Drug and Chemical Toxicology,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Фев. 2, 2025
The
term
serotonin
syndrome
(SS)
is
a
potentially
life-threatening
devastating
condition
triggered
by
the
excessive
accumulation
of
serotonin,
often
due
to
an
overdose
or
concurrent
use
multiple
serotonergic
drugs.
Lavandula
angustifolia
(lavender),
known
plant
from
Lamiaceae
family,
very
rich
in
essential
oils,
minerals,
and
tannins.
This
study
aimed
elucidate
detrimental
effects
SS
on
brain
evaluate
neuroprotective
potential
L.
oil.
Male
rats
were
randomly
divided
into
following
groups:
control
(Group
1);
angustifolia-treated
2);
ondansetron-treated
high-dose
3);
sertraline-treated
4);
low-dose
ondansetron
+
5);
6);
sertraline
7);
8).
Neurotransmitter
levels,
dopamine
metabolites,
expressed
cytokines
quantified.
Additionally,
histological
assessment
hippocampus
was
performed.
results
revealed
significant
disruptions
neurotransmitter
amino
acid
levels
within
across
treated
groups.
Notably,
group
presented
pronounced
increases
5-HIAA,
proinflammatory
cytokines,
resulting
neurotoxicity
alterations
hippocampus.
Conversely,
treatment
with
significantly
attenuated
these
neurotoxic
effects.
findings
suggest
that
confers
neuroprotection
against
deleterious
SS,
particularly
counteracting
impact
combined
5-HT3
receptor
antagonists
reuptake
inhibitors
These
highlight
as
natural
therapeutic
agent
for
mitigating
SS-induced
neurotoxicity.
The
increasing
occurrence
of
chronic
metabolic
diseases
(CMDs)
presents
a
substantial
public
health
challenge
worldwide,
necessitating
the
development
pioneering
therapeutic
approaches.
Flavonoids,
which
are
naturally
occurring
compounds,
exert
broad
spectrum
biological
activities,
encompassing
their
anti-inflammatory,
anti-diabetic,
and
antioxidant
properties,
among
others.
Though
they
have
potential
role
in
treating
CMDs,
face
challenges
extraction
purification,
poor
gastrointestinal
absorption,
low
solubility,
rapid
metabolism,
impede
clinical
applicability.
Nanotherapeutics
has
been
receiving
significant
attention
as
it
aids
resolving
these
issues.
Hence,
purpose
this
chapter
is
to
shed
light
on
advances
different
nanoengineered
formulations
flavonoids.
commences
with
an
outline
diseases,
emphasizing
prevalence
pressing
need
for
innovative
therapeutics
strategies
address
burden.
Following
this,
flavonoids
conditions
discussed.
Moreover,
also
elucidates
nanoengineering
accomplishing
efficient
flavonoid
delivery,
particular
emphasis
versatile
nanoformulations,
such
liposomes,
solid
lipid
nanoparticles,
phytosomes.
Next,
we
discuss
optimization
techniques,
surface
modification
enhance
targeting
stability,
controlled
release
approaches
sustained
effects,
synergistic
outcomes.
enhancement
bioavailability
stability
addressed,
overcome
barriers,
targeted
delivery
site-specific
action,
methods
prevent
degradation.
Subsequent
sections
elucidate
managing
focusing
obesity,
diabetes,
cardiovascular
disorders.
mechanisms
action
impact
systems
efficacy
highlighted,
providing
valuable
insights.
It
highlights
involved
applicability
discusses
issues."
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 302 - 302
Опубликована: Янв. 16, 2025
Inflammation
and
oxidative
stress
are
the
main
pathogenetic
pathways
involved
in
development
of
several
chronic
degenerative
diseases.
Our
study
is
aimed
at
assessing
antioxidant
anti-inflammatory
activity
hydroalcoholic
extracts
obtained
from
wheat
its
derivatives.
The
content
total
phenolic
flavonoid
compounds
were
carried
out
by
ABTS
DPPH
assays.
ability
to
promote
microglia
polarization
towards
an
phenotype
was
evaluated
analyzing
increased
expression
markers
real-time
qPCR
immunofluorescence
Antioxidant
all
C.
elegans
ROS
levels
enzymes
GST-4
SOD-3
fluorescence
experiments.
key
genes
innate
immune
response
resistance
pathways-daf-16,
sek-1,
pmk-1-was
qPCR.
Wheat
showed
polarize
cells
phenotype,
even
after
addition
LPS.
An
detected
both
Caenorhabditis
nematode,
where
also
implemented
anti-stress
resilience
stimulated
immunity.
present
shows
that
seeds,
flour,
chaff,
pasta
as
well
activities
may
be
considered
prospective
positive
health
agents
for
preparation
functional
foods.
Moreover,
valorization
by-products
agricultural
agro-industrial
would
have
significant
implications
terms
circular
economy.
Drug and Chemical Toxicology,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Фев. 2, 2025
The
term
serotonin
syndrome
(SS)
is
a
potentially
life-threatening
devastating
condition
triggered
by
the
excessive
accumulation
of
serotonin,
often
due
to
an
overdose
or
concurrent
use
multiple
serotonergic
drugs.
Lavandula
angustifolia
(lavender),
known
plant
from
Lamiaceae
family,
very
rich
in
essential
oils,
minerals,
and
tannins.
This
study
aimed
elucidate
detrimental
effects
SS
on
brain
evaluate
neuroprotective
potential
L.
oil.
Male
rats
were
randomly
divided
into
following
groups:
control
(Group
1);
angustifolia-treated
2);
ondansetron-treated
high-dose
3);
sertraline-treated
4);
low-dose
ondansetron
+
5);
6);
sertraline
7);
8).
Neurotransmitter
levels,
dopamine
metabolites,
expressed
cytokines
quantified.
Additionally,
histological
assessment
hippocampus
was
performed.
results
revealed
significant
disruptions
neurotransmitter
amino
acid
levels
within
across
treated
groups.
Notably,
group
presented
pronounced
increases
5-HIAA,
proinflammatory
cytokines,
resulting
neurotoxicity
alterations
hippocampus.
Conversely,
treatment
with
significantly
attenuated
these
neurotoxic
effects.
findings
suggest
that
confers
neuroprotection
against
deleterious
SS,
particularly
counteracting
impact
combined
5-HT3
receptor
antagonists
reuptake
inhibitors
These
highlight
as
natural
therapeutic
agent
for
mitigating
SS-induced
neurotoxicity.
