Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

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Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Alzheimer's disease (AD), the most prevalent neurodegenerative disorder among older adults, significantly impairs behavioral and cognitive functions, posing a severe threat to patients' health quality of life. The Tricetin (TRN), natural flavonoid found in wheat, pomegranate, eucalyptus honey, has demonstrated anti-inflammatory, antitumor, neuroprotective properties. However, its role context AD not been previously explored. This study investigated antineuroinflammatory autophagic protective effects TRN lipopolysaccharide (LPS)-induced BV2 cells D-galactose/sodium nitrite/aluminum chloride (D-gal/NaNO2/AlCl3)-induced mice. RNA sequencing examined underlying mechanisms by which ameliorates AD-related pathologies. Our research findings revealed that improved memory mobility mice, reduced Aβ deposition, inhibited Tau protein phosphorylation. Furthermore, regulated enzyme activities pathological markers associated with AD. Moreover, it modulated inflammatory mediators, nuclear translocation NF-κB LPS-induced cells, exerted anti-inflammatory via PI3K/Akt/mTOR signaling pathway. In conclusion, robust vitro vivo models regulating These highlight potential as promising therapeutic agent for treating

Язык: Английский

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Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3/NRF2/HO-1 activation

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110461 - 110461

Опубликована: Апрель 1, 2025

Язык: Английский

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Mechanistic insights into acetamiprid-induced genotoxicity on the myocardium and potential ameliorative role of resveratrol

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 110, С. 104526 - 104526

Опубликована: Авг. 5, 2024

Язык: Английский

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