Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 546 - 546
Опубликована: Фев. 21, 2023
Mounting
evidence
indicates
that
the
microbiota,
unique
combination
of
micro-organisms
residing
in
a
specific
environment,
plays
an
essential
role
development
wide
range
human
diseases,
including
skin
cancer.
Moreover,
persistent
imbalance
microbial
community,
named
dysbiosis,
can
also
be
associated
with
oxidative
stress,
well-known
emerging
force
involved
pathogenesis
several
cutaneous
malignancies.
Although
their
interplay
has
been
somewhat
suggested,
connection
between
and
cancer
is
largely
unexplored
field.
In
present
review,
we
discuss
current
knowledge
on
these
topics,
suggesting
potential
therapeutic
strategies.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 224 - 224
Опубликована: Фев. 7, 2025
Background/Objectives:
Voglibose,
an
α-glucosidase
inhibitor
commonly
prescribed
to
manage
postprandial
hyperglycemia
in
diabetes
mellitus,
demonstrates
potential
for
repurposing
as
anti-melanogenic
agent.
This
study
aims
explore
the
inhibitory
effects
of
voglibose
on
melanogenesis
and
elucidate
its
molecular
mechanisms,
highlighting
possible
applications
treating
hyperpigmentation
disorders.
Methods:
The
were
investigated
using
B16F10
melanoma
cells.
Cell
viability,
melanin
content,
tyrosinase
activity
assessed
following
treatment.
Western
blot
analysis
was
performed
examine
changes
melanogenic
proteins
transcription
factors.
role
signaling
pathways,
including
PKA/CREB,
MAPK,
PI3K/AKT,
GSK3β/β-Catenin,
analyzed.
Primary
human
skin
irritation
tests
conducted
evaluate
topical
safety
voglibose.
Results:
Voglibose
significantly
reduced
synthesis
cells
a
dose-dependent
manner.
revealed
decreased
expression
MITF,
TRP-1,
TRP-2,
indicating
inhibition
melanogenesis.
modulated
key
suppression
AKT
activation,
while
restoring
GSK3β
inhibit
β-catenin
stabilization.
Human
confirmed
voglibose’s
application,
showing
no
adverse
reactions
at
50
100
μM
concentrations.
Conclusions:
properties
through
modulation
multiple
pathways
biosynthesis.
Its
profile
efficacy
suggest
repurposed
drug
managing
advancing
cosmeceutical
applications.
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 236 - 236
Опубликована: Фев. 7, 2025
Nitrate
(NO3)
and
nitrite
(NO2)
are
important
nitrogen
compounds
that
play
a
vital
role
in
the
cycle,
contributing
to
plant
nutrition
broader
ecological
functions.
Nitrates
produced
from
nitric
acid
(HNO3),
while
nitrites
come
nitrous
(HNO2).
These
substances
commonly
found
environment,
especially
food
water,
due
contamination
both
human
natural
sources.
Human
activities
major
contributors
high
levels
of
nitrates
leading
environmental
pollution.
Although
is
crucial
for
growth,
excessive
fertilizer
use
has
caused
disruptions.
In
plants,
tend
accumulate
primarily
leaves
non-leguminous
crops,
such
as
leafy
vegetables,
which
known
their
nitrate
content.
Furthermore,
added
animal-based
foods,
processed
meats
cheeses,
prevent
bacterial
slow
spoilage,
improve
flavor
color.
The
concentration
these
can
vary
different
factors
like
farming
practices,
climate,
soil
conditions,
production
methods.
This
review
seeks
examine
differences
between
plant-based
sources
assess
potential
impact
on
health,
considering
also
paradigm
goes
beyond
oxide
production.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(1), С. 887 - 887
Опубликована: Янв. 3, 2023
Oxidative
stress
and
immune
response
play
an
important
role
in
the
development
of
several
cancers,
including
melanoma.
Ion
channels
are
aberrantly
expressed
tumour
cells
regulate
neoplastic
transformation,
malignant
progression,
resistance
to
therapy.
localized
plasma
membrane
or
other
cellular
membranes
targets
oxidative
stress,
which
is
particularly
elevated
At
same
time,
ion
crucial
for
normal
cancer
cell
physiology
subject
multiple
layers
regulation,
therefore
represent
promising
therapeutic
intervention.
In
this
review,
we
analyzed
effects
on
a
molecular
level
context
melanoma
progression
evasion.
The
possible
as
alternative
strategies
was
discussed.
Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 546 - 546
Опубликована: Фев. 21, 2023
Mounting
evidence
indicates
that
the
microbiota,
unique
combination
of
micro-organisms
residing
in
a
specific
environment,
plays
an
essential
role
development
wide
range
human
diseases,
including
skin
cancer.
Moreover,
persistent
imbalance
microbial
community,
named
dysbiosis,
can
also
be
associated
with
oxidative
stress,
well-known
emerging
force
involved
pathogenesis
several
cutaneous
malignancies.
Although
their
interplay
has
been
somewhat
suggested,
connection
between
and
cancer
is
largely
unexplored
field.
In
present
review,
we
discuss
current
knowledge
on
these
topics,
suggesting
potential
therapeutic
strategies.
