romanian Journal of Morphology and Embryology, Год журнала: 2025, Номер 65(4), С. 637 - 645

Опубликована: Фев. 13, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spread rapidly from China around the world, causing worst pandemic since beginning of 21st century. Although disease named 2019 (COVID-19) has multiple organ symptoms, main pathological lesions occur in lung, failure, pulmonary embolism, secondary bacterial pneumonia and fibrosis. Despite best efforts researchers, pathogenesis SARS-CoV-2-induced cellular tissue damage organs systems is poorly understood. Therefore, our study, we aimed to highlight their extent, which could explain complex symptomatology presented by patients who died with distress (ARDS). The study was performed on a number 36 diagnosed COVID-19 under legally suspicious conditions, requiring autopsy within Romanian Forensic Medicine Institutes. All local inflammatory reaction pneumonic type, exudative proliferative phenomena, intra-alveolar interstitial infiltrates formed lymphocytes, macrophages neutrophilic granulocytes, congested or ruptured blood vessels hemorrhages, thrombosis, proliferation fibroblasts transformed into myofibroblasts presence granulation that remodeled entire lung parenchyma.

Язык: Английский

Morphopathology of the lesions induced by SARS-CoV-2 infection in the lungs DOI Open Access

Florin Ionuț Buibaș,

Roberta Andreea Cercel,

Mircea-Sebastian Șerbănescu

и другие.

Romanian Journal of Morphology and Embryology, Год журнала: 2025, Номер 65(4), С. 637 - 645

Опубликована: Фев. 13, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spread rapidly from China around the world, causing worst pandemic since beginning of 21st century. Although disease named 2019 (COVID-19) has multiple organ symptoms, main pathological lesions occur in lung, failure, pulmonary embolism, secondary bacterial pneumonia and fibrosis. Despite best efforts researchers, pathogenesis SARS-CoV-2-induced cellular tissue damage organs systems is poorly understood. Therefore, our study, we aimed to highlight their extent, which could explain complex symptomatology presented by patients who died with distress (ARDS). The study was performed on a number 36 diagnosed COVID-19 under legally suspicious conditions, requiring autopsy within Romanian Forensic Medicine Institutes. All local inflammatory reaction pneumonic type, exudative proliferative phenomena, intra-alveolar interstitial infiltrates formed lymphocytes, macrophages neutrophilic granulocytes, congested or ruptured blood vessels hemorrhages, thrombosis, proliferation fibroblasts transformed into myofibroblasts presence granulation that remodeled entire lung parenchyma.

Язык: Английский

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