Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 788 - 788
Опубликована: Июнь 16, 2024
The
COVID-19
pandemic,
caused
by
infection
with
the
SARS-CoV-2
virus,
is
associated
cognitive
impairment
and
Alzheimer’s
disease
(AD)
progression.
Once
it
enters
brain,
virus
stimulates
accumulation
of
amyloids
in
brain
that
are
highly
toxic
to
neural
cells.
These
may
trigger
neurological
symptoms
COVID-19.
meningeal
lymphatic
vessels
(MLVs)
play
an
important
role
removal
toxins
mediate
viral
drainage
from
brain.
MLVs
considered
a
promising
target
prevent
COVID-19-exacerbated
dementia.
However,
there
limited
methods
for
augmentation
MLV
function.
This
review
highlights
new
discoveries
field
COVID-19-mediated
amyloid
development
strategies
stimulate
clearance
through
other
pathways.
based
on
innovative
treating
dysfunction
induced
infection,
including
use
photobiomodulation,
plasmalogens,
medicinal
herbs,
which
offer
hope
addressing
challenges
posed
virus.
Язык: Английский
Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Many
coronavirus
disease
2019
(COVID-19)
positive
individuals
exhibit
abnormal
electroencephalographic
(EEG)
activity
reflecting
"brain
fog"
and
mild
cognitive
impairments
even
months
after
the
acute
phase
of
infection.
Resting-state
EEG
abnormalities
include
slowing
(reduced
alpha
rhythm;
increased
slow
waves)
epileptiform
activity.
An
expert
panel
conducted
a
systematic
review
to
present
compelling
evidence
that
deficits
due
COVID-19
Alzheimer's
related
dementia
(ADRD)
are
driven
by
overlapping
pathologies
neurophysiological
abnormalities.
seen
in
patients
resemble
those
observed
early
stages
neurodegenerative
diseases,
particularly
ADRD.
It
is
proposed
similar
Long
COVID
ADRD
parallel
neuroinflammation,
astrocyte
reactivity,
hypoxia,
neurovascular
injury.
These
underpinning
decline
can
be
detected
routine
exams.
Future
research
will
explore
value
monitoring
for
predicting
long-term
outcomes
efficacy
therapeutic
interventions.
HIGHLIGHTS:
Abnormal
intrinsic
electrophysiological
brain
activity,
such
as
EEG,
reduced
wave,
characteristic
findings
patients.
have
potential
neural
biomarkers
identify
neurological
complications
at
stage
disease,
assist
clinical
assessment,
assess
risk
Similar
typically
with
impairments,
Evidence
presented
supports
idea
resulting,
least
part,
from
neuroinflammatory
mechanisms
reactivity.
Identifying
common
biological
highlight
critical
underlying
disorders
decline.
elucidates
questions
regarding
impairment
not
yet
been
adequately
investigated.
Язык: Английский
Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids
Exploration of neuroscience,
Год журнала:
2025,
Номер
4
Опубликована: Март 24, 2025
The
SAR-CoV-2
virus
has
evolved
to
co-exist
with
human
hosts,
albeit
at
a
substantial
energetic
cost
resulting
in
post-infection
neurological
manifestations
[Neuro-post-acute
sequelae
of
SARS-CoV-2
infection
(PASC)]
that
significantly
impact
public
health
and
economic
productivity
on
global
scale.
One
the
main
molecular
mechanisms
responsible
for
development
Neuro-PASC,
individuals
all
ages,
is
formation
inadequate
proteolysis/clearance
phase-separated
amyloid
crystalline
aggregates—a
hallmark
feature
aging-related
neurodegenerative
disorders.
Amyloidogenesis
during
viral
persistence
natural,
inevitable,
protective
defense
response
exacerbated
by
SARS-CoV-2.
Acting
as
chemical
catalyst,
accelerates
hydrophobic
collapse
heterogeneous
nucleation
amorphous
amyloids
into
stable
β-sheet
aggregates.
clearance
aggregates
most
effective
slow
wave
sleep,
when
high
levels
adenosine
triphosphate
(ATP)—a
biphasic
modulator
biomolecular
condensates—and
melatonin
are
available
solubilize
removal.
dysregulation
mitochondrial
dynamics
SARS-CoV-2,
particular
fusion
fission
homeostasis,
impairs
proper
distinct
subpopulations
can
remedy
challenges
created
diversion
substrates
away
from
oxidative
phosphorylation
towards
glycolysis
support
replication
maintenance.
subsequent
reduction
ATP
inhibition
synthesis
sleep
results
incomplete
brain
aggregates,
leading
commonly
associated
age-related
Exogenous
not
only
prevents
dysfunction
but
also
elevates
production,
effectively
augmenting
solubilizing
effect
moiety
ensure
timely,
optimal
disaggregation
pathogenic
prevention
attenuation
Neuro-PASC.
Язык: Английский
Amyloidogenesis of SARS-CoV-2 Delta Plus and Omicron Variants Receptor-Binding Domain (RBD): Impact of SUMO Fusion Tag
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 17, 2024
Abstract
Objectives
The
RBD
of
SARS-CoV-2
mediates
viral
entry
into
host
cells
by
binding
to
the
receptor
ACE2.
infection
is
linked
various
health
issues
resembling
amyloid-related
problems,
persuading
us
investigate
amyloidogenicity
spike
RBD.
FoldAmyloid
program
was
used
assess
amyloidogenic
propensities
in
Delta
Plus
and
Omicron
variant,
with
without
SUMO
tag.
After
expression
RBDs,
purification,
dialysis
steps
were
performed.
Subsequently,
ThT
assay,
FTIR,
TEM
employed
check
RBD's
ability
form
fibrils.
Results
TEM,
FTIR
revealed
self-assemble
β-sheet-rich
aggregates
(48.4%
β-sheet
content).
Additionally,
presence
tag
reduced
formation
amyloid-like
potential
higher
than
Plus,
according
both
in
silico
experimental
analyses.
Conclusions
can
assemble
itself
forming
containing
fibrils
a
significantly
decrease
In
analysis
suggested
that
variation
fluorescence
intensity
amyloid
accumulations
two
strains
arises
from
specific
mutations
their
regions.
Язык: Английский
Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12552 - 12552
Опубликована: Ноя. 22, 2024
Amyloid
beta
(Aβ)
is
a
neuronal
metabolic
product
that
plays
an
important
role
in
maintaining
brain
homeostasis.
Normally,
intensive
Aβ
formation
accompanied
by
its
effective
lymphatic
removal.
However,
the
excessive
accumulation
of
observed
with
age
and
during
development
Alzheimer's
disease
(AD)
leading
to
cognitive
impairment
memory
deficits.
There
emerging
evidence
plasmalogens
(Pls),
as
one
key
lipids,
may
be
beneficial
for
AD
aging.
Here,
we
studied
effects
Pls
on
functions
clearance
from
mice
different
ages.
The
results
showed
effectively
reduce
levels
facilitate
learning
aged
but
not
old
mice.
In
mice,
improve
increase
general
motor
activity
improvement
emotional
status
ability.
Thus,
these
findings
suggest
could
promising
candidate
alternative
or
concomitant
therapy
age-related
diseases
enhance
functions.
Язык: Английский
Amyloidogenesis of SARS-CoV-2 delta plus and omicron variants receptor-binding domain (RBD): impact of SUMO fusion tag
Biotechnology Letters,
Год журнала:
2024,
Номер
46(6), С. 1037 - 1048
Опубликована: Авг. 25, 2024
Язык: Английский
Exploring the Potential Long-term Impact of SARS-CoV-2 on Protein Misfolding and Amyloid-related Conditions
Protein and Peptide Letters,
Год журнала:
2024,
Номер
31(8), С. 602 - 610
Опубликована: Авг. 28, 2024
The
long-term
impact
of
the
COVID-19
pandemic
concerns
risk
to
human
health,
particularly
its
potential
association
with
protein
misfolding
and
amyloidosis.
This
review
article
explores
causality
relationship
between
SARS-CoV-2
infection,
misfolding,
leading
amyloid-related
conditions.
It
delves
into
mechanisms
by
which
viral
proteins
may
accelerate
amyloid
formation,
exacerbating
post-infection
complications,
including
neurological
sequelae.
Drawing
from
interdisciplinary
research
clinical
observations,
links
COVID-19,
vaccination,
amyloidosis,
emphasize
importance
understanding
longterm
effect
post-COVID
symptoms.
examines
role
COVID-19-related
in
formation
other
related
Язык: Английский
Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points Amid RET Pathogenic Variants in Medullary Thyroid Cancer/Multiple Endocrine Neoplasia Type 2 (MEN2)
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9765 - 9765
Опубликована: Сен. 10, 2024
We
aimed
to
provide
an
updated
narrative
review
with
respect
the
RET
pathogenic
variants
and
their
implications
at
clinical
molecular
level
in
diagnosis
of
medullary
thyroid
cancer
(MTC)/multiple
endocrine
neoplasia
(MEN)
type
2,
particularly
presence
cutaneous
lichen
amyloidosis
(CLA).
searched
English-language,
extenso
original
articles
no
timeline
nor
study
design
restriction
that
were
published
on
PubMed.
A
traditional
interplay
stands
for
CLA
MTC
MEN2
(not
MEN3)
confirmation.
While
connection
has
been
reported
more
than
three
decades,
there
is
still
a
large
gap
understanding
addressing
it.
The
majority
patients
MEN2A-CLA
have
codon
634;
hence,
it
suggests
involvement
this
specific
cysteine
residue
both
disorders
(most
data
agree
one-third
C634-positive
subjects
CLA,
but
ranges
are
between
9%
50%).
Females
seem
prone
MEN2-CLA
males.
Non-C634
germline
included
(at
low
statistical
evidence)
following:
V804M
mutation
exon
14
MTC-CLA
(CLA
upper
back);
S891A
15
binding
OSMR
variant
G513D
(familial
comprising
lower
legs
thighs,
back,
shoulders,
arms,
forearms);
C611Y
interscapular
region),
respectively.
Typically,
detected
early
age
(from
childhood
until
young
adulthood)
before
actual
identification
unless
screening
protocols
already
applied.
time
frame
was
5
60
years
according
one
study.
same
family
not
necessarily
associated
presentation.
In
MTC/MEN2
subjects,
most
affected
area
scapular
region
back.
Alternatively,
another
hypothesis
highlighted
fact
secondary
long-term
prurit/notalgia
paresthetica
(NP)
MTC/MEN2.
p.
may
play
role
modifying
evolutionary
processes
co-harboring
mutations
(further
studies
necessary
sustain
aspect).
Awareness
CLA-positive
essential,
including
decision
testing
selected
cases.
Язык: Английский