Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
Hypobaric
hypoxia
is
widely
recognized
as
a
prominent
risk
factor
for
high-altitude
cerebral
edema
(HACE),
which
contributes
to
the
exacerbation
of
multiple
pathological
mechanisms,
including
oxidative
stress,
mitochondrial
dysfunction,
disruption
blood−;brain
barrier
integrity,
neuroinflammation,
and
neuronal
apoptosis.
Among
these
abnormalities
in
oxygen
metabolism,
hypoxia,
play
pivotal
roles
pathophysiology
HACE.
In
this
review,
our
objective
enhance
comprehension
underlying
molecular
mechanisms
implicated
HACE
by
investigating
potential
involvement
metabolism.
Addressing
aberrations
metabolism
holds
promise
providing
innovative
therapeutic
strategies
managing
Redox Biology,
Год журнала:
2025,
Номер
81, С. 103546 - 103546
Опубликована: Март 1, 2025
High-altitude
exposure
has
been
associated
with
an
increased
risk
of
hyperuricemia
(HU)
and
gout,
though
the
underlying
mechanisms
remain
poorly
understood.
We
conducted
a
comprehensive
analysis
serum
metabolome
phenome
in
both
discovery
validation
cohorts
Han
Chinese
individuals
who
underwent
long-term
moderate-altitude
(∼12
months),
as
well
independent
cohort
consisting
local
Tibetans
residing
Nyingchi
(>5
years).
Beta-Alanine
intervention
was
applied
hypoxanthine
potassium
oxonate-induced
vitro
vivo
experiments.
Individuals
exposed
to
moderate
altitude
exhibited
elevated
urate
increase
overall
medium-chain
fatty
acids
(MCFAs),
coupled
decrease
amino
(AAs)
short-chain
(SCFAs).
Rmcorr
correlation
revealed
significant
negative
association
between
urate,
whereas
nonanoic
acid
versa,
potentially
driving
lower
residents.
Both
experiments
demonstrated
that
inhibited
xanthine
oxidase
(XOD)
reversed
HU
phenotype
human
hepatocytes
mice
induced
by
(HX)
oxonate
(PO),
urate-lowering
effect
mice.
Hepatic
pathology
transcriptome
treated
indicated
involved
inhibition
XOD,
amelioration
inflammation
hepatocytes,
promotion
renal
excretion.
Furthermore,
10-fold
cross-validation
random
forest
classification
(RFC)
predictive
modeling
based
on
selected
metabolites
phenotypes
achieved
area
under
receiver
operating
characteristic
(ROC)
curve
(AUC)
value
0.93
(95
%
confidence
interval
(CI):
0.85-1.00)
0.79
CI:
0.59-0.98)
for
distinguishing
high
asymptomatic
(AHU)
training
dataset
dataset,
respectively.
This
study
reveals
altered
could
ameliorate
hyperuricemia.
Our
findings
suggest
targeting
circulating
may
pave
novel
avenues
counter
diseases
HU.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Март 7, 2025
Introduction
High-altitude
environments
have
significant
effects
on
brain
function,
particularly
a
decline
in
cognitive
due
to
insufficient
oxygen
supply.
The
microbiome-gut-brain
axis
(MGBA)
plays
an
important
role
regulating
but
its
specific
mechanism
of
action
high-altitude
is
unclear.
Therefore,
the
aim
this
study
was
investigate
whether
probiotic
Lactobacillus
johnsonii
HL79
could
alleviate
high
altitude-induced
dysfunction
mice
by
modulating
gut
microbiota.
Methods
and
results
Sixty
C57BL/6
aged
8
weeks
were
randomly
divided
into
four
groups:
control,
altitude
exposure
(HA),
HL79-treated
(P),
plus
(HAP).
HA
HAP
groups
exposed
low-pressure
chamber
at
simulated
3,500–4,000
m
for
20
weeks,
while
Control
P
maintained
normal
barometric
pressure
level.
Probiotic
given
daily
gavage
groups,
saline
other
two
groups.
functions
assessed
new
object
recognition
test
elevated
maze
test.
showed
that
treatment
significantly
improved
working
memory
abilities
mice.
In
addition,
antioxidant
capacity,
decreased
malondialdehyde
(MDA)
content,
increased
superoxide
dismutase
(SOD)
catalase
(CAT)
activities
serum
whole
tissue.
Gut
microbiota
analysis
able
modulate
structure
increase
relative
abundance
beneficial
flora
environment.
Conclusion
ameliorated
altitude-exposed
further
confirming
MGBA
Frontiers in Physiology,
Год журнала:
2025,
Номер
16
Опубликована: Март 7, 2025
Acute
mountain
sickness
(AMS)
is
a
common
condition
following
rapid
exposure
to
high
altitude,
though
severe
complications
such
as
acute
gastrointestinal
bleeding,
systemic
inflammatory
response
syndrome
(SIRS)
and
multiple
organ
dysfunction
(MODS)
are
rare.
Herein,
we
report
case
of
SIRS
MODS
in
young
traveler
who
visited
Lhasa,
Tibet
(elevation
3,650
m).
Three
days
after
arrival,
the
patient
developed
headache,
abdominal
pain,
significant
hematemesis,
persistent
hypotension.
Gastroscopy
revealed
diffuse
bleeding
gastric
mucosa.
Laboratory
tests
indicated
multi-organ
involving
lungs,
liver,
kidneys.
The
responded
well
conservative
treatment
continuous
oxygen
supplementation.
This
represents
one
first
reported
instances
mucosal
injury
induced
by
AMS,
underscoring
medical
risks
associated
with
high-altitude
environments.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
Hypobaric
hypoxia
is
widely
recognized
as
a
prominent
risk
factor
for
high-altitude
cerebral
edema
(HACE),
which
contributes
to
the
exacerbation
of
multiple
pathological
mechanisms,
including
oxidative
stress,
mitochondrial
dysfunction,
disruption
blood−;brain
barrier
integrity,
neuroinflammation,
and
neuronal
apoptosis.
Among
these
abnormalities
in
oxygen
metabolism,
hypoxia,
play
pivotal
roles
pathophysiology
HACE.
In
this
review,
our
objective
enhance
comprehension
underlying
molecular
mechanisms
implicated
HACE
by
investigating
potential
involvement
metabolism.
Addressing
aberrations
metabolism
holds
promise
providing
innovative
therapeutic
strategies
managing
