Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

Frontiers in Veterinary Science, Год журнала: 2018, Номер 5

Опубликована: Июль 23, 2018

Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety analgesic efficacy a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Methods: Single-dose pharmacokinetics was performed using two different doses CBD enriched (2 8 mg/kg) oil. Thereafter, randomized placebo-controlled, veterinarian, owner blinded, cross-over conducted. Dogs received each treatments: or placebo every 12 h. Each treatment lasted for 4 weeks 2-week washout period. Baseline veterinary assessment questionnaires completed before initiating at 2 4. Hematology, serum chemistry physical examinations visit. A mixed model analysis, analyzing the change from enrollment baseline all other time points utilized variables interest, p ≤ 0.05 defined as significant. Results: Pharmacokinetics revealed an elimination half-life 4.2 h both no observable side effects. Clinically, canine brief pain inventory Hudson activity scores showed significant decrease increase (p < 0.01) Veterinary decreased during 0.02). No effects reported by owners, however, alkaline phosphatase 0.01). Clinical significance: This pharmacokinetic clinical suggests that mg/kg twice daily can help comfort OA.

Язык: Английский

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Cannabidiol (CBD) as a Promising Anti-Cancer Drug

Cancers, Год журнала: 2020, Номер 12(11), С. 3203 - 3203

Опубликована: Окт. 30, 2020

Recently, cannabinoids, such as cannabidiol (CBD) and Δ

Язык: Английский

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A Review of Hemp as Food and Nutritional Supplement

Cannabis and Cannabinoid Research, Год журнала: 2020, Номер 6(1), С. 19 - 27

Опубликована: Апрель 9, 2020

The term "hemp" refers to Cannabis sativa cultivars grown for industrial purposes that are characterized by lower levels of tetrahydrocannabinol (THC), the active principle responsible psychotropic effects. Hemp is an extraordinary crop, with enormous social and economic value, since it can be used produce food, textiles, clothing, biodegradable plastics, paper, paint, biofuel, animal feed, as well lighting oil. Various parts hemp plant represent a valuable source food ingredients nutritional supplements. While inflorescence rich in nonpsychoactive, yet biologically cannabinoids, such cannabidiol (CBD), which exerts potent anxiolytic, spasmolytic, anticonvulsant effects, hempseed has pleasant nutty taste represents essential amino acids fatty acids, minerals, vitamins, fibers. In addition, oil healthy polyunsaturated sprouts antioxidants. This review article aims provide comprehensive outlook from multidisciplinary perspective on scientific evidence supporting beneficial properties when consumed or supplement. Marketing hemp-derived products subjected diversified complex regulations worldwide several reasons, including fact CBD also principal pharmaceutical agents regulatory bodies some cases ban regardless its THC content. Some key aspects scenario analyzed discussed this article.

Язык: Английский

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2022 WSAVA guidelines for the recognition, assessment and treatment of pain

Journal of Small Animal Practice, Год журнала: 2022, Номер 64(4), С. 177 - 254

Опубликована: Окт. 27, 2022

Abstract Animal sentience refers to the capacity of animals feel both positive and negative emotions including that pain. As veterinary health professionals, we have a medical ethical duty mitigate suffering from pain best our ability. In 2014, first Global Pain Council World Small Veterinary Association (WSAVA) Guidelines for Recognition, Assessment Treatment was published remains this day one most relevant widespread documents its kind. The 2022 WSAVA Management evolves document with updated scientific information reflecting major advances in medicine last decade. This is designed provide user easy‐to‐implement, core fundamentals on successful recognition treatment day‐to‐day small animal clinical practice setting. It provides basic practical an extensive reference list guide those who want further their knowledge management. should be easily implemented regardless setting and/or location promotion advance management welfare.

Язык: Английский

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Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis

Animals, Год журнала: 2020, Номер 10(9), С. 1505 - 1505

Опубликована: Авг. 26, 2020

The aim of this study was to evaluate the efficacy oral transmucosal (OTM) cannabidiol (CBD), in addition a multimodal pharmacological treatment for chronic osteoarthritis-related pain dogs. Twenty-one dogs were randomly divided into two groups: group CBD (n = 9), OTM (2 mg kg-1 every 12 h) included therapeutic protocol (anti-inflammatory drug, gabapentin, amitriptyline), while C 12), not administered. Dogs evaluated by owners based on Canine Brief Pain Inventory scoring system before initiation (T0), and one (T1), (T2), four (T3) twelve (T4) weeks thereafter. Severity Score significantly lower than at T1 (p 0.0002), T2 0.0043) T3 0.016). Interference 0.0007) T4 0.004). Quality Life Index higher 0.003). showed promising results. Further pharmacokinetics long-term studies larger populations are needed encourage its inclusion approach canine pain.

Язык: Английский

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Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract

Frontiers in Veterinary Science, Год журнала: 2020, Номер 7

Опубликована: Сен. 4, 2020

Hemp extract use is increasing in veterinary medicine with little examination of serum cannabinoids. Many products contain small amounts 9-tetrahydrocannabinol (THC), and precursor carboxylic acid forms CBD THC known as cannabidiolic (CBDA) tetrahydrocannabinolic (THCA). Examination the pharmacokinetics CBD, CBDA, THCA on three oral hemp that contained near equal dogs was performed. In addition, we assess metabolized psychoactive component THC, 11-hydroxy-9-tetrahydrocannabinol (11OH-THC) metabolites 7-hydroxycannabidiol (7OH-CBD) 7-nor-7 carboxycannabidiol (7COOH-CBD) to better understand pharmacokinetic differences between formulations regarding their metabolism. Six purpose bred female beagles were utilized for study purposes, each having an initial 7-point, 24 hour performed using a dose 2 mg/kg body weight CBD/CBDA (~1 ~1 CBDA), then dosed every 12 hours weeks had further analyses at week 1 2, 6 after morning Serum analyzed cannabinoid or metabolite liquid chromatography tandem mass spectroscopy (LC-MS/MS). Regardless oil form, chew provided, 24-hour similar, only B generating enough data within lower limit quantitation THC. CBDA concentrations two three-fold higher than concentrations, respectively. The one- two-week steady state not significantly different oils soft forms. statistically other forms, showing superior absorption/retention CBDA. Furthermore, A showed less retention either 2. 11OH-THC below assay nearly all samples. Overall, these findings suggest are absorbed eliminated differently respectively, partial lecithin base provides absorption and/or THCA.

Язык: Английский

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Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs

Scientific Reports, Год журнала: 2021, Номер 11(1)

Опубликована: Фев. 2, 2021

Among the phytocomplex components of Cannabis sativa L., cannabidiol (CBD) has a recognised therapeutic effect on chronic pain. Little is known about veterinary use CBD in dogs. Even less effects dog behaviour, especially shelters. The purpose this study was to determine if affects stress related behaviour shelter sample consisted 24 dogs divided into two groups that were created by assigning alternately: 12 assigned treatment group and control group. Extra virgin olive oil, titrated 5% given treated group; placebo oil only, dispensed daily for 45 days. Behavioural data collected using 'focal animal' sampling method with 'all occurrences' '1/0' methods 3 h: before (T0), after 15 days (T1), (T2) from end (T3). Treated showed reduced aggressive toward humans following (Friedman Test: χ2 = 13.300; df 3; N 12; p .004; adj. sig. 0.027), but difference decrease between not significant (Mann-Whitney U test, T2-T0: Z - 1.81; 24; 0.078). Other behaviours indicative stress, such as displacing activities stereotypes, did decrease. Despite some non-significant results, our findings suggest it worth doing more research further investigate behaviour; would be certainly valuable because potential improving welfare shelters priceless.

Язык: Английский

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Evaluation of the Effect of Cannabidiol on Naturally Occurring Osteoarthritis-Associated Pain: A Pilot Study in Dogs

Journal of the American Animal Hospital Association, Год журнала: 2021, Номер 57(2), С. 81 - 90

Опубликована: Янв. 15, 2021

ABSTRACT The objective of this study was to provide preliminary data describing the safety and effect cannabidiol (CBD) for symptom relief canine osteoarthritis-associated pain in a clinical setting using outcome measures. Twenty-three client-owned dogs with naturally occurring osteoarthritis appendicular joints completed prospective, double-blinded, crossover, placebo-controlled study. Baseline were acquired 4 wk, followed by random allocation either placebo or CBD treatment 6 wk opposite treatment. Outcome measures included gait analysis, activity counts (via accelerometry) metrology instruments. There no differences noted between groups at any time point recorded Adverse events associated administration elevation liver enzymes (n = 14) vomiting 2).

Язык: Английский

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The role of cannabinoids in pain modulation in companion animals

Frontiers in Veterinary Science, Год журнала: 2023, Номер 9

Опубликована: Янв. 4, 2023

The use of cannabinoids in both veterinary and human medicine is controversial for legal ethical reasons. Nonetheless, the availability therapeutic naturally occurring or synthetic phytocannabinoids, such as Δ 9 -tetrahydrocannabidiol cannabidiol, have been focus attention studies regarding their medical uses. This review aims to examine role pain modulation by analyzing scientific findings signaling pathways endocannabinoid system discussing analgesic effects compared cannabinoid extracts extent involvement receptors. In animals, shown properties these substances binding −1 (CB1) −2 (CB2) receptors modulate acute, chronic neuropathic pain. consists three main components: endogenous ligands (anandamide 2-arachidonoylglycerol), G protein-coupled enzymes that degrade recycle ligands. Evidence suggests interaction with CB1 inhibits causes psychoactive effects. On other hand, CB2 are associated anti-inflammatory reactions on immune system. Cannabis derivatives an effective tool contributes compassionate care participates its multimodal management. However, interacts different neurotransmitters, thus offering possibilities dogs cats, case those patients who suffer from seizures epilepsy, contact atopic dermatitis, degenerative myelopathies, asthma, diabetes glaucoma, among inflammatory diseases. Moreover, compounds possess antineoplastic, appetite-stimulating, antiemetic properties. Ultimately, study system, ligands, receptors, mechanism action, signaling, has contributed development research shows hemp-derived alternative management cats due ability prevent peripheral central sensitization.

Язык: Английский

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Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases

Annual Review of Animal Biosciences, Год журнала: 2023, Номер 11(1), С. 227 - 246

Опубликована: Фев. 15, 2023

Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD increasingly being explored as an alternative to conventional therapies treat health disorders in dogs and cats. Mechanisms action have been investigated mostly rodents vitro include modulation CB1, CB2, 5-HT, GPR, opioid receptors. In companion animals, appears good bioavailability safety profile with few side effects at physiological doses. Some dog studies found improve clinical signs associated osteoarthritis, pruritus, epilepsy. However, further are needed conclude therapeutic for each these conditions, well decreasing anxiety aggression Herein, we summarize available scientific evidence mechanisms CBD, including pharmacokinetics, safety, regulation, efficacy ameliorating various conditions

Язык: Английский

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