Archives of Gerontology and Geriatrics Plus, Год журнала: 2024, Номер unknown, С. 100079 - 100079
Опубликована: Сен. 1, 2024
Язык: Английский
Frontiers in Toxicology, Год журнала: 2024, Номер 6
Опубликована: Окт. 11, 2024
Reproductive toxicology testing is essential to safeguard public health of current and future generations. Traditional toxicological male reproduction has focused on evaluating substances for acute toxicity the reproductive system, with fertility assessment as a main endpoint infertility adverse outcome. Newer studies in last few decades have significantly widened our understanding what represents an event toxicology, thus changed perspective constitutes toxicant, such endocrine disrupting chemicals that affect offspring intergenerational manner. Besides or congenital abnormalities, outcomes can present increased likelihood various problems offspring, including metabolic syndrome, neurodevelopmental like autism cancer predisposition, among others. To enable toxicologic accurately represent population, designs need model changing population characteristics exposure circumstances. Current trends increasing importance human include paternal age, associated decline nicotinamide adenine dinucleotide (NAD), higher prevalence obesity, both which are factors study design should account for. In this article, we highlighted some limitations standard protocols, expanding assessed by genetic epigenetic sperm parameters, potential recent developments, mixture testing, novel animal models, vitro systems organoids, multigenerational well silico modelling, machine learning artificial intelligence.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2024, Номер 16(23), С. 4149 - 4149
Опубликована: Ноя. 29, 2024
The aim of this study was to outline the relationships between selected parameters connected with lifestyle and serum anti-Müllerian hormone (AMH) levels, i.e., a marker ovarian reserve. By examining AMH levels in connection nutrient intake body composition parameters, aimed provide preliminary background for further studies focused on establishing dietary recommendations that could lead improvements fertility outcomes.
Язык: Английский
Процитировано
0
Fertility & Reproduction, Год журнала: 2024, Номер 06(04), С. 156 - 165
Опубликована: Дек. 1, 2024
In ancient times, Cambodia was home to one of the largest city complexes on earth, Angkor. At its apogee in 12th century, whole Angkor expanded over >170 hectares and had a population 1–2 million people, which only equaled by that Ancient Rome. subsequently declined but remained occupied until 18th at beginning French protectorate. modern became embedded global conflict against occupying Japanese troops during World War II. This followed lasting war engulfed Southeast Asia area, toll paid limited. second half 20th suddenly site an acute drama, worst world has known since Holocaust. The Khmer Rouge regime led collapse country’s social system triggered brutal rise mortality—direct induced—and gender imbalance. Together with increased mortality, eradicated approximately third population, there profound drop fertility. nearly total after freed 1979 important fertility leading rebound effect or “baby boom” 80s. Today, as 1960 before rates are similar those neighbor, Vietnam. Total rates, neared six children per woman Vietnam 1960, have, however, dropped both countries stand just replacement level.
Язык: Английский
Процитировано
0
Archives of Gerontology and Geriatrics Plus, Год журнала: 2024, Номер unknown, С. 100079 - 100079
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0