Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets DOI Creative Commons

Ravneet K. Hansi,

Maral Ranjbar,

Christiane E. Whetstone

и другие.

Biomedicines, Год журнала: 2024, Номер 12(10), С. 2312 - 2312

Опубликована: Окт. 11, 2024

Asthma is a chronic respiratory condition predominantly driven by type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th2 cells group innate lymphoid (ILC2s), along with other effector cells. While these are produced in response to inhaled triggers, allergens, pathogens or particulate matter, disproportionate alarmin production airway epithelial can lead asthma exacerbations. With upstream inflammatory cascade, understanding pathways which regulated expressed critical further explore new therapeutics for treatment asthmatic patients. This review emphasizes role epithelium epithelial-derived pathogenesis highlights potential targeting promising therapeutic improve outcomes

Язык: Английский

Analysis of cytotoxicity and genotoxicity of diesel exhaust PM2.5 generated from diesel and dual natural gas-diesel engines DOI
Juan Sebastian Pino, Pedro N. Alvarado, Á. Larrea

и другие.

Environmental Toxicology and Pharmacology, Год журнала: 2025, Номер 114, С. 104638 - 104638

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0
Regulation of calcium signaling prevents neuronal death mediated by NIST DEP in xenoferroptotic cell death conditions DOI Creative Commons

L M Zhang,

Hong Yan,

Mohammad Saidur Rahman

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137374 - 137374

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
The enigma of mitochondrial epigenetic alterations in air pollution-induced neurodegenerative diseases DOI

Sayanti Acharyya,

Sruthy Hari Kumar,

Apoorva Chouksey

и другие.

NeuroToxicology, Год журнала: 2024, Номер 105, С. 158 - 183

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

2
Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets DOI Creative Commons

Ravneet K. Hansi,

Maral Ranjbar,

Christiane E. Whetstone

и другие.

Biomedicines, Год журнала: 2024, Номер 12(10), С. 2312 - 2312

Опубликована: Окт. 11, 2024

Asthma is a chronic respiratory condition predominantly driven by type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th2 cells group innate lymphoid (ILC2s), along with other effector cells. While these are produced in response to inhaled triggers, allergens, pathogens or particulate matter, disproportionate alarmin production airway epithelial can lead asthma exacerbations. With upstream inflammatory cascade, understanding pathways which regulated expressed critical further explore new therapeutics for treatment asthmatic patients. This review emphasizes role epithelium epithelial-derived pathogenesis highlights potential targeting promising therapeutic improve outcomes

Язык: Английский

Процитировано

2