Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed DOI Open Access
Janelle M. Belanger, Liza Gershony,

Jerold S. Bell

и другие.

Genes, Год журнала: 2025, Номер 16(4), С. 378 - 378

Опубликована: Март 27, 2025

Background: Genetic diversity in closed populations, such as pedigree dogs, is of concern for maintaining the health and vitality population face evolving challenges. Measures genetic rely upon estimates homozygosity without consideration whether desirable or undesirable if heterozygosity has a functional impact. Pedigree coefficients inbreeding have been classical approach yet they are inadequate unless based entire population. Methods: Homozygosity measures analyses (n = 11,898), SNP array data 244), whole genome sequencing 23) were compared Bearded Collie, well comparison to cohort 5042) mixed-breed 1171). Results: Molecular DNA more informative on an individual’s levels than analyses, although overestimate level nature methodology. Whole sequence (WGS) revealed that observed generally variants having neutral low impact, which would indicate variability may not contribute substantially The majority high-impact shortest runs (ROH) reflecting ancestral breeding domestication practices. As expected, dogs displayed higher genomic either Collies other using current paradigm algorithm models calculate homozygosity. Conclusions: Using typical DNA-based reflect only single individual thereby failing account regions breeding, history, breed-defining regions, positively selected traits. Incorporating into dog schemes meritorious. However, until can distinguish between associated with positive alleles, use selection tools need refinement before their widespread implementation.

Язык: Английский

Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed DOI Open Access
Janelle M. Belanger, Liza Gershony,

Jerold S. Bell

и другие.

Genes, Год журнала: 2025, Номер 16(4), С. 378 - 378

Опубликована: Март 27, 2025

Background: Genetic diversity in closed populations, such as pedigree dogs, is of concern for maintaining the health and vitality population face evolving challenges. Measures genetic rely upon estimates homozygosity without consideration whether desirable or undesirable if heterozygosity has a functional impact. Pedigree coefficients inbreeding have been classical approach yet they are inadequate unless based entire population. Methods: Homozygosity measures analyses (n = 11,898), SNP array data 244), whole genome sequencing 23) were compared Bearded Collie, well comparison to cohort 5042) mixed-breed 1171). Results: Molecular DNA more informative on an individual’s levels than analyses, although overestimate level nature methodology. Whole sequence (WGS) revealed that observed generally variants having neutral low impact, which would indicate variability may not contribute substantially The majority high-impact shortest runs (ROH) reflecting ancestral breeding domestication practices. As expected, dogs displayed higher genomic either Collies other using current paradigm algorithm models calculate homozygosity. Conclusions: Using typical DNA-based reflect only single individual thereby failing account regions breeding, history, breed-defining regions, positively selected traits. Incorporating into dog schemes meritorious. However, until can distinguish between associated with positive alleles, use selection tools need refinement before their widespread implementation.

Язык: Английский

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