Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Сен. 17, 2024
Язык: Английский
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
2
Antibiotics, Год журнала: 2025, Номер 14(3), С. 253 - 253
Опубликована: Март 1, 2025
Background/Objectives: Antimicrobial resistance (AMR) poses a significant public health threat, leading to increased mortality. The World Health Organization has established priority list highlighting critical multidrug-resistant (MDR) pathogens that demand urgent research on antimicrobial treatments. Considering this and the fact new antibiotics are only sporadically approved, natural antibacterial agents have seen resurgence in interest as potential alternatives conventional chemotherapeutics. Natural antibacterials, derived from microorganisms, higher fungi, plants, animals, minerals, food sources, offer diverse mechanisms of action against MDR pathogens. Here, we present comprehensive summary including brief history their application key strategies for using microorganisms (microbiopredators, such bacteriophages), plant extracts essential oils, minerals (e.g., silver copper), well compounds animal origin, milk or even venoms. review also addresses role prebiotics, probiotics, peptides, novel formulations nanoparticles. these compounds, terpenoids, alkaloids, phenolic explored alongside challenges application, e.g., extraction, formulation, pharmacokinetics. Conclusions: Future should focus developing eco-friendly, sustainable validating safety efficacy through clinical trials. Clear regulatory frameworks integrating into practice. Despite challenges, sources transformative combating AMR promoting solutions.
Язык: Английский
Процитировано
2
Journal of Functional Foods, Год журнала: 2025, Номер 125, С. 106666 - 106666
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
1
Antibiotics, Год журнала: 2025, Номер 14(2), С. 138 - 138
Опубликована: Фев. 1, 2025
Background/Objectives: Drug-induced dysbiosis, particularly from antibiotics, has emerged as a significant contributor to chronic diseases by disrupting gut microbiota composition and function. Plant-derived secondary metabolites, such polysaccharides, polyphenols, alkaloids, saponins, show potential in mitigating antibiotic-induced dysbiosis. This review aims consolidate evidence preclinical studies on the therapeutic effects of metabolites restoring microbial balance, emphasizing their mechanisms efficacy. Methods: A narrative was conducted using PubMed, Scopus, Web Science. Studies were selected based specific inclusion criteria, focusing animal models treated with for The search terms included “gut microbiota”, “antibiotics”, “secondary metabolites”. Data extraction focused alterations, metabolite-specific effects, action. Relevant findings systematically analyzed summarized. Results: Secondary demonstrated diverse impact dysbiosis modulating composition, reducing inflammation, supporting host biological markers. Polysaccharides polyphenols restored Firmicutes/Bacteroidetes ratio, increased beneficial taxa Lactobacillus Bifidobacterium, suppressed pathogenic bacteria like Escherichia-Shigella. Metabolites triterpenoid saponins enhanced barrier integrity upregulating tight junction proteins, while alkaloids reduced inflammation proinflammatory cytokines (e.g., TNF-α, IL-1β). These also improved short-chain fatty acid production, which is crucial systemic health. While primary focus, other drug classes PPIs, metformin) require further investigation. Conclusions: promise managing improving Future research should explore applicability types drug-induced validate human enhance clinical relevance.
Язык: Английский
Процитировано
0
Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100760 - 100760
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Annals of the New York Academy of Sciences, Год журнала: 2025, Номер unknown
Опубликована: Май 5, 2025
Abstract The human gut microbiome is a complex ecosystem that plays vital role in maintaining health and contributing to the pathogenesis of various diseases. This review proposes transformative approach involves engineering artificial microbial consortia—precisely designed communities microorganisms—for personalized modulation targeted therapeutic interventions. By integrating synthetic biology, systems advanced culturing techniques, tailored consortia can be developed perform specific functions within gut, including production molecules, immune responses, competition against pathogenic bacteria. In vitro vivo studies indicate these engineered effectively restore balance enhance host resilience. holds immense potential revolutionize healthcare by addressing root causes diseases such as metabolic disorders, inflammatory conditions, gastrointestinal infections through precise manipulation microbiome. Future research should focus on rigorous clinical trials evaluate safety, efficacy, long‐term impacts diverse populations, paving way for innovative therapies promote overall well‐being.
Язык: Английский
Процитировано
0
Journal of Medicine and Life, Год журнала: 2024, Номер 17(10), С. 948 - 952
Опубликована: Окт. 1, 2024
The connection between the immune response and composition of gut microbiota has been associated with an increased prevalence atopic dermatitis in first year life. study aimed to investigate characteristics infants compared healthy better understand link early-life development dermatitis. analyzed intestinal 121 clinical signs dermatitis, divided into Group I (infants dermatitis) II (healthy controls). showed that presented values proteolytic bacteria mainly represented by Enterobacter species (P = 0.041), Klebsiella 0.038), Escherichia coli 0.013), significantly decreased levels acidifying Enterococcus species, Lactobacillus Bifidobacterium < 0.05) normal Clostridium Candida albicans, Mould fungi Geotrichum species. This highlights distinct differences providing insights dynamic ecosystem during early life for future personalized therapeutic strategies.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
0