Experimental and Clinical Medicine,
Год журнала:
2023,
Номер
92(4)
Опубликована: Дек. 31, 2023
Understanding
the
age-related
changes
in
myocardial
blood
supply
under
conditions
of
diabetes
mellitus
and
stress
will
help
reveal
pathway
diabetic
cardiomyopathy,
considering
age
aspect.
Therefore,
aim
our
work
is
to
investigate
morpho-functional
hemomicrocirculatory
bed
(HMB)
myocardium
rats
with
experimental
streptozotocin-induced
(SDM)
chronic
immobilization
(CIS).
The
study
used
heart
fragments
from
56
2-month-old
6-month-old
male
white
rats,
which
were
divided
into
3
groups:
1
group
comorbid
pathology,
including
modeled
SDM
CIS,
2
SDM,
–
control
group.
material
was
collected
14th
56th
days
start
experiment.
According
findings,
hyperglycemia,
on
day
experiment
lead
spasm
arterioles
HMB
a
significant
deterioration
their
permeability,
as
evidenced
by
likely
increase
Vongenwort
index
arterioles.
On
days,
groups
vacuolar
dystrophy
coagulation
necrosis
endotheliocytes
myocytes,
focal
destruction
capillary
walls,
thickening,
proliferation
basement
membrane,
pronounced
micro-
macroclasmatic
changes,
capillarosclerosis
are
observed.
In
contrast,
alongside
destructive
vessels
show
phenomena
neovascularization.
Thus,
SCD
leads
development
microangiopathy
different
groups.
animals
damage
more
observation
manifested
by:
capillarosclerosis.
destructively
changed
capillaries,
we
found
former
new
characteristic
ultrastructure.
Keywords:
heart,
failure,
mellitus,
cardiovascular
diseases,
bed.
ACS Omega,
Год журнала:
2024,
Номер
9(16), С. 18296 - 18303
Опубликована: Апрель 12, 2024
Cyclophosphamide
(CPM)
is
a
well-established
antineoplastic
drug
with
marked
clinical
outcomes
in
various
types
of
cancers.
Despite
being
promising
drug,
its
use
associated
significant
renal
toxicity
and
often
limits
use,
leading
to
compromised
outcomes.
Therefore,
this
study
explored
the
protective
effect
bergapten
(BGP),
natural
bioactive
compound
that
showed
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects.
Till
now,
BGP
has
not
been
studied
for
an
vivo
model.
Animals
were
divided
into
control,
toxic,
BGP-3,
BGP-10,
Per
se.
The
control
group
was
treated
normal
saline
2
weeks.
To
toxic
group,
CPM
200
mg/kg
given
on
day
7
as
i.p.
10,
se,
BGP-3
10
mg/kg,
ip
weeks
single
shot
7.
se
only
from
1
14.
After
14
days,
animals
sacrificed,
kidneys
removed
markers
oxidative
stress,
inflammation,
injury,
fibrosis,
damage
using
biochemical,
histopathological,
immunohistochemical
studies.
We
found
BGP-10
effectively
reversed
toward
normal,
whereas
failed
exhibit
effect.
conclude
could
be
potential
hence,
more
detailed
cellular
molecular-based
studies
are
needed
bring
bench
bedside.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 116002 - 116002
Опубликована: Дек. 12, 2023
The
heart
undergoes
pathological
cardiac
hypertrophy
as
an
adaptive
response
to
prolonged
stimulation,
leading
cardiomyocyte
hypertrophy,
fibroblast
proliferation,
and
increase
in
extracellular
matrix.
Chinese
medicine
monomers
are
now
receiving
much
attention
for
the
treatment
of
myocardial
remodeling.
Biochanin
A
(BCA)
is
a
kind
flavonoid
structural
monomer,
which
has
certain
therapeutic
effect
on
bone
thinning
disease,
aging
syndrome,
lung
cancer,
etc.
Moreover,
it
exhibits
hypoglycemic,
anti-inflammatory,
anti-oxidation,
anti-bacteria
other
pharmacological
properties.
It
still
unknown
whether
BCA
impact
mechanism
TAC-induced
hypertrophy.
Here,
remodeling
was
induced
by
TAC.
injected
intraperitoneally
at
25
50
mg/kg/day
one
week
advance.
Masson,
WGA,
DHE
staining
serum
were
used
detect
inhibitory
mice.
anti-hypertrophic
demonstrated
studying
manifestations
Neonatal
rat
cardiomyocytes
(NRCMs)
fibroblasts
(CFs)
vitro.
results
showed
that
significantly
reduced
fibrosis,
inflammation,
oxidative
stress,
inhibited
Ang
II-induced
cell
stress
NRCMs
vitro
CF
migration,
collagen
secretion.
This
suggests
plays
key
role
inhibiting
progression
remodeling,
suggesting
may
be
promising
agent
fibrosis.
Jurnal Penelitian Pendidikan IPA,
Год журнала:
2024,
Номер
10(6), С. 2898 - 2905
Опубликована: Июнь 20, 2024
Diabetes
mellitus
is
a
chronic
metabolic
disorder
characterized
by
elevated
blood
glucose
levels
resulting
from
insulin
deficiency
or
resistance.
Streptozotocin,
potent
diabetogenic
agent,
commonly
employed
to
induce
experimental
diabetes
selectively
damaging
pancreatic
beta
cells,
in
and
hyperglycemia.
Elevated
Malondialdehyde
(MDA)
levels,
indicative
of
oxidative
stress
lipid
peroxidation,
are
closely
linked
diabetic
complications.
This
study
aimed
investigate
the
association
between
MDA
Streptozotocin-induced
rat
diabetes,
shedding
light
on
potential
therapeutic
strategies.
Spectrophotometric
analysis
was
utilized
quantify
tissues,
providing
insights
into
extent
damage.
The
results
revealed
significant
correlation
glucose,
highlighting
role
pathogenesis.
These
findings
underscore
importance
targeting
management
prevent
In
conclusion,
emphasizes
relevance
monitoring
as
biomarker
for
assessing
conditions
guiding
interventions.
The Indonesian Biomedical Journal,
Год журнала:
2024,
Номер
16(3), С. 208 - 17
Опубликована: Июнь 26, 2024
BACKGROUND:
Long-term
usage
of
lithium
carbonate
(Li2CO3)
as
treatment
bipolar
disorder
might
cause
nephrotoxicity.
Li2CO3-induced
nephrotoxicity
usually
treated
by
renal
dialysis,
which
is
quite
expensive.
Usage
natural
products
that
possess
anti-inflammatory
and
antioxidant
properties
biochanin
A
(BCA)
may
be
useful
against
Li2CO3
Therefore,
this
study
was
conducted
to
evaluate
nephrotoxic
effects
BCA
therapeutic
protective
it.METHODS:
Twenty-eight
rats
divided
into
4
groups:
negative
control
(NC),
Li2CO3,
+
therapeutic,
group.
Complete
blood
picture,
serum
kidney
function
tests
(urea,
creatinine,
cystatin
C)
tissue
homogenate
oxidative
stress
index
malonaldehyde
(MDA),
superoxide
dismutase
(SOD),
glutathione
S-transferase
(GST)
catalase
(CAT)
were
measured
using
enzyme
linked
immunosorbent
assay
(ELISA)
methods.
While,
histopathological
changes
evaluated
under
light
microscope.RESULTS:
administration
elicited
significant
in
hematological
parameters
hypochromic
anemia,
decreased
platelets
leukocytosis.
Serum
urea,
creatinine
C
elevated.
Renal
analysis
revealed
elevation
MDA
decline
GST,
CAT,
SOD
levels.
Kidney
histopathology
hemorrhage
between
tubules,
glomerular
capillaries
congestion,
Bowman’s
space
dilatation,
structural
alterations
tubules
cells
include
loss
brush
border,
deeply
stained
nuclei
elevated
size
number
cytoplasmic
vacuoles.
Therapeutic
groups
showed
amelioration
alteration,
functions,
markers
restoration
tissues.CONCLUSION:
has
both
possibly
through
the
reduction
stress.KEYWORDS:
A,
changes,
kidney,
salt,
stress,
effects,
American Journal of Reproductive Immunology,
Год журнала:
2024,
Номер
92(1)
Опубликована: Июль 1, 2024
ABSTRACT
Problem
Vulvovaginal
candidiasis
(VVC)
is
a
common
mucosal
fungal
infection,
and
Candida
albicans
the
main
causative
agent.
The
NLRP3
inflammasome
plays
an
important
role
in
VVC,
but
underlying
mechanism
unknown.
Method
of
Study
Vaginal
epithelial
cells
were
divided
into
three
groups:
control,
C.
strain
SC5314
(wild‐type,
WT),
WT+
Matt
Cooper
Compound
950
(MCC950,
specific
inhibitor).
After
human
vaginal
pretreated
with
1
µmol/L
MCC950
for
2
h,
(MOI
=
1)
was
cocultured
12
h.
cell
supernatants
collected,
LDH
detected,
IL‐1β
IL‐18
levels
determined
by
ELISA.
expression
pyroptosis‐related
proteins
NLRP3,
Caspase‐1
p20
GSDMD
measured
Western
blotting
analysis.
protein
N‐terminus
(GSDMD‐N)
detected
immunofluorescence.
Results
In
this
study,
we
showed
that
WT
induced
pyroptosis
cells,
as
indicated
proinflammatory
cytokine
upregulated
p20,
GSDMD‐N.
reversed
changes
these
cytokines
cells.
Conclusion
activated
to
induce
pyroptosis.
inhibited
inflammasome,
reduced
pyroptosis,
decreased
release
inflammatory
cytokines.
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1349 - 1349
Опубликована: Окт. 23, 2024
Obstructive
sleep
apnea
(OSA)
is
a
common
respiratory
disorder,
primarily
characterized
by
two
pathological
features:
chronic
intermittent
hypoxia
(CIH)
and
deprivation
(SD).
OSA
has
been
identified
as
risk
factor
for
numerous
diseases,
the
inflammatory
response
related
to
programmed
cell
necrosis
believed
play
significant
role
in
occurrence
progression
of
multisystem
damage
induced
OSA,
with
increasing
attention
being
paid
pyroptosis.
Recent
studies
have
indicated
that
can
elevate
oxidative
stress
levels
body,
activating
process
pyroptosis
within
different
tissues,
ultimately
accelerating
organ
dysfunction.
However,
molecular
mechanisms
remain
unclear.
Therefore,
this
review
focuses
on
four
major
systems
received
concentrated
existing
research
order
explore
promoting
renal
cardiovascular
neurocognitive
skin
diseases
patients.
Furthermore,
we
provide
comprehensive
overview
methods
inhibiting
at
levels,
goal
identifying
viable
targets
therapeutic
strategies
addressing
OSA-related
complications.
Experimental and Clinical Medicine,
Год журнала:
2023,
Номер
92(4)
Опубликована: Дек. 31, 2023
Understanding
the
age-related
changes
in
myocardial
blood
supply
under
conditions
of
diabetes
mellitus
and
stress
will
help
reveal
pathway
diabetic
cardiomyopathy,
considering
age
aspect.
Therefore,
aim
our
work
is
to
investigate
morpho-functional
hemomicrocirculatory
bed
(HMB)
myocardium
rats
with
experimental
streptozotocin-induced
(SDM)
chronic
immobilization
(CIS).
The
study
used
heart
fragments
from
56
2-month-old
6-month-old
male
white
rats,
which
were
divided
into
3
groups:
1
group
comorbid
pathology,
including
modeled
SDM
CIS,
2
SDM,
–
control
group.
material
was
collected
14th
56th
days
start
experiment.
According
findings,
hyperglycemia,
on
day
experiment
lead
spasm
arterioles
HMB
a
significant
deterioration
their
permeability,
as
evidenced
by
likely
increase
Vongenwort
index
arterioles.
On
days,
groups
vacuolar
dystrophy
coagulation
necrosis
endotheliocytes
myocytes,
focal
destruction
capillary
walls,
thickening,
proliferation
basement
membrane,
pronounced
micro-
macroclasmatic
changes,
capillarosclerosis
are
observed.
In
contrast,
alongside
destructive
vessels
show
phenomena
neovascularization.
Thus,
SCD
leads
development
microangiopathy
different
groups.
animals
damage
more
observation
manifested
by:
capillarosclerosis.
destructively
changed
capillaries,
we
found
former
new
characteristic
ultrastructure.
Keywords:
heart,
failure,
mellitus,
cardiovascular
diseases,
bed.
