Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas
Animals,
Год журнала:
2025,
Номер
15(2), С. 264 - 264
Опубликована: Янв. 18, 2025
Transferrin
Receptor
2
(TfR2)
is
a
homolog
of
1
(TfR1),
involved
in
regulating
intra
and
extracellular
iron
levels.
Altered
pathways
have
been
associated
with
cancer
onset
progression;
however,
their
role
canine
tumors
remains
poorly
explored.
This
study
investigated
TfR2
immunohistochemical
expression
non-neoplastic
testis
for
the
first
time
most
common
types
testicular
tumors:
intratubular
seminomas
(ITSEMs),
diffuse
(DSEMs),
Leydig
cell
(LCTs),
Sertoli
(SCTs).
Immunohistochemical
analysis
revealed
differential
pattern
according
to
tumor
type,
high
observed
ITSEMs
DSEMs,
occasional
LCTs,
absence
SCTs.
These
results
suggest
that
may
play
relevant
seminoma
development.
Furthermore,
specific
highlights
its
potential
as
therapeutic
target,
where
regulation
possible
compensatory
mechanisms
warrant
further
investigation.
Язык: Английский
Ferritinophagy: a possible new iron-related metabolic target in canine osteoblastic osteosarcoma
Frontiers in Veterinary Science,
Год журнала:
2025,
Номер
12
Опубликована: Март 24, 2025
Canine
osteosarcomas
(COS)
are
the
most
common
bone
tumors
in
dogs,
characterized
by
high
metastatic
rates,
poor
prognosis,
and
responsiveness
to
routine
therapies,
which
highlights
need
for
new
treatment
targets.
In
this
context,
metabolism
of
neoplastic
cells
represents
an
increasingly
studied
element,
as
cancer
depend
on
particular
metabolic
pathways
that
also
elements
vulnerability.
Among
these,
tumor
(TCs)
show
higher
iron
requirements
sustain
proliferation
(so-called
addiction),
achieved
increasing
uptake
and/or
activating
ferritinophagy,
a
process
mediated
Nuclear
receptor
Co-Activator
4
(NCOA4)
leading
mobilization
from
ferritin
(Ft)
deposits.
Previous
studies
have
shown
COS
overexpress
Transferrin
Receptor
1
(TfR1)
increase
uptake.
study
we
evaluated
immunohistochemical
expression
ferritinophagy-related
proteins,
namely
Ferritin
Heavy
chain
(FTH1)
NCOA4,
proliferating
cell
nuclear
antigen
(PCNA)
canine
normal
osteoblastic
osteosarcoma
(COOS)
samples.
Normal
samples
revealed
negative/weak
immunoreactivity
FTH1,
NCOA4
PCNA
<10%
osteocytes.
COOS
majority
showed
PCNA.
Our
data
suggest
activation
ferritinophagy
responds
feed
their
“iron
addiction.”
These
data,
though
preliminary,
further
targeting
potential
strategy
worthy
be
transferred
into
clinical
practice.
Язык: Английский
From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health
Metabolites,
Год журнала:
2025,
Номер
15(4), С. 267 - 267
Опубликована: Апрель 11, 2025
Background/Objectives:
Inflammation,
infections,
and
oxidative
stress
(OS)
all
have
an
impact
on
male
infertility,
which
is
a
complicated,
multifaceted
illness.
OS
affects
motility
fertilization
capability.
It
accomplishes
this
through
damaging
sperm
DNA,
oxidizing
proteins,
triggering
lipid
peroxidation.
These
effects
occur
due
to
imbalance
between
reactive
oxygen
species
(ROS)
antioxidant
defenses.
Methods:
This
review
aims
evaluate
the
of
inflammation
infertility
by
assessing
recent
literature.
Results:
Pro-inflammatory
cytokines,
like
TNF-α
IL-6,
interfere
with
spermatogenesis
promote
damage.
Additionally,
infections
caused
pathogens
Escherichia
coli
Chlamydia
trachomatis
alter
reproductive
microenvironment,
leading
dysfunction
inflammation.
Conclusions:
Early
detection
targeted
treatment
are
essential
intricate
interactions
among
these
elements.
Microbiota-modulating
techniques,
antimicrobial
therapies,
anti-inflammatory
drugs,
antioxidants
therapeutic
approaches
that
may
help
reduce
damage
enhance
fertility.
Язык: Английский