Interaction Between Liver Metabolism and Gut Short-Chain Fatty Acids via Liver–Gut Axis Affects Body Weight in Lambs DOI Open Access
Haibo Wang, Jinshun Zhan,

Shengguo Zhao

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13386 - 13386

Опубликована: Дек. 13, 2024

The gut–liver axis and its interactions are essential for host physiology. Thus, we examined the jejunal microbiota, fermentation parameters, digestive enzymes, morphology, liver metabolic profiles in different growth development lambs to investigate liver–gut axis’s role their development. One hundred male Hu of similar birth weight age were raised under same conditions until they reached 180 days age. Subsequently, eight with highest (HADG) lowest (LADG) average daily gains slaughtered index assessment. study indicates that body weight, carcass propanoic acid, butyric acid ratio, enzymes (beta-glucosidase, microcrystalline cellulase, xylanase, carboxymethyl cellulase) significantly higher HDAG than LADG (p < 0.05). Additionally, there no significant differences microbiota’s structure function among at stages > Overall, our analysis revealed HADG compared exhibited an up-regulation metabolites (such as spermine, cholic succinic betaine, etc.) positively correlated beta-glucosidase, amylase, while these negatively kidney, acetic acid/ ratio. Furthermore, was a correlation between metabolism microbiota. This hepatic stages, which may inform targeted regulation strategies enhance lamb productivity.

Язык: Английский

Metagenomics-Metabolomics Exploration of Three-Way-Crossbreeding Effects on Rumen to Provide Basis for Crossbreeding Improvement of Sheep Microbiome and Metabolome of Sheep DOI Creative Commons

Haibo Wang,

Jinshun Zhan, Haoyun Jiang

и другие.

Animals, Год журнала: 2024, Номер 14(15), С. 2256 - 2256

Опубликована: Авг. 3, 2024

The objective of this experiment was to explore the effects three-way hybridization on rumen microbes and metabolites in sheep using metagenomics metabolomics. Healthy Hu CAH (Charolais × Australian White Hu) male lambs similar birth weight age were selected for short-term fattening after intensive weaning collect fluid sequencing. Rumen diversity showed that significantly segregated at species, KEGG-enzyme, CAZy-family levels. Moreover, increased ACE Chao1 indices. Further, correlation analysis abundance top 80 revealed microorganisms interrelated Overall, microbiome affected five pathways, with strongest found succinic acid. Meanwhile, species-level microbial markers differential metabolites. In addition, overall positively correlated down-regulated negatively up-regulated contrast, These results suggest crossbreeding affects community metabolite composition, significant interactions exist between

Язык: Английский

Процитировано

4
Microbial–Metabolomic Exploration of Tea Polyphenols in the Regulation of Serum Indicators, Liver Metabolism, Rumen Microorganisms, and Metabolism in Hu Sheep DOI Creative Commons
Haibo Wang, Jinshun Zhan,

Shengguo Zhao

и другие.

Animals, Год журнала: 2024, Номер 14(18), С. 2661 - 2661

Опубликована: Сен. 12, 2024

This study investigated the impact of tea polyphenols on serum indices, rumen microorganisms, metabolism, and liver metabolism in Hu sheep. Sixty healthy lambs, aged three months with similar average weights, were chosen randomly assigned to control (CON), TP400, TP800, TP1200 groups, each consisting fifteen lambs. The group received a basal diet, while experimental groups provided diet supplemented 400 mg/kg, 800 1200 mg/kg polyphenols, respectively. Compared CON group, addition significantly increased IgA, GSH-Px, TSOD. In addition, able increase pH but had no significant effect NH

Язык: Английский

Процитировано

3
Genomic dissection of high-temperature resistance in hybrid oysters (Crassostrea gigas ♀ × C. angulata ♂) using SNP- and InDel-GWAS based on whole-genome resequencing DOI

Shi-qi Dou,

Gaowei Jiang,

Ben Yang

и другие.

Aquaculture, Год журнала: 2025, Номер unknown, С. 742310 - 742310

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
A Comparison Between High- and Low-Performing Lambs and Their Impact on the Meat Quality and Development Level Using a Multi-Omics Analysis of Rumen Microbe–Muscle–Liver Interactions DOI Creative Commons
Haibo Wang, Jinshun Zhan,

Shengguo Zhao

и другие.

Microorganisms, Год журнала: 2025, Номер 13(4), С. 943 - 943

Опубликована: Апрель 19, 2025

Through an integrated multi-omics analysis of rumen microbial communities, muscle transcriptomes, metabolic profiles, and liver this study systematically compared high- low-performing lambs to elucidate their divergent effects on meat quality attributes growth development. A total 100 male with similar birth weight (3.07 ± 0.06 kg) were selected within 72 h. All test synchronized weaning at 45 days age uniformly fed the same diet (total mixed ration) in pen until 180 age, ad libitum access food water throughout period. Subsequently, eight highest (HADG) lowest (LADG) average daily gains slaughtered for performance evaluation analysis. This found that HADG increased body weight, fiber diameter, eye area, improved amino acid (histidine, arginine, valine, isoleucine, essential acid/total acid, acid/nonessential acid), fatty (linoleic behenic arachidonic acid) composition enhanced enzymes (pepsase, lipase, xylanase, amylase, carboxymethyl cellulose) promoted efficient fermentation (p < 0.05). Analysis populations indicated a notable increase Prevotella levels lambs. Furthermore, markers Schwartzia Streptococcus exhibited significant correlations differential traits. transcriptome correlation between turquoise module host phenotypes, particularly weight. Additionally, metabolism is primarily concentrated black module; however, it exhibits phenotype yellow Moreover, metabolites, microbes, phenotype, transcripts significantly correlated In conclusion, interactions among muscle, promote fermentation, which turn regulate transcriptional activity modify profiles both muscle. PCK1, SPP1, FGF7, NR4A1, DUSP5, GADD45B, etc., can be candidate genes finding provides theoretical basis further exploiting production potential Hu

Язык: Английский

Процитировано

0
Discrepancies in the rumen microbiome, metabolome, and serum metabolome among Hu sheep, East Friesian sheep, and East Friesian × Hu crossbred sheep DOI Creative Commons

Ruilin Du,

Shuo Yan,

Wenna Yao

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 28, 2025

Crossbreeding has emerged as a strategy to combine desirable traits from different sheep breeds, with the goal of enhancing productivity, disease resistance, and growth rates. This study compares immune responses, rumen microbiomes, serum metabolites Hu sheep, East Friesian (EF) crossbred × EF (DH) explore effects crossbreeding on productivity resistance. exhibited significantly higher lymphocyte counts (p < 0.05) white blood cell (WBC) compared DH indicating stronger basal responses. showed superior cluster differentiation 4+/cluster 8+ (CD4+/CD8+) T ratio sheep. Rumen microbiome analysis revealed distinct microbial profiles; relative abundances Prevotella 0.05), which is associated improved Metabolomic significant differences in bile acid profiles: levels 6-keto lithocholic (6-ketoLCA), cholic chenodeoxycholic (CDCA), 3β-hyodeoxycholic (3β-HDCA) function gut health. These results indicate that improves resilience metabolic efficiency, implications for breeding strategies designed enhance livestock

Язык: Английский

Процитировано

0
Sex-induced alterations in rumen microbial communities and metabolite profiles: implications for lamb body weight DOI Creative Commons
Haibo Wang, Jinshun Zhan,

Shengguo Zhao

и другие.

BMC Microbiology, Год журнала: 2025, Номер 25(1)

Опубликована: Май 27, 2025

Язык: Английский

Процитировано

0
Interaction Between Liver Metabolism and Gut Short-Chain Fatty Acids via Liver–Gut Axis Affects Body Weight in Lambs DOI Open Access
Haibo Wang, Jinshun Zhan,

Shengguo Zhao

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13386 - 13386

Опубликована: Дек. 13, 2024

The gut–liver axis and its interactions are essential for host physiology. Thus, we examined the jejunal microbiota, fermentation parameters, digestive enzymes, morphology, liver metabolic profiles in different growth development lambs to investigate liver–gut axis’s role their development. One hundred male Hu of similar birth weight age were raised under same conditions until they reached 180 days age. Subsequently, eight with highest (HADG) lowest (LADG) average daily gains slaughtered index assessment. study indicates that body weight, carcass propanoic acid, butyric acid ratio, enzymes (beta-glucosidase, microcrystalline cellulase, xylanase, carboxymethyl cellulase) significantly higher HDAG than LADG (p < 0.05). Additionally, there no significant differences microbiota’s structure function among at stages > Overall, our analysis revealed HADG compared exhibited an up-regulation metabolites (such as spermine, cholic succinic betaine, etc.) positively correlated beta-glucosidase, amylase, while these negatively kidney, acetic acid/ ratio. Furthermore, was a correlation between metabolism microbiota. This hepatic stages, which may inform targeted regulation strategies enhance lamb productivity.

Язык: Английский

Процитировано

2