New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117084 - 117084

Опубликована: Авг. 1, 2024

The accumulation of excess reactive oxygen species (ROS) can lead to oxidative stress (OS), which induce gene mutations, protein denaturation, and lipid peroxidation directly or indirectly. expression is reduced ATP level in cells, increased cytoplasmic Ca

Язык: Английский

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Senolytic therapeutics: An emerging treatment modality for osteoarthritis

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102275 - 102275

Опубликована: Март 15, 2024

Язык: Английский

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The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Cells, Год журнала: 2024, Номер 13(6), С. 550 - 550

Опубликована: Март 21, 2024

This review discusses the relationship between cellular senescence and radiation exposure. Given wide range of ionizing sources encountered by people in professional medical spheres, as well influence natural background radiation, question effect on biological processes, particularly aging remains highly relevant. The parallel radiation-induced reveals common aspects underlying these processes. Based recent scientific data, key points effects processes associated with aging, such genome instability, mitochondrial dysfunction, altered expression miRNAs, epigenetic profile, manifestation senescence-associated secretory phenotype (SASP), are discussed. Unraveling molecular mechanisms can make a valuable contribution to understanding genetic basis age-associated diseases context environmental

Язык: Английский

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Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production

Antioxidants, Год журнала: 2025, Номер 14(3), С. 259 - 259

Опубликована: Фев. 24, 2025

One of the major causes senescence is oxidative stress caused by ROS, which mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective approaches reduce them have not yet been developed. In this study, we screened secondary metabolites that plants produce under and discovered sauchinone as a potential candidate. Sauchinone induced function recovery, enabling efficient electron transport within chain (ETC). This led decrease in production, byproduct inefficient transport. The reduction rejuvenated senescence-associated phenotypes. To understand underlying mechanism rejuvenates carried out RNA sequencing found VAMP8 key gene. was downregulated sauchinone. Knockdown decreased levels subsequently function, similar effect Taken together, these studies revealed novel reduces regulating expression. Our results open new avenue aging research control production.

Язык: Английский

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Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer’s Disease Therapy

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10494 - 10494

Опубликована: Июнь 22, 2023

Liposomes modified with tetradecyltriphenylphosphonium bromide dual loading of α-tocopherol and donepezil hydrochloride were successfully designed for intranasal administration. Physicochemical characteristics cationic liposomes such as the hydrodynamic diameter, zeta potential, polydispersity index within range from 105 to 115 nm, +10 +23 mV, 0.1 0.2, respectively. In vitro release curves analyzed using Korsmeyer-Peppas, Higuchi, First-Order, Zero-Order kinetic models. Nanocontainers surfactant statistically better penetrate into mitochondria rat motoneurons. Imaging brain slices revealed penetration nanocarriers brain. Experiments on transgenic mice an Alzheimer's disease model (APP/PS1) demonstrated that administration 21 days resulted in enhanced learning abilities a reduction formation rate Aβ plaques entorhinal cortex hippocampus

Язык: Английский

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Integrative transcriptomics and proteomics analysis reveal the protection of Astragaloside IV against myocardial fibrosis by regulating senescence

European Journal of Pharmacology, Год журнала: 2024, Номер 975, С. 176632 - 176632

Опубликована: Май 6, 2024

Myocardial fibrosis (MF) is a pivotal pathological process implicated in various cardiovascular diseases, particularly heart failure. Astragaloside IV (AS-IV), natural compound derived from Astragalus membranaceus, possesses potent cardioprotective properties. However, the precise molecular mechanisms underlying its anti-MF effects, relation to senescence, remain elusive. Thus, this study aimed investigate therapeutic potential and of AS-IV treating ISO-induced MF mice, employing transcriptomics, proteomics, vitro, vivo experiments. We assessed positive effects on using HE staining, Masson ELISA, immunohistochemical transthoracic echocardiography, transmission electron microscopy, DHE fluorescence staining. Additionally, we elucidated regulatory role through comprehensive transcriptomics proteomics analyses, complemented by Western blotting RT-qPCR validation pertinent pathways. Our findings demonstrated that treatment markedly attenuated myocardial injury oxidative stress, concomitantly inhibiting release SASPs. Furthermore, integrated analyses revealed mechanism was associated with regulating cellular senescence p53 signaling pathway. These results highlight exerts not only stress but also modulating

Язык: Английский

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Mitochondria: fundamental characteristics, challenges, and impact on aging

Biogerontology, Год журнала: 2024, Номер 25(6), С. 923 - 941

Опубликована: Авг. 28, 2024

Язык: Английский

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Pickering emulsion stabilized by sugarcane leaf polyphenols-zein covalent nanoparticles for curcumin delivery: In-vitro and inhibition of oxidative hemolytic activity evaluation

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 687, С. 133539 - 133539

Опубликована: Фев. 24, 2024

Язык: Английский

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Knocking Down EGR1 Inhibits Nucleus Pulposus Cell Senescence and Mitochondrial Damage through Activation of PINK1-Parkin Dependent Mitophagy, Thereby Delaying Intervertebral Disc Degeneration

Free Radical Biology and Medicine, Год журнала: 2024, Номер 224, С. 9 - 22

Опубликована: Авг. 14, 2024

Язык: Английский

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Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient

Aging, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Aging | doi:10.18632/aging.206207. Yun Haeng Lee, Eun Young Jeong, Ye Hyang Kim, Ji Ho Park, Jee Hee Yoon, Yoo Jin So Hun Yeon Kyung Nam, Yoon Cha, Seong Youngjoo Byun, Song Seok Shin, Joon Tae Park

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