Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Май 29, 2023
Bone
marrow
stromal
cell
antigen-1
(BST-1/CD157)
is
an
immune/inflammatory
regulator
that
functions
as
both
nicotinamide
adenine
dinucleotide-metabolizing
ectoenzyme
and
cell-surface
signaling
receptor.
BST-1/CD157
expressed
not
only
in
peripheral
tissues,
but
the
central
nervous
system
(CNS).
Although
its
pathophysiological
significance
CNS
still
unclear,
clinical
genetic
studies
over
a
decade
have
begun
revealing
relationships
between
neuropsychiatric
diseases
including
Parkinson’s
disease,
autism
spectrum
disorders,
sleep
depressive
disorders
restless
leg
syndrome.
This
review
summarizes
accumulating
evidence
for
involvement
of
these
disorders.
Язык: Английский
Targeting inhibition of prognosis-related nicotinamide metabolism genes, including poly (ADP-ribose) polymerase 9 (PARP-9) attenuates glioma progression
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 19, 2024
Abstract
Background
Nicotinamide
(NAM)
metabolism
plays
a
significant
role
in
glioma
development.
This
study
aimed
to
investigate
the
correlation
between
NAM
metabolic
genes
and
prognosis,
immune
microenvironment,
tumor
progression
glioma.
Methods
We
analyzed
expression
prognostic
significance
of
NAM-metabolism-related
patients
with
develop
new
metabolism-related
signature
(NMRS)
nomograms
using
data
from
The
Cancer
Genome
Atlas
(TCGA)
Gene
Expression
Omnibus
(GEO)
databases
compared
differences
gene
set
enrichment
analysis
(GSEA),
protein-protein
interaction
networks,
competing
endogenous
RNA
(ceRNA)
regulatory
network,
mutation
load,
landscape
different
groups.
Additionally,
we
employed
Western
blotting,
cell
proliferation
apoptosis
analysis,
Semi-quantitative
Reverse
Transcription-Polymerase
Chain
Reaction(SqRT-PCR),
xenograft
model
nude
mice
PARP9
progression.
Results
Our
identified
eight
genes,
including
NT5C1A,
NNMT,
CDKN1A,
PTGS2,
PNP,
PARP10,
PARP14,
PARP9,
that
exhibited
prognosis
could
act
as
an
independent
indicator.
Risk
stratification
was
conducted
based
on
NMRS,
low-risk
group
more
favorable
clinical
results.
GSEA
revealed
immune-associated
pathways,
while
high-risk
showed
cancer-related
pathways.
ESTIMATE
single-sample
algorithms
indicated
displayed
higher
antitumor
immunocyte
infiltration.
TIDE
responded
favorably
immunotherapy.
Furthermore,
validation
experiments
is
proto-oncogene
associated
PARP9-JAK2-STAT3
signaling
pathway.
Conclusion
developed
NMRS
for
predicting
treatment
efficacy
gene,
potential
therapeutic
target
Язык: Английский
Employ machine learning to identify NAD+ metabolism-related diagnostic markers for ischemic stroke and develop a diagnostic model
Experimental Gerontology,
Год журнала:
2024,
Номер
196, С. 112584 - 112584
Опубликована: Сен. 19, 2024
Язык: Английский