Experimental and Clinical Medicine,
Год журнала:
2023,
Номер
92(4)
Опубликована: Дек. 31, 2023
Understanding
the
age-related
changes
in
myocardial
blood
supply
under
conditions
of
diabetes
mellitus
and
stress
will
help
reveal
pathway
diabetic
cardiomyopathy,
considering
age
aspect.
Therefore,
aim
our
work
is
to
investigate
morpho-functional
hemomicrocirculatory
bed
(HMB)
myocardium
rats
with
experimental
streptozotocin-induced
(SDM)
chronic
immobilization
(CIS).
The
study
used
heart
fragments
from
56
2-month-old
6-month-old
male
white
rats,
which
were
divided
into
3
groups:
1
group
comorbid
pathology,
including
modeled
SDM
CIS,
2
SDM,
–
control
group.
material
was
collected
14th
56th
days
start
experiment.
According
findings,
hyperglycemia,
on
day
experiment
lead
spasm
arterioles
HMB
a
significant
deterioration
their
permeability,
as
evidenced
by
likely
increase
Vongenwort
index
arterioles.
On
days,
groups
vacuolar
dystrophy
coagulation
necrosis
endotheliocytes
myocytes,
focal
destruction
capillary
walls,
thickening,
proliferation
basement
membrane,
pronounced
micro-
macroclasmatic
changes,
capillarosclerosis
are
observed.
In
contrast,
alongside
destructive
vessels
show
phenomena
neovascularization.
Thus,
SCD
leads
development
microangiopathy
different
groups.
animals
damage
more
observation
manifested
by:
capillarosclerosis.
destructively
changed
capillaries,
we
found
former
new
characteristic
ultrastructure.
Keywords:
heart,
failure,
mellitus,
cardiovascular
diseases,
bed.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 692 - 692
Опубликована: Май 27, 2024
There
are
a
wide
variety
of
phytochemicals
collectively
known
as
polyphenols.
Their
structural
diversity
results
in
broad
range
characteristics
and
biological
effects.
Polyphenols
can
be
found
foods
drinks,
including
fruits,
cereals,
tea,
coffee.
Studies
both
vitro
vivo,
well
clinical
trials,
have
shown
that
they
possess
potent
antioxidant
activities,
numerous
therapeutic
effects,
health
advantages.
Dietary
polyphenols
demonstrated
the
potential
to
prevent
many
problems,
obesity,
atherosclerosis,
high
blood
sugar,
diabetes,
hypertension,
cancer,
neurological
diseases.
In
this
paper,
protective
effects
mechanisms
behind
them
investigated
detail,
citing
most
recent
available
literature.
This
review
aims
provide
comprehensive
overview
current
knowledge
on
role
preventing
managing
chronic
The
cited
publications
derived
from
vitro,
human-based
studies
trials.
A
more
complete
understanding
these
naturally
occurring
metabolites
will
pave
way
for
development
novel
polyphenol-rich
diet
drug
programs.
This,
turn,
provides
further
evidence
their
benefits.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115802 - 115802
Опубликована: Окт. 31, 2023
Diabetes
mellitus
is
a
metabolic
disease
caused
by
disorders
of
insulin
secretion
and
utilization.
Long-term
hyperglycemia,
resistance,
glucose
lipid
metabolism
cause
vascular
endothelial
cell
damage.
Endothelial
dysfunction
key
feature
diabetic
complications
such
as
nephropathy,
retinopathy,
neuropathy,
atherosclerosis.
Importantly,
death
thought
to
be
factor
contributing
injury.
Morphologically,
can
divided
into
three
forms:
type
I
apoptosis,
II
autophagy,
III
necrosis.
According
the
difference
in
function,
accidental
(ACD)
regulated
(RCD).
RCD
controlled
process
involving
numerous
proteins
precise
signaling
cascades.
Multiple
subroutines
covered
may
involved
dysfunction,
including
necroptosis,
pyroptosis,
entosis,
ferroptosis,
ferroautophagy,
parthanatos,
netotic
death,
lysosome-dependent
alkaliptosis,
oxeiptosis,
cuproptosis,
PANoptosis.
This
article
briefly
reviews
mechanism
significance
associated
with
which
will
help
deepen
understanding
provide
new
therapeutic
ideas.
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7209 - 7209
Опубликована: Окт. 21, 2023
The
clinical
relationship
between
diabetes
and
inflammation
is
well
established.
Evidence
clearly
indicates
that
disrupting
oxidant-antioxidant
equilibrium
elevated
lipid
peroxidation
could
be
a
potential
mechanism
for
chronic
kidney
disease
associated
with
type
2
mellitus
(T2DM).
Under
diabetic
conditions,
hyperglycemia,
especially
inflammation,
increased
reactive
oxygen
species
generation
are
bidirectionally
associated.
Inflammation,
oxidative
stress,
tissue
damage
believed
to
play
role
in
the
development
of
diabetes.
Although
exact
underlying
stress
its
impact
on
progression
remains
uncertain,
hyperglycemia-inflammation-oxidative
interaction
plays
significant
onset
vascular
disease,
hepatic
injury,
pancreas
and,
therefore,
holds
promise
as
therapeutic
target.
strongly
use
multiple
antidiabetic
medications
fails
achieve
normal
range
glycated
hemoglobin
targets,
signifying
treatment-resistant
Antioxidants
polyphenols
considered
useful
adjuvant
therapy
their
anti-inflammatory
effect
antioxidant
activity.
We
aimed
analyze
current
major
points
reported
preclinical,
vivo,
studies
antioxidants
prevention
or
treatment
T2DM.
Then,
we
will
share
our
speculative
vision
future
trials.
There
has
been
considerable
interest
in
gene
vectors
and
their
role
regulating
cellular
activities
treating
diseases
since
the
advent
of
nucleic
acid
drugs.
MicroRNA
(miR)
therapeutic
strategies
are
research
hotspots
as
they
regulate
expression
post-transcriptionally
treat
a
range
diseases.
An
original
tetrahedral
framework
(tFNA)
analog,
bioswitchable
miR
inhibitor
delivery
system
(BiRDS)
carrying
inhibitors,
is
previously
established;
however,
it
remains
unknown
whether
BiRDS
can
be
equipped
with
mimics.
Taking
advantage
transport
capacity
upgrading
further,
treatment
outcomes
traditional
tFNA
at
different
concentrations
on
TGF-β-
bleomycin-induced
fibrosis
simultaneously
vitro
vivo
compared.
upgraded
designed
by
successfully
synthesizing
novel
BiRDS,
mimic,
miR-27a,
for
skin
inhibiting
pyroptosis
pathway,
which
exhibits
stability
biocompatibility.
three
times
higher
efficiency
delivering
miRNAs
than
conventional
sticky
ends.
Moreover,
more
potent
against
pyroptosis-related
tFNAs.
These
findings
indicate
that
applied
drug
disease
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7130 - 7130
Опубликована: Июнь 28, 2024
Pyroptosis,
known
as
one
typical
mode
of
programmed
cell
death,
is
generally
characterized
by
the
cleaved
gasdermin
family
(GSDMs)
forming
pores
in
membrane
and
inducing
rupture,
activation
aspartate-specific
proteases
(caspases)
has
also
been
found
during
this
process.
Diabetic
Kidney
Disease
(DKD)
caused
complication
diabetes
kidney,
most
important
kidney’s
function,
Glomerular
Filtration
Rate
(GFR),
happens
to
drop
less
than
90%
its
usual
even
lead
kidney
failure
severe
cases.
The
persistent
inflammatory
state
induced
high
blood
glucose
implies
key
pathology
DKD,
growing
evidence
shows
that
pyroptosis
serves
a
significant
contributor
chronic
immune-mediated
disorder.
Currently,
expanded
discovery
GSDMs,
pyroptosis,
association
with
innate
immunity
more
attractive,
overwhelming
research
needed
sort
out
implication
DKD
pathology.
In
review,
we
comb
both
classical
studies
newly
founds
on
prick
off
novel
awakening
center
significance
treatment,
aiming
provide
new
targets
treatment
strategies
DKD.
