In
recent
years,
the
emergence
of
cancer
drug
resistance
is
one
crucial
tumor
hallmarks
which
supported
by
level
genetic
heterogeneity
and
complexities
at
cellular
levels.
Oxidative
stress,
immune
evasion,
metabolic
reprogramming,
overexpression
ABC
transporters
stemness
are
among
several
key
contributing
molecular
response
mechanisms.
Topo-active
drugs,
e.g.,
doxorubicin
topotecan,
clinically
active
utilized
extensively
against
a
wide
variety
human
tumors
often
results
in
development
failure
to
therapy.
Thus,
there
an
urgent
need
for
incremental
comprehensive
understanding
mechanisms
specifically
context
topo-active
drugs.
This
review
delves
into
intricate
mechanistic
aspects
these
intracellular
extracellular
explores
use
potential
combinatorial
approaches
utilizing
various
drugs
inhibitors
pathways
involved
resistance.
We
believe
that
this
will
help
guide
basic
scientists,
pre-clinicians,
clinicians,
policymakers
toward
holistic
interdisciplinary
strategies
transcend
resistance,
renewing
optimism
ongoing
battle
cancer.
PeerJ,
Год журнала:
2024,
Номер
12, С. e18708 - e18708
Опубликована: Дек. 19, 2024
Ferroptosis
is
a
novel
form
of
programmed
cell
death
characterized
by
iron
accumulation,
lipid
peroxidation,
and
decline
in
antioxidant
capacity,
all
which
are
regulated
gene
expression.
The
onset
numerous
diseases
closely
associated
with
ferroptosis.
Common
affect
large
population,
reduce
the
quality
life,
impose
an
increased
burden
on
healthcare
system.
role
ferroptosis
common
diseases,
its
therapeutic
potential,
even
translation
into
clinical
drug
treatments
currently
significant
research
topics
worldwide.
This
study
preliminarily
explores
theoretical
basis
ferroptosis,
mechanism
treatment
prospect
including
ischaemia-reperfusion
injury,
inflammatory
bowel
liver
fibrosis,
acute
kidney
diabetic
disease,
stroke,
Alzheimer’s
cardiovascular
immune
cancer.
review
provides
foundation
for
further
development
as
well
prevention
diseases.
In
recent
years,
the
emergence
of
cancer
drug
resistance
is
one
crucial
tumor
hallmarks
which
supported
by
level
genetic
heterogeneity
and
complexities
at
cellular
levels.
Oxidative
stress,
immune
evasion,
metabolic
reprogramming,
overexpression
ABC
transporters
stemness
are
among
several
key
contributing
molecular
response
mechanisms.
Topo-active
drugs,
e.g.,
doxorubicin
topotecan,
clinically
active
utilized
extensively
against
a
wide
variety
human
tumors
often
results
in
development
failure
to
therapy.
Thus,
there
an
urgent
need
for
incremental
comprehensive
understanding
mechanisms
specifically
context
topo-active
drugs.
This
review
delves
into
intricate
mechanistic
aspects
these
intracellular
extracellular
explores
use
potential
combinatorial
approaches
utilizing
various
drugs
inhibitors
pathways
involved
resistance.
We
believe
that
this
will
help
guide
basic
scientists,
pre-clinicians,
clinicians,
policymakers
toward
holistic
interdisciplinary
strategies
transcend
resistance,
renewing
optimism
ongoing
battle
cancer.
