Antimicrobial peptides: from discovery to developmental applications
Applied and Environmental Microbiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Antimicrobial
resistance
(AMR)
has
emerged
as
a
significant
crisis
in
global
health.
Due
to
their
advantageous
properties,
antimicrobial
peptides
(AMPs)
have
garnered
considerable
attention
potential
alternative
therapy
address
the
AMR
crisis.
These
might
disrupt
cell
membranes
or
walls
exhibit
activity,
modulate
immune
response
promote
recovery
from
diseases.
In
recent
years,
progress
been
made
research
of
AMPs,
alongside
emergence
new
challenges.
This
review
first
systematically
summarizes
and
critically
discusses
advancements
understanding
characteristics
current
landscapes
well
regulatory
mechanisms
action
practical
applications,
particularly
those
reported
approved
within
last
5
years.
Additionally,
principles,
paths
for
identification,
future
trends
AMPs
are
also
analyzed
following
discussion
advantages
disadvantages
comparison
conventional
antibiotics.
Unlike
prior
literature
this
field,
report
summarized
latest
major
discovery
methods
and,
more
importantly,
emphasized
applications
by
supporting
various
viewpoints
using
selected
examples
AMPs'
real-life
scenarios.
Besides,
some
emerging
hot
topics
including
derived
gut
microbiota
synergistic
effects
combating
AMR,
were
profiled.
All
these
indicate
originality
provide
valuable
references
AMP
discoveries
applications.
Язык: Английский
Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture
Nanomaterials,
Год журнала:
2024,
Номер
14(24), С. 2018 - 2018
Опубликована: Дек. 16, 2024
Nanoparticles
(NPs)
have
emerged
as
a
potent
choice
for
various
applications,
from
drug
delivery
to
agricultural
studies,
serving
an
alternative
and
promising
methodology
future
advancements.
They
been
widely
explored
in
systems,
demonstrating
immense
promise
high
efficiency
the
of
numerous
biomolecules
such
proteins
anticancer
agents,
either
solely
or
modified
with
other
compounds
enhance
their
capabilities.
In
addition,
utilization
NPs
extends
antimicrobial
where
they
are
used
develop
novel
antibacterial,
antifungal,
antiviral
formulations
advanced
characteristics.
Lactoferrin
(Lf)
is
glycoprotein
recognized
its
significant
multifunctional
properties,
antimicrobial,
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects.
Its
activity
has
broad
distribution
human
body,
Lf
receptors
present
multiple
regions.
Current
research
shows
that
utilized
NP
technology
surface
material,
encapsulated
biomolecule,
even
itself.
Due
abundance
regions,
can
be
employed
material
targeted
strategies,
particularly
crossing
BBB
targeting
specific
cancers.
Furthermore,
synthesized
structure,
positioning
it
strong
candidate
NP-related
applications.
this
article,
we
explore
highlighted
underexplored
areas
applications
research.
Язык: Английский