Zeitschrift für Naturforschung C,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Abstract
Diabetes
mellitus
(DM)
is
a
disorder
which
raised
at
the
alarming
level
and
it
characterized
by
hyperglycemia
results
from
impaired
action
of
insulin,
production
insulin
or
both
these
simultaneously.
Consequently,
causes
problems
failure
different
body
organs
such
as
kidneys,
heart,
eyes,
nerve
system.
Since
this
disease
cannot
be
completely
cured
until
now,
we
aimed
to
design
series
enzymes
inhibitors
tested
them
for
DM
treatment.
In
series,
benzimidazole-based
thiazolidinone
bearing
chalcone
derivatives
completed
in
four
step
reaction
their
structures
were
confirmed
through
various
spectroscopic
techniques.
A
significant
efficacy
on
antidiabetic
was
observed,
with
IC
50
values
ranging
25.05
±
0.04
56.08
0.07
μM
α-amylase
22.07
0.02
53.06
α-glucosidase.
The
obtained
compared
those
standard
glimepiride
drug
(IC
=
18.05
µM
15.02
0
.03
α-glucosidase).
synthesized
compounds
showed
promising
potency.
Moreover,
molecular
docking
study
conducted
most
active
analogs
better
understand
interactions
sites
targeted
enzymes.
Future Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Дек. 13, 2024
Benzimidazole-triazole
conjugates
are
very
active
hotspot
for
design
and
synthesis
of
promising
anticancer
agents.
The
target
analogs
showed
potent
selective
cytotoxicity
over
different
cancer
cell
lines
breast
lung
ones.
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(10), С. 733 - 756
Опубликована: Апрель 17, 2024
Abstract:
In
recent
times,
many
research
groups
have
focused
their
attention
on
nitrogencontaining
heterocyclic
compounds
with
the
aim
of
gaining
a
deeper
understanding
biological
characteristics.
Among
them,
molecules
based
1,2,3-triazole
and
benzimidazole
exhibited
diverse
applications
are
present
in
drug
molecules.
The
purpose
this
review
is
to
describe
various
benzimidazole-1,2,3-triazole
hybrids
provide
comprehensive
evaluation
properties.
discussed
study
been
synthesized
through
Cu(I)-catalyzed
1,3-dipolar
cycloaddition
reaction
between
azides
alkynes,
utilizing
scaffold
as
linkage
two
connecting
groups.
synthesis
several
benzimidazole-1,2,3-
triazole
covered
review,
along
assessment
anticancer,
antiproliferative,
antitubercular,
antibacterial,
antidepressant,
other
activities.
Moreover,
our
opinion,
may
be
useful
for
development
medicinally
significant
Abstract
A
series
of
2-benzimidazolamine-acetamide
derivatives
were
synthesized
by
substitution
reaction
different
anilines
with
chloroacetyl
chloride
followed
the
2-aminobenzimidazole
formed
substituted
chloroacetamides.
The
structures
all
compounds
elucidated
various
spectral
techniques
and
evaluated
against
five
bacterial
strains.
Out
ten,
N-(2-fluorophenyl)-substituted
acetamide
displayed
better
minimum
inhibitory
concentration
(MIC).
Disk
diffusion
assay
combination
studies
also
performed
on
same
compound.
Molecular
docking
this
compound
E.
coli
methionine
aminopeptidase
(METAP)
effective
binding,
molecular
dynamics
simulation
further
suggested
a
stable
complex
formation.
Thus,
these
results
indicate
that
scaffolds
can
serve
as
model
for
developing
antibacterial
agents.
Zeitschrift für Naturforschung C,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Abstract
Diabetes
mellitus
(DM)
is
a
disorder
which
raised
at
the
alarming
level
and
it
characterized
by
hyperglycemia
results
from
impaired
action
of
insulin,
production
insulin
or
both
these
simultaneously.
Consequently,
causes
problems
failure
different
body
organs
such
as
kidneys,
heart,
eyes,
nerve
system.
Since
this
disease
cannot
be
completely
cured
until
now,
we
aimed
to
design
series
enzymes
inhibitors
tested
them
for
DM
treatment.
In
series,
benzimidazole-based
thiazolidinone
bearing
chalcone
derivatives
completed
in
four
step
reaction
their
structures
were
confirmed
through
various
spectroscopic
techniques.
A
significant
efficacy
on
antidiabetic
was
observed,
with
IC
50
values
ranging
25.05
±
0.04
56.08
0.07
μM
α-amylase
22.07
0.02
53.06
α-glucosidase.
The
obtained
compared
those
standard
glimepiride
drug
(IC
=
18.05
µM
15.02
0
.03
α-glucosidase).
synthesized
compounds
showed
promising
potency.
Moreover,
molecular
docking
study
conducted
most
active
analogs
better
understand
interactions
sites
targeted
enzymes.
