From nature to nanomedicine: bioengineered metallic nanoparticles bridge the gap for medical applications

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Май 9, 2024

Abstract The escalating global challenge of antimicrobial resistance demands innovative approaches. This review delves into the current status and future prospects bioengineered metallic nanoparticles derived from natural sources as potent agents. unique attributes abundance resources have sparked a burgeoning field research in combating microbial infections. A systematic literature was conducted, encompassing wide range studies investigating synthesis, characterization, mechanisms nanoparticles. Databases such PubMed, Scopus, Web Science, ScienceDirect, Springer, Taylor & Francis online OpenAthen were extensively searched to compile comprehensive overview topic. synthesis methods, including green sustainable approaches, examined, diverse biological used nanoparticle fabrication. amalgamation products has yielded promising Their multifaceted mechanisms, membrane disruption, oxidative stress induction, enzyme inhibition, render them effective against various pathogens, drug-resistant strains. Moreover, potential for targeted drug delivery systems using these opened new avenues personalized medicine. Bioengineered represent dynamic frontier battle underscores their remarkable efficacy action. Future are bright, with opportunities scalability cost-effectiveness through methods. However, addressing toxicity, regulatory hurdles, environmental considerations remains crucial. In conclusion, this highlights evolving landscape nanoparticles, offering valuable insights revolutionize therapy future. Graphical

Язык: Английский

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Silver Diamine Fluoride in Pediatric Dentistry: Effectiveness in Preventing and Arresting Dental Caries—A Systematic Review

Children, Год журнала: 2024, Номер 11(4), С. 499 - 499

Опубликована: Апрель 22, 2024

Background: Tooth decay is considered a global scourge by the World Health Organization (WHO) starting at an early age. In recent years, silver diamine fluoride (SDF) has regained interest, particularly in pediatric dentistry, used to prevent development of carious lesions or arrest their progression. Objective: The aim this study was assess, through systematic review literature, effectiveness SDF, pedodontics, temporary teeth, preventing arresting dental caries. Material and Methods: An electronic search conducted on PubMed, Web Science Scopus. effect SDF both permanent teeth been considered. Results: inclusion criteria identified 16 randomized controlled trials involving patients aged 18 months 13 years followed over period 12–30 months. Conclusions: practical, accessible effective non-invasive way caries teeth. Its application requires regular monitoring. resulting black spot diminished immediate potassium iodide but may affect its effectiveness.

Язык: Английский

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Knowledge, Practices, and Attitudes Towards Silver Diamine Fluoride Therapy Among Dentists and Students in Southeastern Spain

Dentistry Journal, Год журнала: 2025, Номер 13(1), С. 20 - 20

Опубликована: Янв. 2, 2025

Background/Objectives: The use of silver diamine fluoride (SDF) has increased in recent years for the management caries lesions children and adults. aim this study is to determine level knowledge attitude Spanish dentists (GDPs) final-year dental students (DSs) regarding SDF. Methods: A cross-sectional survey (questionnaire) was carried out aimed at (n = 43) registered 1050) autonomous community region Murcia (Spain). Results: response rates were GDPs 7.7% 81) DSs 84.5% 38). Only 20.98% GDP respondents reported having been trained on SDF versus 100% DSs. Significant differences observed between groups (p < 0.05). While 94.7% aware indications SDF, only 56.8% general it. Similarly, hypersensitivity treatment, 71.1% informed 40.7% dentists, paediatric patients, DS group 59.3% GDPs. In adult vary from GDPs’ (50%) DSs’ (25.9%) responses. About know advantages 50.6% Both showed reluctance esthetic zones, with greater acceptance non-esthetic areas practice, fewer (27.16%) (23.68%) had applied reflecting a gap implementation. Conclusions: Dental significantly higher knowledge, situation that evidences high education training curricular guides universities.

Язык: Английский

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Impact of Silver Diamine Fluoride on Resin Composite Bond Strength: An In Vitro Study with Various Adhesive Systems.

Heliyon, Год журнала: 2025, Номер 11(2), С. e41731 - e41731

Опубликована: Янв. 1, 2025

This in vitro study investigates the effects of Silver Diamine Fluoride (SDF) application on shear bond strength (SBS) resin composite to sound and demineralized human teeth using different adhesive systems. Eighty third molars were sectioned, mounted acrylic blocks, prepared expose a 2 mm thick dentin layer. The randomly divided into eight groups, each representing combination or dentin, SDF application, system used. Demineralization was achieved pH cycling process. applied designated followed by use either an etch-and-rinse self-etch system. Resin then applied, SBS measured universal testing machine. Data analyzed three-way ANOVA post-hoc tests identify significant differences. generally led decrease (p < 0.05). In higher compared OptiBond FL showed than Clearfil SE Bond across all although difference not statistically > group no between non-application can significantly reduce with effect being dependent type state dentin. Further vivo studies are needed validate these findings.

Язык: Английский

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Erken Çocukluk Çağı Çürüklerinin Tedavisinde Gümüş Diamin Florürün Yeri ve Etki Alanlarıyla İlgili Yapılan Çalışmaların Derlenmesi

Sağlık Bilimlerinde Değer, Год журнала: 2025, Номер 15(1), С. 136 - 142

Опубликована: Янв. 3, 2025

Diş çürüğü dünya genelinde en sık görülen halk sağlığı sorunlarından biridir. Çocuklarda oldukça yaygın olarak tiplerinden Erken Çoculuk Çağı Çürükleri (EÇÇ) bu dönemde kronik hastalıklardan biridir ve çocukların sadece ağız sağlığını olumsuz yönde etkilemekle kalmaz genel sağlık durumunu, beslenmesini, büyüme gelişimini, yaşam kalitesini sosyal hayatını etkileyebilmektedir. Yönetiminde tedavisinde kullanılmak üzere geçmişten günümüze çok çeşitli planlamalar yapılmış yeni materyaller geliştirilmiştir. çürüğünün durdurulmasında kullanılan florür içerikli ajanlara gümüşün eklenenerek etkinliğinin arttırılması düşünülmüş Gümüş Diamin Florür (GDF) solüsyonlar Uygulaması kolay, basit noninvaziv bir solüsyondur. Çürük dokusu üzerinde antibakteriyel remineralize edici olduğu, çürüğün ilerlemesini durduğu yapılan çalışmalarda gösterilmiştir. En önemli dezavantajının ise diş dokularında siyah renklenmeye neden olabilmesi bildirilmektedir. Hangi konsantrasyonun hangi uygulama protokolünün kullanılmasının daha iyi sonuçlar vereceğine dair çalışmaya ihtiyaç bulunmaktadır. Bu derlemenin amacı EÇÇ kullanımı gittikçe yaygınlaşan GDF solüsyonların etki alanları ile ilgili çalışmaların derlenmesidir.

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Synergistic effect of nanosilver fluoride with L-arginine on remineralization of early carious lesions

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 18, 2025

The synergistic effect of nanosilver fluoride (NSF) with L-arginine on early carious lesions was evaluated. NSF synthesized from chitosan, acetic acid, silver nitrate, sodium borohydride, and fluoride. + Arg by adding L-arginine. After demineralization the enamel slabs extracted molar, remineralization agents were applied randomly dividing them into five groups (n = 15): varnish (NaF), diamine (SDF), NSF, Arg, control. surface microhardness (SMH), effects using microcomputed tomography color changes a spectrophotometer measured before after pH cycling. SMH analyzed Kruskal–Wallis test Dunn's test. Remineralization effects, one-way analysis variance Duncan's test; p-value < 0.05 considered significant. recovered to similar levels in all (p > 0.05), except control group SDF showed higher than NaF 0.05). caused largest discoloration other no difference discoloration. could be an alternative given its ability remineralize caries without

Язык: Английский

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Novel applications and advancements of silver diamine fluoride and its impact on primary and permanent teeth and properties of various dental materials: A comprehensive review

Saudi Journal for Health Sciences, Год журнала: 2025, Номер 14(1), С. 1 - 10

Опубликована: Янв. 1, 2025

Newer dental materials are being explored and developed through scientific studies to overcome the limitations of existing ones also optimize treatment outcomes. In context caries management, application silver diamine fluoride (SDF) agent is painless does not need cavity removal or excavation. SDF use in prevention eventually improves quality life patients who show limited cooperative behavior have access care treatments, i.e., young pediatric patients. addition, several beneficial facets been unveiled by recent adults geriatric The current literature reveals many exploring various potential applications advancements its impact on teeth materials. However, there a lack comprehensive review summarizing highlighting relevant findings published Hence, aim present was summarize from evidence-based this extensively electronic databases. available presented narrative way under following appropriate headings. Various novel with addition potassium iodide glutathione primary permanent properties (glass ionomer cement, composite, adhesives) used for reported studies. Furthermore, as irrigating solution endodontic field highlighted

Язык: Английский

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Minimizing tooth discoloration caused by topical silver diamine fluoride application: a systematic review

Journal of Dentistry, Год журнала: 2024, Номер 150, С. 105353 - 105353

Опубликована: Сен. 14, 2024

Язык: Английский

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Laser fluorescence assessment of dental caries arrest with two silver fluoride agents in patients with special needs– a preliminary report

Lasers in Medical Science, Год журнала: 2024, Номер 39(1)

Опубликована: Апрель 1, 2024

Abstract Purpose While silver diamine fluoride has been used extensively for caries arrest and desensitising, (AgF) at neutral pH may also have value as a minimally invasive dental treatment. This study explored the effectiveness of two AgF products (AgF/KI AgF/SnF 2 ) when in adult patients with special needs (SN) who had high risk salivary gland hypofunction. Methods split-mouth clinical study, over appointments 3-months apart, compared impact single application AgF/KI (Riva Star Aqua, SDI) (Creighton Dental CSDS, Whiteley) on matched carious lesions same arch, by visual-tactile (cVT) assessment status laser fluorescence (LF, DIAGNOdent) evaluation bacterial load lesions, using repeated measures analysis. Results Twelve participants were recruited study. A total 56 teeth (28 pairs) included. Both gave significant decrease activity measured cVT ( P < 0.0001) LF = 0.0027). There no statistically differences between treatments, response rates improvements active 92% arm, 96% arm. was effect tooth type, lesion arch plaque metabolism area site level outcomes, nor there clustering sites patient Overall, superior to detecting that still progressed despite treatment Conclusion or predictability (over 90%) achieving SN risk. Clinical should use examination combined readings detect are progressing require additional treatments. Future studies compare these modalities SDF explore factors such time applications need applications. Trial registration The registered Australian Trials Registry (ACTRN12621001139864p) 23/08/2021.

Язык: Английский

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Antibacterial Effects of Silver Diamine Fluoride, Potassium Iodide and Nanosilver Fluoride on Dual-species Biofilm

Journal of Dentistry, Год журнала: 2024, Номер 147, С. 105097 - 105097

Опубликована: Май 27, 2024

Язык: Английский

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