Biomolecules,
Год журнала:
2024,
Номер
14(1), С. 124 - 124
Опубликована: Янв. 17, 2024
Organisms
are
often
subjected
to
conditions
that
promote
cellular
stress.
Cell
responses
stress
include
the
activation
of
pathways
defend
against
and
recover
from
stress,
or
initiation
programmed
cell
death
eliminate
damaged
cells.
One
processes
can
be
triggered
under
is
transcription
variation
in
number
copies
satellite
DNA
sequences
(satDNA),
which
involved
response
mechanisms.
Satellite
DNAs
highly
repetitive
tandem
sequences,
mainly
located
centromeric
pericentromeric
regions
eukaryotic
chromosomes,
where
they
form
constitutive
heterochromatin.
non-coding
RNAs
(satncRNAs)
important
regulators
processes,
their
deregulation
has
been
associated
with
disease.
Also,
these
transcripts
have
stress-response
mechanisms
varied
species.
This
review
intends
explore
role
satncRNAs
when
cells
adverse
conditions.
Studying
satDNA
various
deepening
our
understanding
how
could
a
key
factor
uncovering
facts
about
functions
sequences.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6242 - 6242
Опубликована: Июнь 5, 2024
Magnesium-based
biomaterials
hold
remarkable
promise
for
various
clinical
applications,
offering
advantages
such
as
reduced
stress-shielding
and
enhanced
bone
strengthening
vascular
remodeling
compared
to
traditional
materials.
However,
ensuring
the
quality
of
preclinical
research
is
crucial
development
these
implants.
To
achieve
implant
success,
an
understanding
cellular
responses
post-implantation,
proper
model
selection,
good
study
design
are
crucial.
There
several
challenges
reaching
a
safe
effective
translation
laboratory
findings
into
practice.
The
utilization
Mg-based
biomedical
devices
eliminates
need
biomaterial
removal
surgery
post-healing
mitigates
adverse
effects
associated
with
permanent
implantation.
high
corrosion
rate
implants
poses
unexpected
degradation,
structural
failure,
hydrogen
evolution,
alkalization,
cytotoxicity.
biocompatibility
degradability
materials
based
on
magnesium
have
been
studied
by
many
researchers
in
vitro;
however,
evaluations
addressing
impact
material
vivo
still
be
improved.
Several
animal
models,
including
rats,
rabbits,
dogs,
pigs,
explored
assess
potential
magnesium-based
Moreover,
strategies
alloying
coating
identified
enhance
degradation
transform
opportunities.
This
review
aims
explore
Mg
across
applications
within
(in
vitro)
vivo)
models.
Biomolecules,
Год журнала:
2024,
Номер
14(1), С. 124 - 124
Опубликована: Янв. 17, 2024
Organisms
are
often
subjected
to
conditions
that
promote
cellular
stress.
Cell
responses
stress
include
the
activation
of
pathways
defend
against
and
recover
from
stress,
or
initiation
programmed
cell
death
eliminate
damaged
cells.
One
processes
can
be
triggered
under
is
transcription
variation
in
number
copies
satellite
DNA
sequences
(satDNA),
which
involved
response
mechanisms.
Satellite
DNAs
highly
repetitive
tandem
sequences,
mainly
located
centromeric
pericentromeric
regions
eukaryotic
chromosomes,
where
they
form
constitutive
heterochromatin.
non-coding
RNAs
(satncRNAs)
important
regulators
processes,
their
deregulation
has
been
associated
with
disease.
Also,
these
transcripts
have
stress-response
mechanisms
varied
species.
This
review
intends
explore
role
satncRNAs
when
cells
adverse
conditions.
Studying
satDNA
various
deepening
our
understanding
how
could
a
key
factor
uncovering
facts
about
functions
sequences.
