Genome-Wide Association Study (GWAS) on Reproductive Seasonality in Indigenous Greek Sheep Breeds: Insights into Genetic Integrity DOI Creative Commons
Danai Antonopoulou, George Symeon, Konstantinos Zaralis

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 279 - 279

Опубликована: Апрель 16, 2025

A key feature in sheep biology is reproduction seasonality which concerns the cyclical occurrence of natural breeding, therefore does not take place throughout year. Since are short-day breeders, amount daylight has an impact on their reproductive activity. The melatonin receptor subtype 1A (MTNR1A) gene primary that been linked with seasonality. Nonetheless, information regarding potential genetic association between other loci and scarce. Genome-wide study (GWAS) considered a cutting-edge methodology for comprehending architecture complex traits since it enables discovery many markers to different features. In present study, three indigenous Greek breeds were investigated using GWAS—two presented strict patterns seasonality, i.e., Florina Karagkouniko breeds, while third one, Chios breed had ability exhibit estrus year—in attempt detect All animals purebred originating from national stationary stock, whereas originated commercial farm. Interestingly, significant differentiation stock groups was suggested by principal component analysis, phylogenetic admixture spatial point patterns, these two being less heterogeneous. This finding highlights value stocks towards maintenance integrity sheep, demonstrating station’s critical role conservation native breeds. On hand, according GWAS data no correlated emphasizing MTNR1A as main determinant non genetically improved

Язык: Английский

Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats DOI Creative Commons
Qing Li, Tianle Chao, Yanyan Wang

и другие.

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Март 28, 2025

The hypothalamus is a critical organ that regulates sexual development in animals. However, current research on the hypothalamic regulation of maturation female goats remains limited. In this study, we conducted metabolomic and transcriptomic analyses tissues Jining grey at different stages (1 day old (neonatal, D1, n = 5), 2 months (prepuberty, M2, 4 (sexual maturity, M4, 6 (breeding period, M6, 5)). A total 418 differential metabolites (DAMs) were identified among which abundance such as anserine, L-histidine, carnosine, taurine, 4-aminobutyric gradually increased with progression development. These may regulate neuronal hormone secretion processes by influencing metabolism histidine phenylalanine. Through combined analyses, differentially expressed genes mitogen-activated protein kinase 9 (MAP3K9), prune homolog BCH domain (PRUNE2), potassium voltage-gated channel interacting 4(KCNIP4) jointly energy Gonadotropin-releasing neurons conjunction DAMs, including LPC22:5, 2-Arachidonyl Glycerol ether, LPE22:5, Lysops22:5. Additionally, elucidated molecular mechanism through glutathione goats. summary, study illustrates dynamic changes mRNA within tissue during postnatal This provide significant scientific insights for future animal breeding.

Язык: Английский

Процитировано

0
Genome-Wide Association Study (GWAS) on Reproductive Seasonality in Indigenous Greek Sheep Breeds: Insights into Genetic Integrity DOI Creative Commons
Danai Antonopoulou, George Symeon, Konstantinos Zaralis

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 279 - 279

Опубликована: Апрель 16, 2025

A key feature in sheep biology is reproduction seasonality which concerns the cyclical occurrence of natural breeding, therefore does not take place throughout year. Since are short-day breeders, amount daylight has an impact on their reproductive activity. The melatonin receptor subtype 1A (MTNR1A) gene primary that been linked with seasonality. Nonetheless, information regarding potential genetic association between other loci and scarce. Genome-wide study (GWAS) considered a cutting-edge methodology for comprehending architecture complex traits since it enables discovery many markers to different features. In present study, three indigenous Greek breeds were investigated using GWAS—two presented strict patterns seasonality, i.e., Florina Karagkouniko breeds, while third one, Chios breed had ability exhibit estrus year—in attempt detect All animals purebred originating from national stationary stock, whereas originated commercial farm. Interestingly, significant differentiation stock groups was suggested by principal component analysis, phylogenetic admixture spatial point patterns, these two being less heterogeneous. This finding highlights value stocks towards maintenance integrity sheep, demonstrating station’s critical role conservation native breeds. On hand, according GWAS data no correlated emphasizing MTNR1A as main determinant non genetically improved

Язык: Английский

Процитировано

0