Current Drug Therapy,
Год журнала:
2023,
Номер
19(6), С. 621 - 627
Опубликована: Авг. 18, 2023
Abstract:
Numerous
herbal-based
Ayurvedic
and
Chinese
medications
contain
a
variety
of
phytochemicals
that
may
have
neuroprotective
impact
help
treat
neurodegenerative
diseases.
The
natural
medicinal
drug
has
long
been
used
to
neural
signs
symptoms.
There
an
enormous
public
clinical
interest
in
the
use
Phytoconstituents
for
neuroprotection
or
prevention
illnesses.
Various
compounds,
isolated
from
exclusive
sources
with
multiple
objectives
seem
as
capacity
promising
class
therapeutics
remedy
illnesses
associated
neuro-related
issues.
It
is
vitally
important
identify
create
novel
therapeutic
strategies.
possibility
safe,
naturally
occurring
secondary
metabolites
characteristics
present
plants
other
products.
This
review
intends
take
closer
look
at
some
specific
elements
phytoactives
are
thought
be
significant
treatment
Biomolecules,
Год журнала:
2023,
Номер
13(11), С. 1598 - 1598
Опубликована: Окт. 31, 2023
Anthocyanins
are
a
type
of
flavonoids
that
give
plants
and
fruits
their
vibrant
colors.
They
known
for
potent
antioxidant
properties
have
been
linked
to
various
health
benefits.
Upon
consumption,
anthocyanins
quickly
absorbed
can
penetrate
the
blood-brain
barrier
(BBB).
Research
based
on
population
studies
suggests
including
anthocyanin-rich
sources
in
diet
lower
risk
neurodegenerative
diseases.
exhibit
neuroprotective
effects
could
potentially
alleviate
symptoms
associated
with
such
In
this
review,
we
compiled
discussed
large
body
evidence
supporting
role
anthocyanins.
Our
examination
encompasses
human
studies,
animal
models,
cell
cultures.
We
delve
into
connection
between
anthocyanin
bioactivities
mechanisms
underlying
neurodegeneration.
findings
highlight
how
anthocyanins'
antioxidant,
anti-inflammatory,
anti-apoptotic
contribute
effects.
These
particularly
relevant
key
signaling
pathways
implicated
development
Alzheimer's
Parkinson's
conclusion,
outcome
review
integrating
foods
diets
serve
as
therapeutic
approach
neurological
conditions,
identify
promising
avenues
further
exploration
area.
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1131 - 1131
Опубликована: Сен. 19, 2024
Vitis
vinifera
L.,
commonly
known
as
grapes,
is
one
of
the
most
widely
cultivated
crops
worldwide,
with
over
80%
used
for
wine
production.
However,
winemaking
process
generates
substantial
residues,
including
grape
pomace
(GP),
lees,
and
wastewater,
which
can
pose
significant
environmental
economic
challenges.
Among
these,
GP
stands
out
not
only
a
waste
product
but
also
rich
source
polyphenols—bioactive
compounds
recognized
antioxidant
anti-inflammatory
properties.
Recent
advancements
have
expanded
application
GP-derived
extracts,
particularly
in
health
food
industries,
due
to
their
potent
bioactive
This
review
provides
comprehensive
overview
valorization
GP,
focusing
on
its
phenolic
composition
therapeutic
potential.
It
evokes
innovative,
environmentally
friendly
extraction
techniques
integrated
methods
chemical
analysis
these
valuable
compounds.
Additionally,
benefits
polyphenols
are
explored,
recent
experimental
findings
examining
metabolism
highlighting
key
role
gut
microbiota
processes.
These
insights
contribute
deeper
understanding
biological
activity
extracts
underscore
growing
significance
high-added-value
product.
By
illustrating
how
by-products
be
transformed
into
natural
agents,
this
emphasizes
importance
sustainable
development
eco-friendly
management
practices,
significantly
contributing
advancement
circular
economy.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12488 - 12488
Опубликована: Авг. 6, 2023
Mitochondria,
far
beyond
their
prominent
role
as
cellular
powerhouses,
are
complex
organelles
active
central
metabolic
hubs
that
capable
of
integrating
and
controlling
several
signaling
pathways
essential
for
neurological
processes,
including
neurogenesis
neuroplasticity.
On
the
other
hand,
mitochondria
themselves
regulated
from
a
series
proteins
to
achieve
best
efficiency
in
producing
energy,
establishing
network
performing
own
de
novo
synthesis
or
clearance.
Dysfunctions
processes
control
mitochondrial
biogenesis,
dynamics
bioenergetics
increasingly
associated
with
impairment
brain
development
involved
wide
variety
neurodevelopmental
disorders.
Here,
we
review
recent
evidence
proving
emerging
master
regulators
bioenergetics,
highlighting
skills
neurodevelopment
cognition.
We
analyze,
mechanistic
point
view,
bioenergetic
dysfunction
causally
interrelated
origins
typical
genetic
intellectual
disability-related
disorders,
such
Down,
Rett
Fragile
X
syndromes.
Finally,
discuss
whether
can
become
therapeutic
targets
improve
function
holistic
perspective.
Heliyon,
Год журнала:
2024,
Номер
10(7), С. e28119 - e28119
Опубликована: Апрель 1, 2024
The
association
between
dietary
vitamin
B1
intake
and
cognitive
performance
in
the
noninstitutionalized
older
adult
population
of
United
States
remains
unclear.
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 601 - 601
Опубликована: Фев. 7, 2025
Recent
studies
have
highlighted
the
neuroprotective
effects
of
polyphenols,
particularly
their
role
in
enhancing
brain-derived
neurotrophic
factor
(BDNF)
and
cAMP
response
element-binding
protein
(CREB)
activity.
This
study
aimed
to
evaluate
relationship
between
BDNF
CREB
levels
cognitive
performance
individuals
undergoing
a
polyphenol-rich
dietary
intervention.
A
randomized,
crossover,
double-blind,
placebo-controlled
clinical
trial
was
conducted
with
92
participants.
The
intervention
involved
daily
intake
an
encapsulated
concentrate
fruit,
vegetable,
berry
juice
powders
(Juice
Plus+
Premium®)
over
two
16-week
periods,
separated
by
4-week
washout
phase.
Cognitive
function
assessed
using
Stroop
Test,
Trail
Making
Reynolds
Intellectual
Screening
Test
(RIST).
plasma
were
measured
ELISA.
product
significantly
improved
performance,
as
evidenced
higher
scores
RIST,
compared
placebo.
Additionally,
notably
elevated
condition,
indicating
enhanced
findings
suggest
that
nutraceuticals
can
modulate
neurobiological
mechanisms
underlying
improvements,
primarily
through
reduction
oxidative
stress
regulation
signaling
pathways
associated
synaptic
plasticity.
These
results
support
potential
polyphenols
promoting
health
preventing
neurodegenerative
diseases.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 344 - 344
Опубликована: Фев. 27, 2025
Age-related
oxidative
stress
is
a
critical
factor
in
vascular
dysfunction,
contributing
to
hypertension
and
atherosclerosis.
Smooth
muscle
cells
endothelial
are
particularly
susceptible
damage,
which
exacerbates
aging
through
cellular
senescence,
chronic
inflammation,
arterial
stiffness.
Gasotransmitters—hydrogen
sulfide
(H2S),
nitric
oxide
(NO),
carbon
monoxide
(CO)—are
emerging
as
promising
therapeutic
agents
for
counteracting
these
processes.
This
review
synthesizes
findings
from
recent
studies
focusing
on
the
mechanisms
by
H2S,
NO,
CO
influence
smooth
cell
function.
Therapeutic
strategies
involving
exogenous
gasotransmitter
delivery
systems
combination
therapies
were
analyzed.
H2S
enhances
mitochondrial
bioenergetics,
scavenges
ROS,
activates
antioxidant
pathways.
NO
improves
function,
promotes
vasodilation,
inhibits
platelet
aggregation.
exhibits
cytoprotective
anti-inflammatory
effects
modulating
heme
oxygenase
activity
ROS
production.
In
preclinical
studies,
gasotransmitter-releasing
molecules
(e.g.,
NaHS,
SNAP,
CORMs)
targeted
show
significant
promise.
Synergistic
with
lifestyle
modifications
further
enhance
their
potential.
conclusion,
gasotransmitters
hold
promise
combat
age-related
cells.
Their
multifaceted
innovative
approaches
make
them
potential
candidates
treating
dysfunction
promoting
healthy
aging.
Further
research
needed
translate
into
clinical
applications.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11223 - 11223
Опубликована: Окт. 18, 2024
As
the
global
population
ages,
incidence
of
neurodegenerative
diseases
such
as
Alzheimer’s
and
Parkinson’s
is
rapidly
rising.
These
present
a
significant
public
health
challenge,
they
severely
impair
cognitive
motor
functions,
ultimately
leading
to
substantial
reduction
in
quality
life
placing
heavy
burden
on
healthcare
systems
worldwide.
Although
several
therapeutic
agents
have
been
developed
manage
symptoms
these
diseases,
their
effectiveness
often
limited,
there
remains
an
urgent
need
for
preventive
strategies.
Growing
evidence
indicates
that
bioactive
compounds
from
natural
products
possess
neuroprotective
properties
through
antioxidant
anti-inflammatory
effects,
modulating
key
pathways
phosphatidylinositol
3-kinase/protein
kinase
B
(PI3K/AKT)
brain-derived
neurotrophic
factor–tropomyosin
receptor
B–cAMP
response
element-binding
protein
(BDNF-TrkB-CREB),
which
are
crucial
neuronal
survival.
may
also
reduce
amyloid-beta
tau
pathology,
well
enhance
cholinergic
neurotransmission
by
inhibiting
acetylcholinesterase
activity.
By
targeting
oxidative
stress,
neuroinflammation,
neurodegeneration,
offer
promising
approach
both
prevention
treatment.
findings
suggest
be
preventing
treating
diseases.
This
review
aims
explore
pathogenesis
limitations
current
therapies,
potential
role
agents.
