Environmental Sciences Europe,
Год журнала:
2024,
Номер
36(1)
Опубликована: Фев. 6, 2024
Abstract
Glyphosate
(GLY),
the
most
widely
used
herbicide
active
ingredient
(AI)
in
world,
is
frequently
detected
aquatic
environments
where
it
can
affect
non-target
organisms.
Globally,
more
than
2000
commercial
GLY-based
herbicides
(GBHs)
are
to
control
weeds.
Non-target
organisms
exposed
complex
pesticide
formulations
under
real
environmental
conditions,
but
co-formulants
contained
GBHs
classified
as
so-called
inert
and
inactive
ingredients
terms
of
their
biological
effects.
The
main
objective
this
comprehensive
review
compile
results
ecotoxicological
studies
on
side-effects
GLY,
GBHs,
formulating
agents.
Based
demonstrated
for
a
variety
plant
animal
organisms,
oxidative
stress
appears
be
major
trigger
these
adverse
effects,
affecting
integrity
DNA
other
biochemical
functions.
Furthermore,
there
evidence
impairment
various
physiological
behavioral
Adverse
effects
GLY
have
been
observed
even
at
very
low
concentrations.
There
also
differences
sensitivity
tested,
with
similar
lifestyles,
habitats
or
identical
taxa.
typically
investigate
short-term
single
exposure
GLY/GBH
species,
whilst
reality
multiple
applications
together
pesticides
common
during
cropping
cycle.
Moreover,
interactions
between
GLY/GBHs
contaminants
rarely
studied.
Higher
toxicity
compared
alone
has
often
observed,
demonstrating
that
highly
toxic
own
markedly
increase
GBH
formulation.
possible
impurities
such
heavy
metals,
cause
additional
problems
environment
food
safety.
widespread
massive
use
leads
increased
hazards.
In
addition,
need
revision
risk
assessment
system
emphasized.
According
studies,
current
pollution
by
problematic
cannot
considered
environmentally
sustainable.
It
is,
therefore,
necessary
least
tighten
permitted
forms
use.
Water,
Год журнала:
2025,
Номер
17(2), С. 191 - 191
Опубликована: Янв. 12, 2025
Dimethyl
sulfoxide
(DMSO)
is
an
aprotic
solvent
widely
used
in
ecotoxicological
assays,
suitable
for
solubilizing
a
wide
range
of
polar
and
non-polar
substances.
The
aim
this
study
was
to
analyze
the
species-specific
biological
response
model
organisms
Daphnia
magna
Ceriodaphnia
dubia
0.5%
DMSO,
under
feeding
conditions.
Both
species
were
exposed
culture
medium,
with
or
without
unicellular
algae
(Raphidocelis
subcapitata,
Tetradesmus
obliquus),
either
individually
combination;
pretreated
not
DMSO.
exposure
carried
out
acute
(24
h
48
h)
chronic
(72
168
ecotoxicity
tests.
experimental
results
suggest
that
lower
DMSO
concentration
limit
(<0.5%)
would
be
appropriate
C.
due
its
greater
sensitivity
solvent.
Finally,
considering
ingestion
DMSO-contaminated
algae,
it
can
concluded
that,
certain
conditions,
ingested
through
diet
may
significantly
affect
mortality
both
D.
dubia.
Journal of Thermal Analysis and Calorimetry,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 8, 2024
Abstract
Due
to
the
serious
environmental
impacts
of
plastic
pollution,
some
conventional
plastics
have
been
replaced
with
biodegradable
alternatives.
However,
these
options
can
also
fragment
and
form
microplastics,
which
be
ingested
by
harm
various
biota.
The
standard
methods
for
quantifying
microplastics
involve
digestion
gut
or
whole
organism
using
acidic,
alkaline,
oxidative
processes.
aggressive
may
destroy
leading
erroneous
results.
Therefore,
in
this
study,
we
employed
thermal
analysis
methods,
specifically
differential
scanning
calorimetry
(DSC)
thermogravimetry
(TG),
quantify
ingestion
poly-3-hydroxybutyrate
(P3HB),
a
microplastic,
freshwater
crustacean,
Daphnia
magna
.
During
chronic
experiments,
analysed
organisms
exposed
P3HB
sizes
smaller
than
125
63
μm,
at
concentrations
ranging
from
1.56–25
mg
L
−1
DSC
identified
an
endothermic
peak
associated
melting
semicrystalline
P3HB,
its
enthalpies
were
utilised
compute
number/mass
D.
Notably,
shifts
points
suggested
that
higher
induced
particle
agglomeration,
agglomerates
could
not
penetrate
deeply
into
organism.
TG
approach
involved
subtracting
mass
loss
between
200
400
°C
specimens
suspensions
controls
without
exposure.
Both
provided
comparable
data,
revealing
that,
depending
on
size,
individual
up
10%
their
body
mass.
Our
findings
indicate
both
effectively
detect
(and
potentially
other
fragments),
demonstrating
better
sensitivity.
While
did
enable
us
calculate
level
determination
quantification,
able
demonstrate
only
one
specimen
lowest
suspension
concentration.
This
indicates
μm
fraction
approximately
3
μg
whereas
those
around
4
P3HB.
introduced
expand
possibilities
detecting
probably
nanoplastics,
zooplankton
possibly
species.
Clinical Cancer Bulletin,
Год журнала:
2024,
Номер
3(1)
Опубликована: Март 25, 2024
Abstract
The
liver,
the
largest
solid
organ
in
body,
is
susceptible
to
metabolic
diseases
and
malignant
tumors.
Studying
its
physiological
pathological
processes
helps
optimize
clinical
treatment.
Organoids
are
a
novel
tool
for
studying
physical
development,
disease
mechanisms,
high-throughput
drug
screening
due
their
similarity
composition,
structure,
function
internal
organs.
Recent
studies
have
shown
that
stem
cells,
hepatocytes,
or
cholangiocytes
can
form
“liver
organoids”
under
synergistic
action
of
specific
extracellular
matrix
various
signaling
molecules.
This
review
outlines
techniques
generating
liver
organoids
maximally
recapitulate
structure
functions
vitro
thoroughly
discusses
customary
applications
derived
from
tissue,
induced
pluripotent
cells
(iPSCs)
In
this
review,
meticulous
analysis
provided
comparatively
advanced
culture
systems
used
construction
cancer-derived
organoids.
Additionally,
we
reviewed
progress
modeling,
efficacy,
toxicity
evaluation,
hopes
innovative
ideas
research
Frontiers in Marine Science,
Год журнала:
2024,
Номер
11
Опубликована: Фев. 5, 2024
Polystyrene
is
widely
used
in
disposable
products
and
now
a
ubiquitous
plastic
pollutant
aquatic
environments,
where
it
degrades
into
smaller
particles
that
leach
potentially
toxic
chemicals.
However,
knowledge
regarding
the
impacts
of
leachates
remains
limited.
This
study
investigates
lethal
nonlethal
effects
polystyrene
leachate
on
two
ecologically
significant
organisms,
Daphnia
magna
(water
flea)
Artemia
salina
(brine
shrimp).
were
prepared
seawater,
freshwater,
sterile,
pure
water
by
incubating
material
each
media
under
natural
conditions
for
six
months.
D.
A.
exposed
to
varying
concentrations
controlled
laboratory
conditions,
monitoring
their
survival,
as
well
measuring
reactive
oxygen
species
antioxidant
responses
superoxide
dismutase
catalase
activity.
The
data
show
was
more
significantly
affected
with
higher
mortality
observed
at
lower
concentrations,
linked
seawater
enhancing
leaching
additives.
Moreover,
non-lethal
antioxidative
maintained
homeostasis
both
organisms.
Considering
current
reported
microplastic
aquatics
adequate
response,
from
does
not
pose
severe
threat
these
Nevertheless,
hydrological
characteristics
waterbodies
may
cause
hotspots,
which
could
concentrate
plastics
thus
leachates,
necessitating
action
reduce
pollution
level
avoid
future
surges.
highlights
ecological
significance
pollution,
emphasizing
need
comprehensive
regulatory
measures
development
sustainable
alternatives
polystyrene-based
products.
distinct
imply
impact
varies
among
species,
further
research
elucidate
broader
consequences.
Understanding
how
affects
keystone
provides
crucial
insights
overall
implications
ecosystems.
Freshwater Biology,
Год журнала:
2024,
Номер
69(4), С. 461 - 476
Опубликована: Фев. 11, 2024
Abstract
Micro/nanoplastics
pose
a
new
environmental
threat
to
aquatic
ecosystems.
The
model
organism
Daphnia
spp.
has
been
used
in
many
exposure
studies
investigate
the
effect
of
micro/nanoplastics
on
fitness.
However,
owing
variation
experimental
approaches,
it
is
difficult
compare
findings.
aim
our
study
was
systematically
review
research
fitness,
identify
gaps
and
offer
recommendations
for
future
studies.
We
synthesised
121
extracted
data
numerous
categories
concerning
design,
micro/nanoplastic
characteristics
ecotoxicological
endpoints.
32
were
included
meta‐analysis
reproduction.
Existing
exhibits
several
limitations.
majority
experiments
have
conducted
exclusively
using
magna
,
neglecting
other
species
leading
an
inherent
bias
representation
broader
genus.
Then,
these
predominantly
single
genotype
disregarding
potential
clonal
variation.
In
addition,
most
investigated
only
generation,
although
limited
number
multigenerational
available
suggest
increasing
toxicity
trend
with
subsequent
generations,
even
if
there
no
impact
F
0
generation.
Regarding
types
plastics
tested,
focused
pristine,
spherical
microplastic
particles,
primarily
composed
polystyrene,
particle
sizes
<100
μm,
at
concentrations
>0.1
mg/L.
This
narrow
focus
limits
applicability
findings
environmentally
relevant
scenarios,
where
can
take
various
shapes
composition,
undergo
aging
usually
occur
lower
than
those
reviewed.
primary
response
variable
assessed
mortality,
followed
by
variations
reproductive
traits
or
body
size.
focusing
unveiled
consistent
adverse
influence
production
offspring
.
Future
should
test
micro/nanoplastics,
smaller,
lake‐inhabiting
species,
incorporate
extend
scope
include
multiple
generations.
Moreover,
recognising
complexity
real‐world
we
recommend
integrating
assessments
effects
stressors.
By
simulating
such
conditions,
yield
insights
that
better
mirror
complexities
ecological
systems
provide
more
accurate
consequences
pollution.
