Cannabis: a multifaceted plant with endless potentials

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 15, 2023

Cannabis sativa , also known as “hemp” or “weed,” is a versatile plant with various uses in medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available literature on ecology, chemical composition, phytochemistry, pharmacology, traditional uses, industrial toxicology of . So far, 566 compounds have been isolated from including 125 cannabinoids 198 non-cannabinoids. The psychoactive physiologically active part cannabinoid, mostly found flowers, but present smaller amounts leaves, stems, seeds. Of all phytochemicals, terpenes form largest composition plant. Pharmacological evidence reveals that plants contain which exhibit potential antioxidants, antibacterial agents, anticancer anti-inflammatory agents. Furthermore, reported applications food cosmetic industries. Significantly, cultivation has minimal negative impact environment terms cultivation. Most studies focused make-up, pharmacological effects, not much about toxic effects. Overall, enormous for biological well other medicinal uses. However, further research necessary fully understand explore beneficial properties

Язык: Английский

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Synthesis and Characterization of the Diastereomers of HHC and H4CBD

Natural Product Communications, Год журнала: 2023, Номер 18(3)

Опубликована: Март 1, 2023

The characterization of any compound is important in the field chemistry. As cannabinoid chemistry grows so does need for new cannabinoids or rare that gain popularity within consumer and research fields. Hexahydrocannabinol (HHC) a hydrogenated analogue Δ9-tetrahydrocannabinol (THC), also found trace amounts naturally Cannabis sativa plant, has been gaining attention cannabis industry. Hexahydrocannabidiol (H4CBD) synthetic to cannabidiol (CBD). Identifying diastereomers with instrumentation plays huge role adding valuable information structure parameters others identify such cannabinoids. Elucidation HHC H4CBD were performed using current analytical techniques as 1D 2D nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), effectively characterizing both H4CBD.

Язык: Английский

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Therapeutic targeting of the tumor microenvironments with cannabinoids and their analogs: Update on clinical trials

Environmental Research, Год журнала: 2023, Номер 231, С. 115862 - 115862

Опубликована: Май 4, 2023

Язык: Английский

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Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 18, 2024

Abstract Human pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and lethal tumor of the exocrine pancreas. Cannabinoids extracted from hemp plant Cannabis sativa have been suggested as potential therapeutic agent in several human tumors. However, anti–tumor effect cannabinoids on PDAC not entirely clarified. In this study, anti–proliferative apoptotic cannabinoid solution (THC:CBD at 1:6) dose 1, 5, 10 mg/kg body weight compared to negative control (sesame oil) positive (5-fluorouracil) was investigated xenograft nude mice model. The findings showed that significantly decreased mitotic cells mitotic/apoptotic ratio, meanwhile dramatically increased cells. Parallelly, downregulated Ki-67 PCNA expression levels. Interestingly, upregulated BAX, BAX/BCL-2 Caspase-3, meanwhile, BCL-2 level could change Caspase-8 level. These suggest inhibit proliferation induce apoptosis models. Cannabinoids, including THC:CBD, should be further studied for use potent PDCA humans.

Язык: Английский

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Talaromides A–C, Bioactive Cyclic Heptapeptides from Talaromyces siglerae Isolated from a Marine Sponge

Journal of Natural Products, Год журнала: 2024, Номер 87(4), С. 1230 - 1234

Опубликована: Апрель 16, 2024

Three new cyclic heptapeptides, talaromides A–C (1–3), were isolated from cultures produced by the fungus Talaromyces siglerae (Ascomycota), an unidentified sponge. The structures, featuring unusual proline-anthranilic moiety, elucidated analysis of spectroscopic data and chemical transformations, including advanced Marfey's method GITC derivatization. Talaromides A B inhibited migration activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.

Язык: Английский

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Bioactive Piperazic Acid-Bearing Cyclodepsipeptides, Lydiamycins E–H, from an Endophytic Streptomyces sp. Associated with Cinnamomum cassia

Journal of Natural Products, Год журнала: 2023, Номер 86(4), С. 751 - 758

Опубликована: Фев. 22, 2023

A chemical investigation of the endophytic Streptomyces sp. HBQ95, associated with medicinal plant Cinnamomum cassia Presl, enabled discovery four new piperazic acid-bearing cyclodepsipeptides, lydiamycins E–H (1–4), and one known compound (lydiamycin A). Their structures, including absolute configurations, were defined by a combination spectroscopic analyses multiple manipulations. Lydiamycins F–H (2–4) (5) exhibited antimetastatic activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.

Язык: Английский

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Cannabis and Cannabinoids in Multiple Sclerosis: From Experimental Models to Clinical Practice—A Review

American Journal of Therapeutics, Год журнала: 2022, Номер 30(3), С. e220 - e231

Опубликована: Сен. 30, 2022

Background: As far as 80% of people diagnosed with multiple sclerosis (MS) experience disabling symptoms in the course disease, such spasticity and neuropathic pain. first-line symptomatic therapy is associated important adverse reactions, cannabinoids have become increasingly popular among patients MS. This review intends to provide an overview evidence role treating related MS encourage further research on this matter. Areas Uncertainty: To date, supporting cannabis its derivatives alleviating MS-related comes only from studies experimental models demyelination. best our knowledge, relatively few clinical trials inquired about therapeutic effects MS, variable results. Data Sources: We conducted a literature search through PubMed Google Scholar beginning until 2022. included articles English describing latest findings regarding endocannabinoid system, pharmacology cannabinoids, their purpose Results: Evidence preclinical showed that can limit demyelination process, promote remyelination, anti-inflammatory properties by reducing immune cell infiltration central nervous system mice autoimmune encephalomyelitis. Moreover, it has been established encephalomyelitis treated experienced significant reduction slowing disease progression. Given complexity human systems, did not anticipated subjects. However, data obtained some beneficial results single or add-on pain Conclusion: Considering various mechanisms action good tolerability, remain interesting for chronic

Язык: Английский

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Nanoliposomes for Controlled Release of Cannabinodiol at Relevant Gastrointestinal Conditions

ACS Omega, Год журнала: 2023, Номер 8(46), С. 43698 - 43707

Опубликована: Ноя. 9, 2023

Cannabidiol (CBD) has significant therapeutic potential; nevertheless, its advance as an effective drug by the pharmaceutical business is hindered inherent characteristics, such low bioavailability, water solubility, and variable pharmacokinetic profiles. This research aimed to develop nanoliposomes using easy low-cost method improve hydrosolubility of CBD achieve a controlled delivery active principle under relevant physiological conditions from mouth intestine; cytotoxic antitumor activities were also evaluated. To objective, core-shell based on synthesized in three steps characterized terms shape, size, surface chemistry, thermal capacity, charge density through transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), potential (PZ), respectively. CBD-controlled trials carried out simulated mouth-duodenal fitted Korsmeyer-Peppas Noyes-Whitney models conclude about pharmacokinetics nano-CBD. Cytotoxicity studies nonmalignant human keratinocytes (HaCaT) evaluate safety recommended consumption dose, finally, antiproliferative capacity nano-CBD colon carcinoma cells (SW480) was determined beginning proposal for cancer treatment. The characterization results verified solubility nanoencapsulated, structure, size nanometric regime, presence synthesis components. dissolution rate at duodenal higher than that buccal stomach environments, respectively, this behavior associated with shell (lecithin) chemical which destabilizes pH above 7.2, allowing release non-Fickian diffusion corroborated model. In vitro biological tests revealed innocuousness cyto-security up 1000 mg·L-1 when evaluated HaCaT concentrations showed activity against taking first step chemotherapeutic proposal. These are unprecedented propose selective system cost provides new form administration chemo

Язык: Английский

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Cannabidiol exhibits potent anti-cancer activity against gemcitabine-resistant cholangiocarcinoma via ER-stress induction in vitro and in vivo

BMC Complementary Medicine and Therapies, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 30, 2024

Язык: Английский

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Antineoplastic Properties of THCV, HHC and their anti-Proliferative effects on HPAF-II, MIA-paca2, Aspc-1, and PANC-1 PDAC Pancreatic Cell Lines

Опубликована: Дек. 21, 2022

Cannabinoid receptors CB1 and CB2 are the primary endogenous with which cannabinoids interact, inducing physiological psychological effects. Although interactions other including TRPV1 GPCR55, have been recognized in earlier studies, these may play a significant role cancer remediation through unspecified upregulation or downregulation of specific pathways. The main active constituents within cannabis plant cannabidiol (CBD) tetrahydrocannabinol (THC), categorized as either non-intoxicating benefit intoxicating no benefit. These categories constantly ignored, shown efficacy treatment certain diseases ailments single-agent compounds. Tetrahydrocannabivarin (THCV), rare cannabinoid, is homologue THC, C5 alkyl chain having three carbons rather than standard five carbon length. THCV has garnered attention clinical setting an anti-obesity drug treating glucose issues. Hexahydrocannabinol (HHC), hydrogenated analogue cannabinoid like THCV. cyclic considered rare, because they typically found minimal to trace amounts sativa their given C. indica, ruderalis sub species. Increased popularity led proposed experimentation leading assessing cytotoxicity toward, cells pancreas (MIA-PaCa2, HPAF-II, PANC1). data evaluated such studies idea towards pancreatic due modest single agent antineoplastics compared common on market, evidence being strongly presented when commercially available anticancer agents poly(ADP-ribose) polymerase (PARP) inhibitors.

Язык: Английский

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