International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11645 - 11645
Опубликована: Окт. 30, 2024
Microplastic
is
an
environmental
hazard
to
which
both
animals
and
humans
are
exposed.
Current
reports
show
that
it
can
cause
inflammation,
including
in
the
gastrointestinal
tract.
To
examine
impact
on
ileum,
15
eight-week-old
gilts
(five
individuals/group)
were
exposed
PET
microplastics
(7.6
µm-416.9
µm)
at
a
dose
of
0.1
g/day
or
1
for
28
days.
The
collected
ileum
fragments
investigated
cytokine
concentrations
(IL-1β,
IL-6,
IL-8,
IL-10,
TNF-α;
ELISA
test),
neuron
populations
(cocaine
amphetamine-regulated
transcript,
galanin,
neuronal
nitric
oxide
synthase,
substance
P,
vesicular
acetylcholine
transporter,
vasoactive
intestinal
peptide;
immunofluorescence
staining),
morphometric
parameters
(histological
analysis).
Under
influence
MP-PET,
there
was
reduction
CART-
GAL-positive
neurons
submucosal
plexuses
nNOS-,
VAChT-,
VIP-positive
all
plexuses.
In
contrast,
increase
myenteric
plexus
SP-positive
IL-1β,
TNF-α
did
not
undergo
statistically
significant
changes
under
low
high
MP-PET.
histological
structure
exclusively
concerned
thinning
mucosa
muscularis
externa.
results
support
thesis
MP-PET
neutral
ileal
cells.
Advances in environmental engineering and green technologies book series,
Год журнала:
2024,
Номер
unknown, С. 205 - 224
Опубликована: Сен. 25, 2024
Plastic
pollution,
particularly
in
the
form
of
microplastics
and
nanoplastics,
has
emerged
as
a
significant
environmental
concern
with
far-reaching
implications.
This
chapter
delves
into
origins,
characteristics,
effects,
identification
methods
removal
these
micro/nano
plastic
particles
that
are
prevailing
our
ecosystems.
The
properties
plastics
make
them
versatile
widely
used
materials
commercial
world,
but
this
led
to
their
extensive
production
disposal,
contributing
formation
accumulation
more
nanoplastics
various
natural
habitats.
These
smaller
fragments,
categorized
primary
secondary
plastic,
pose
greater
threat
environment
due
ability
carry
harmful
substances
disrupt
Collaborative
efforts
among
researchers,
policymakers,
industries
essential
developing
effective
strategies
for
detecting,
mitigating,
preventing
further
pollution.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11645 - 11645
Опубликована: Окт. 30, 2024
Microplastic
is
an
environmental
hazard
to
which
both
animals
and
humans
are
exposed.
Current
reports
show
that
it
can
cause
inflammation,
including
in
the
gastrointestinal
tract.
To
examine
impact
on
ileum,
15
eight-week-old
gilts
(five
individuals/group)
were
exposed
PET
microplastics
(7.6
µm-416.9
µm)
at
a
dose
of
0.1
g/day
or
1
for
28
days.
The
collected
ileum
fragments
investigated
cytokine
concentrations
(IL-1β,
IL-6,
IL-8,
IL-10,
TNF-α;
ELISA
test),
neuron
populations
(cocaine
amphetamine-regulated
transcript,
galanin,
neuronal
nitric
oxide
synthase,
substance
P,
vesicular
acetylcholine
transporter,
vasoactive
intestinal
peptide;
immunofluorescence
staining),
morphometric
parameters
(histological
analysis).
Under
influence
MP-PET,
there
was
reduction
CART-
GAL-positive
neurons
submucosal
plexuses
nNOS-,
VAChT-,
VIP-positive
all
plexuses.
In
contrast,
increase
myenteric
plexus
SP-positive
IL-1β,
TNF-α
did
not
undergo
statistically
significant
changes
under
low
high
MP-PET.
histological
structure
exclusively
concerned
thinning
mucosa
muscularis
externa.
results
support
thesis
MP-PET
neutral
ileal
cells.
