International Journal of Advanced Scientific Research and Innovation,
Год журнала:
2022,
Номер
5(1), С. 80 - 117
Опубликована: Июнь 1, 2022
One
of
the
biggest
concerns
in
our
food
supply
is
heavy
metal
pollution,
which
poses
a
major
threat
to
ecology.Because
its
numerous
industrial
applications,
cadmium
(Cd)
significant
that
widely
dispersed
environment
and
recognized
as
worldwide
source
illness
adversely
affects
various
body
systems
humans
animals.Adequate
new
chelating
drugs
conjunction
with
chemical
cleaning
supportive
treatment
are
necessary
for
patients
suffering
from
poisoning.Therefore,
this
study
was
carried
out
investigate
protective
effects
propolis
on
CdCl
2
-induced
toxicity
male
Japanese
quails.One
hundred,
twenty-day-old,
100±5
gm
weight,
quails
were
randomly
divided
into
four
equal
groups:
control
(basal
feed
ad
libitum
no
additives),
propolis-treated
group
(300
mg/L
water),
-exposed
(5
mg/kg
feed),
propolis+CdCl
-treated
groups
(same
previous
doses).The
exposed
40
days
under
16/8-hour
light/dark
cycle.The
results
declared
lowered
activities
antioxidant
system,
disturbed
hepatic,
renal
biomarkers,
induced
vast
array
notable
multiorgan
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
279, С. 116498 - 116498
Опубликована: Май 27, 2024
Copper
(Cu)
contamination
represents
a
persistent
and
significant
form
of
heavy
metal
pollution
in
agricultural
ecosystems,
posing
serious
threats
to
organisms
current
society.
Spiders
serve
as
crucial
biological
indicators
for
assessing
the
impact
metals-induced
toxicity.
However,
specific
molecular
responses
spiders
Cu
exposure
mechanisms
involved
are
not
well
understood.
In
our
study,
wolf
pond
spiders,
Pirata
subpiraticus,
were
exposed
21
d,
resulting
notable
decline
survival
rates
compared
with
control
(n
=
50,
p
<
0.05).
We
observed
an
increased
expression
enzymes
like
glutathione
peroxidase
superoxide
dismutase
(p
0.05),
signaling
strong
oxidative
stress
response
counteracting
harmful
effects
reactive
oxygen
species.
This
was
corroborated
by
rise
malondialdehyde
levels
marker
lipid
peroxidation
damage.
Transcriptomic
metabolomic
analyses
revealed
2004
differentially
expressed
genes
(DEGs)
220
metabolites
(DEMs).
A
number
these
DEGs
biosynthetic
process
antioxidant
activity.
conjoint
analysis
that
under
stress,
several
important
altered
(e.g.,
cathepsin
A,
legumain,
lysosomal
acid
lipase),
affecting
activities
key
processes
components,
such
lysosome
insect
hormone
biosynthesis.
Additionally,
protein
interaction
network
showed
up-regulation
apoptotic
process,
glutamate
synthase
activity,
peroxisome,
suggesting
activate
cellular
protective
strategies
cope
maintain
homeostasis.
study
only
deepens
understanding
spider
biology
context
environmental
but
also
makes
contribution
field
biology.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 12, 2024
Cadmium
(Cd)
is
a
highly
hazardous
toxic
substance
that
can
cause
serious
harm
to
animals.
Previous
studies
have
indicated
cadmium
chloride
(CdCl
2
)
damage
organs,
such
as
the
liver,
ovaries,
and
testicles.
Naringenin
(Nar)
represents
flavonoid
with
various
properties
promote
alleviation
of
Cd-induced
damage.
In
this
experiment,
60
chickens
were
divided
into
control
group,
150
mg/kg
CdCl
treatment
250
Nar
+
co-treatment
which
treated
for
8
weeks.
Kidney
tissues
samples
collected
investigate
kidney
function,
including
oxidative
stress
(OS),
endoplasmic
reticulum
(ER)
stress,
autophagy
activity.
Experimental
results
showed
decreased
weight
increased
relative
their
kidneys
after
treatment.
The
increase
in
NAG,
BUN,
Cr,
UA
activities,
well
MDA
GSH
contents,
decrease
activities
T-AOC,
SOD,
CAT
kidney,
manifested
renal
injury
by
OS
chickens.
TUNEL
staining
revealed
induced
apoptosis
cells.
upregulates
mRNA
protein
expression
levels
GRP78,
PERK,
eIF2α,
ATF4,
ATF6,
CHOP,
LC3,
inhibited
P62
proteins,
leads
ER
autophagy.
group
exhibited
alleviated
-induced
injury,
OS,
Research
has
demonstrated
reduces
through
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10662 - 10662
Опубликована: Окт. 3, 2024
Agricultural
areas
can
provide
sources
of
food
and
hiding
nesting
places
for
wild
birds.
Thus,
the
chemical
load
potentially
toxic
elements
(Cd,
Cu,
Pb)
due
to
industrial
agricultural
activities
affect
not
only
adult
birds
but
also
embryos
developing
in
egg.
The
effects
heavy
metals
applied
alone
were
investigated
on
chicken
early
late
stages
embryonic
development
using
injection
immersion
treatment
methods.
On
day
3
incubation,
permanent
preparations
made
from
study
stage.
There
no
significant
differences
observed
embryo
deaths
developmental
abnormalities
this
19
number
deaths,
body
weight
embryos,
type
examined.
mortality
was
statistically
higher
groups
treated
with
cadmium
lead
case
treatment.
A
increase
disorders
copper-treated
group
application.
significantly
decreased
cadmium-
lead-treated
both
However,
a
change
realized
method.
