SFP6 fluorescent probes for imaging SAM dynamics in living cells
Microchimica Acta,
Год журнала:
2025,
Номер
192(3)
Опубликована: Фев. 21, 2025
Язык: Английский
Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response
Free Radical Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Association between methyl donor nutrients’ dietary intake with phenotypic aging among US adults: a cross-sectional study from NHANES 2005–2018
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
This
study
investigates
the
association
between
dietary
methyl
donor
nutrients
intake
and
phenotypic
aging.
cross-sectional
comprised
27,211
adult
participants
from
NHANES
2005-2018.
The
methyl-donor
nutritional
quality
index
(MNQI)
was
calculated
by
assessing
of
seven
nutrients:
protein,
folate,
choline,
riboflavin,
vitamin
B6,
B12,
zinc.
Phenotypic
age
acceleration
(PhenoAge.Accel)
using
biochemical
markers
to
assess
biological
Weighted
generalized
linear
regression
models
were
utilized
associations
MNQI
PhenoAge.Accel,
impact
different
demographic
health
characteristics
evaluated
through
interaction
effect
tests.
After
adjusting
for
various
potential
confounding
factors,
a
significant
negative
found
PhenoAge.Accel
(β
=
-
0.66;
95%
CI
0.91,
0.40;
P
<
0.0001),
indicating
that
an
increase
in
is
associated
with
slowdown
PhenoAge.Accel.
Furthermore,
subgroup
analysis
indicated
stronger
negatively
males
0.94;
1.36,
0.52)
interactions
(Pinteraction
0.02).
In
populations,
PhenoAge
Accel,
suggesting
choosing
high-quality
foods
can
help
develop
effective
strategies
enhance
healthy
longevity.
Язык: Английский
Associations between Circulating Biomarkers of One-Carbon Metabolism and Mitochondrial D-Loop Region Methylation Levels
Epigenomes,
Год журнала:
2024,
Номер
8(4), С. 38 - 38
Опубликована: Окт. 9, 2024
One-carbon
metabolism
is
a
critical
pathway
for
epigenetic
mechanisms.
Circulating
biomarkers
of
one-carbon
have
been
associated
with
changes
in
nuclear
DNA
methylation
levels
individuals
affected
by
age-related
diseases.
More
and
more
studies
are
showing
that
even
mitochondrial
(mtDNA)
could
be
methylated.
In
particular,
the
displacement
(D-loop)
region
modulates
gene
expression
replication
mtDNA
and,
when
altered,
can
contribute
to
development
human
illnesses.
However,
no
study
until
now
has
demonstrated
an
association
between
circulating
D-loop
levels.
Язык: Английский
The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1387 - 1387
Опубликована: Окт. 31, 2024
One-carbon
(1C)
metabolism
is
a
complex
network
of
metabolic
reactions
closely
related
to
producing
1C
units
(as
methyl
groups)
and
utilizing
them
for
different
anabolic
processes,
including
nucleotide
synthesis,
methylation,
protein
reductive
metabolism.
These
pathways
support
the
high
proliferative
rate
cancer
cells.
While
drugs
that
target
(like
methotrexate)
have
been
used
treatment,
they
often
significant
side
effects.
Therefore,
developing
new
with
minimal
effects
necessary
effective
treatment.
Methionine,
glycine,
serine
are
main
three
precursors
vital
not
only
cells
but
also
non-proliferative
in
regulating
energy
homeostasis
aging
process.
Understanding
potential
role
crucial
advancing
our
knowledge
neoplastic
progression.
This
review
provides
comprehensive
understanding
molecular
complexities
context
aging,
paving
way
researchers
explore
avenues
advanced
therapeutic
interventions
cancer.
Язык: Английский