Applied Sciences,
Год журнала:
2021,
Номер
11(18), С. 8477 - 8477
Опубликована: Сен. 13, 2021
Phytonutrients
are
plant
foods
that
contain
many
natural
bioactive
compounds,
called
phytochemicals,
which
show
specific
biological
activities.
These
phytonutrients
and
their
phytochemicals
may
play
an
important
role
in
health
care
maintaining
normal
organism
functions
(as
preventives)
fighting
against
diseases
therapeutics).
Phytonutrients’
components
the
primary
metabolites
(i.e.,
proteins,
carbohydrates,
lipids)
or
secondary
phenolics,
alkaloids,
organosulfides,
terpenes).
For
years,
several
have
demonstrated
pharmacological
therapeutic
effects
human
such
as
anticancer,
antioxidant,
antiviral,
anti-inflammatory,
antibacterial,
antifungal,
immune
response.
This
review
summarizes
of
most
studied
popular
turmeric,
garlic,
cinnamon,
graviola,
oregano)
any
reported
contraindications.
article
also
presents
calculated
physicochemical
properties
main
selected
using
Lipinski’s,
Veber’s,
Ghose’s
rules.
Based
on
our
revisions
for
this
article,
all
these
consistently
shown
great
potential
preventives
therapeutics
vitro,
vivo,
clinical
studies.
Journal of Animal Physiology and Animal Nutrition,
Год журнала:
2024,
Номер
108(3), С. 839 - 853
Опубликована: Фев. 7, 2024
Abstract
This
experiment
was
designed
to
investigate
the
impact
of
curcumin‐olive
oil
nanocomposite
(CONC)
supplementation
on
uteroplacental
hemodynamics
and
ultrasonographic
measurements
as
well
maternal
oxidative
status
in
midgestating
goats.
Twelve
synchronized
pregnant
goats
(85.58
±
1.08
days
gestation;
mean
SD)
were
uniformly
assigned
two
groups
(
n
=
6/group);
first
group
received
daily
oral
CONC
(3
mg/kg
body
weight;
nanocurcumin
[NC]
group)
for
32
days,
second
offered
physiological
saline
(control)
following
NC
timeline.
The
both
examined
at
3‐day
intervals
middle
uterine
(MUA)
umbilical
(UMA)
arteries
(pulsatility
index
[PI],
resistive
[RI],
systole/diastole
[S/D]
blood
flow
rate
[BFR])
diameters,
thickness
(UPT),
placentomes'
diameter
(PD)
echogenicity,
steroid
hormones
(progesterone
estradiol
17β),
biomarkers
(total
antioxidant
capacity
[TAC],
catalase
[CAT],
malondialdehyde
[MDA]),
nitric
oxide
(NO)
cells
DNA
integrity.
UPT
p
0.012)
PD
0.021)
values
higher
than
their
counterparts'
control
(D11–32).
There
increases
0.021
decreases
0.021,
0.016
0.041
[MUA];
0.015,
0.023
0.011
[UMA]
respectively)
Doppler
indices
(PI,
RI
S/D)
MUA
UMA
compared
(D14–32).
On
D20–32
D14–32
(UMA),
had
BFR
0.018
respectively).
means
with
fragmented
lower
0.022)
Days
8
21
postsupplementation.
CAT
NO
(D20–32;
0.022
0.004
respectively),
TAC
(D17–32;
0.007)
levels
ones.
0.029)
concentrations
MDA
Day
20
postsupplementation
onward.
In
conclusion,
improved
Veterinary Sciences,
Год журнала:
2025,
Номер
12(3), С. 250 - 250
Опубликована: Март 6, 2025
This
study
evaluated
the
effects
of
a
botanical
supplement
(a
formulated
proprietary
blend
turmeric,
capsicum,
and
black
pepper
oleoresin
in
fat
carrier;
PHYT),
fed
pre-
post-calving,
on
colostrum
milk
yield
quality,
passive
transfer
immunity,
performance
cow–calf
pairs.
Twenty-three
(BW
=
532
±
9.13
kg;
age
36
mo)
crossbred
Angus
cows
were
randomly
assigned
to
three
treatment
groups:
(1)
not
supplemented
(CON,
n
7);
(2)
with
250
mg/head/day
(PHYT250,
8);
or
(3)
500
(PHYT500,
8)
supplement.
The
individually
from
30
days
(±6
days)
pre-calving
60
post-calving.
Colostrum
was
collected
d
0
(pre-suckling),
1,
2,
3
total
all
quarters
45
90
post-calving
at
weaning.
volumes
recorded,
samples
analyzed
for
percentages
fat,
protein,
urea
nitrogen,
other
solids,
lactose.
concentrations
IgG,
IgA,
IgM,
IgG
concentration
using
radial
immunodiffusion.
Blood
dams
calves,
serum
(cows
calves)
IgA
(calves).
Cow
calf
BW
measured
periodically
until
Supplementation
PHYT
linearly
increased
(CON
3.29,
PHIT250
4.23,
PHYT500
4.17
0.77%;
p
0.05)
(96.91,
151.69,
183.42
29.78
mg/dL
CON,
PHYT250,
PHYT500,
respectively;
0.04)
tended
increase
3.84,
PHYT250
4.05,
4.71
1.04%;
0.07),
(2082.31;
2196.29;
2577.78
213.08
0.09),
IgM
179.04;
170.79;
218.30
16.08
mg/dL;
0.09).
A
quadratic
response
observed
ADG
(p
0.03),
where
CON
(0.99
0.03
kg/d)
less
than
(1.10
kg/d),
intermediate
values
(1.01
kg/d).
In
summary,
supplementation
led
linear
levels
serum.
Additionally,
elevate
milk,
serum,
colostrum.
Our
results
suggest
that
supplementing
beef
late
gestation
early
lactation
mg/head/d
improves
quality
health
performance.
Further
investigation
is
needed
determine
both
biological
significance
economic
benefits
additives
production.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11905 - 11905
Опубликована: Окт. 7, 2022
Curcumin
(CUR)
is
a
kind
of
natural
orange-yellow
phenolic
compound
mainly
extracted
from
the
stems
and
roots
turmeric
plants
other
species
in
genus
Curcuma,
furthermore,
it
also
most
important
active
ingredient
exerting
pharmacological
functions
turmeric.
In
recent
years,
CUR
has
been
frequently
reported
attracted
widespread
attention
scholars
all
over
world
due
to
its
numerous
biological
good
application
prospects,
such
as
anti-inflammatory,
anticancer,
antioxidant
providing
lipid-lowering
effects,
etc.
addition,
adding
certain
dose
livestock
poultry
feed
for
animal
growth
development,
which
plays
key
role
metabolism,
reproduction,
immunity
clinical
health
care.
This
review
aims
summarize,
based
on
published
papers
our
own
observations,
physical
chemical
properties
plant-derived
bioactive
CUR,
especially
regarding
latest
research
progress
regulating
intestinal
well
current
development
future
prospects
novel
additive,
so
provide
theoretical
practical
references
further
study
additive
potential
new
antibiotic
substitute,
thereby
improving
field
ingredients
promoting
healthy
poultry.
Scientific Reports,
Год журнала:
2020,
Номер
10(1)
Опубликована: Сен. 25, 2020
Abstract
Schistosomiasis
is
a
serious
parasitic
infection
affecting
millions
worldwide.
This
study
aimed
to
explore
the
anti-schistosomal
activity
of
curcumin
and
loaded
gold-nanoparticles
(Cur-GNPs)
with
or
without
praziquantel
(PZQ).
We
used
six
groups
C57BL/6
mice
in
which
five
were
infected
Schistosoma
Mansoni
(S.
mansoni)
cercariae
exhibited,
separately,
different
treatment
regimens
curcumin,
nanoparticle,
PZQ,
addition
one
untreated
group
acts
as
control.
Mice
sacrificed
at
8th
week
where
both
worms
eggs
counted
hepatic
porto-mesenteric
vessels
liver
intestine,
respectively,
histopathological
examination
granuloma.
Curcumin
caused
significant
reduction
egg
count
(45.45%)
3rd
week.
A
schistosomicidal
effect
PZQ
was
found
all
groups.
Cur-GNPs
combined
97.4%
worm
burden
highest
intestinal
content,
well,
besides
70.1%
granuloma
size.
The
results
suggested
combination
strong
regimen
against
S.
mansoni
it
alters
hematological,
biochemical,
immunological
changes
induced.
Environmental Toxicology,
Год журнала:
2022,
Номер
38(2), С. 300 - 311
Опубликована: Окт. 28, 2022
To
investigate
curcumin's
protective
effect
on
nerve
damage
caused
by
ketamine
anesthesia
via
the
Nrf2
signaling
pathway.
Rats
and
PC12
cells
were
used
in
this
experiment
to
mechanism
of
injury
anesthesia.
Furthermore,
our
findings
suggest
that
curcumin
may
affect
oxidative
stress
apoptosis
targeting
pathway,
thereby
alleviating
ketamine.The
rat
cerebral
cortex
hippocampus
stained
with
Nissl
immunohistochemistry
determine
number
neurons
expression
Caspase-3,
Bcl-2,
Bax.
CCK-8
assay
was
optimal
concentration
ketamine,
curcumin,
H2
O2
cells.
Flow
cytometry
detect
changes
reactive
oxygen
species
rate
each
group.
whether
entered
nucleus,
immunofluorescence
used.
Both
tissues
subjected
RT-PCR
Western
blotting
detection
at
same
time.
The
levels
determined
using
a
malondialdehyde
(MDA)
superoxide
dismutase
(SOD)
kit.Ketamine
reduced
rats.
proteins
Bax
Caspase-3
upregulated,
while
Bcl-2
down-regulated
hippocampus.
viability
has
decreased.
MDA
content
increased
SOD
activity
decreased
cortex,
hippocampus,
Ketamine
had
an
some
genes
pathway
as
well
apoptosis.
Curcumin
pretreatment
be
able
prevent
ketamine-induced
damage.The
during
growth
activation
Our
research
provides
potential
strategy
for
secure
administration
anesthetics
medical
settings.
