Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(4), С. 2074 - 2074

Опубликована: Фев. 19, 2021

Ischemic stroke is one of the most disabling diseases and a leading cause death globally. Despite advances in medical care, global burden continues to grow, as no effective treatments limit or reverse ischemic injury brain are available. However, recent preclinical findings have revealed potential role transient receptor cation 6 (TRPC6) channels endogenous protectors neuronal tissue. Activating TRPC6 various cerebral ischemia models has been found prevent death, whereas blocking enhances sensitivity ischemia. Evidence shown that Ca

Язык: Английский

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Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study

International Journal of Behavioral Nutrition and Physical Activity, Год журнала: 2021, Номер 18(1)

Опубликована: Окт. 19, 2021

Abstract Background The impact of cardiorespiratory fitness (CRF) and other lifestyle-related factors on severe COVID-19 risk is understudied. present study aims to investigate socioeconomic as possible predictors COVID-19, with special focus CRF, further whether these may attenuate obesity- hypertension-related risks, well mediate associations between risk. Methods Out initially 407,131 participants who participated in nationwide occupational health service screening 1992 2020, n = 857 cases (70% men, mean age 49.9 years) were identified. CRF was estimated using a sub-maximum cycle test, lifestyle variables self-reported. Analyses performed including both unmatched, 278,598, sex-and age-matched, 3426, controls. Severe included hospitalization, intensive care or death due COVID-19. Results Patients more had significantly lower higher BMI, greater presence comorbidities often daily smokers. In matched analyses, there graded decrease odds for each ml (OR 0.98, 95% CI 0.970 0.998), two-fold increase the lowest highest (< 32 vs. ≥ 46 ml·min −1 ·kg ) group. Higher BMI (per unit increase, OR 1.09, 1.06 1.12), larger waist circumference cm, 1.04, 1.02 1.06), smoking 0.60, 0.41 0.89) high overall stress 1.36, 1.001 1.84) also remained associated Obesity- blood pressure-related risks attenuated by adjustment variables. Mediation through accounted 9% 54% low education, income blue collar/low skilled occupations results consistent either unmatched Conclusions Both However, obesity pressure, mediated various factors. This emphasises importance interventions maintain general population strengthen resilience especially high-risk individuals.

Язык: Английский

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Physical activity and COVID-19: an observational and Mendelian randomisation study

Journal of Global Health, Год журнала: 2020, Номер 10(2)

Опубликована: Дек. 1, 2020

Physical activity (PA) is known to be a protective lifestyle factor against several non-communicable diseases while its impact on infectious diseases, including Coronavirus Disease 2019 (COVID-19) not as clear.

Язык: Английский

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The Impact of Reduced Training Activity of Elite Kickboxers on Physical Fitness, Body Build, and Performance during Competitions

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(8), С. 4342 - 4342

Опубликована: Апрель 20, 2021

Background: Kickboxing is a combat sport where athletes require constant supervision of coach. The outbreak the pandemic caused by SARS-CoV-2 has led to crisis in many sectors, including sport. Global efforts limit spread pathogen resulted temporary lockdowns that limited sporting activity, thus deteriorating athletes’ physical fitness. Methods: participants included 20 kickboxers competing at international level. Their fitness was evaluated based on test developed International Committee Standardization Physical Fitness Test (ICSPFT) and their body build assessed using Tanita BC601 composition monitor height meter. Differences between before COVID-19 during after re-opening sports facilities were evaluated. Results: Temporary closing clubs increase mass 2.65 kg average significantly deteriorated Conclusions: restrictions activity aimed containing significant reduction increased participants. This likely cause worse performance nearest competitions have negative impact health status immunity diseases.

Язык: Английский

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Adverse effects of COVID-19 related lockdown on pain, physical activity and psychological wellbeing in people with chronic pain

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Июнь 5, 2020

Abstract Countries across the world imposed lockdown restrictions during COVID-19 pandemic. It has been proposed that conditions disproportionately impact those living with chronic pain, requiring adaptation to treatment and care strategies. We investigated how in United Kingdom impacted individuals pain (N = 431) relative a healthy control group 88) using an online survey. In accordance fear-avoidance model, we hypothesised increases perceived psychological distress would be mediated by catastrophizing. Survey questions answered period, probing patients’ self-perceived changes retrospectively, revealed people their severity compared before lockdown. They were also more adversely affected pain-free individuals, demonstrating greater anxiety depressed mood, increased loneliness reduced levels of physical exercise. Pain catastrophizing was found important factor predicting extent accounted for relationship between decreased mood pain. Perceived decreases exercise independently predicted perceptions Interestingly, actual symptoms (measured at two time points pre- post-lockdown subgroup, N 85) did not change significantly on average, but reporting demonstrated baseline Overall, findings suggest remote management provision target reduction activity could beneficial patients overcoming adverse effects

Язык: Английский

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