Insect-specific virus platforms for arbovirus vaccine development

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 14, 2025

Certain insect-specific viruses (ISVs), specifically the mosquito alphaviruses, Eilat and Yada viruses, orthoflaviviruses, Binjari, Aripo, YN15-283-02 Chaoyang have emerged as potential platforms for generation of whole virus vaccines human veterinary applications. These ISVs are remarkably tolerant substitution their structural polyproteins with those alphaviruses orthoflaviviruses that pathogenic in humans and/or animals. The resulting ISV-based chimeric been evaluated mouse models demonstrated safety efficacy non-human primates, crocodiles pigs. Targets include chikungunya, Venezuelan eastern equine encephalitis, dengue, Zika, yellow fever, Japanese encephalitis West Nile viruses. provide authentically folded tertiary quaternary virion particle structures to immune system, a key feature induction protective antibody responses. manufactured C6/36 or C7-10 cell lines, where they grow high titers, but do not replicate vertebrate vaccine recipients. This review discusses progress these emerging technologies addresses challenges related adjuvanting, safety, manufacturing.

Язык: Английский

Virus-like particles: Innovative strategies for combatting emerging and re-emerging viral threats

The Microbe, Год журнала: 2025, Номер unknown, С. 100351 - 100351

Опубликована: Апрель 1, 2025

Язык: Английский