Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(20), С. 6068 - 6068
Опубликована: Окт. 11, 2024
:
The
multifactorial
nature
of
atherosclerotic
cardiovascular
disease
(ASCVD)
implicates
genetic,
environmental,
and
dietary
habits.
Antioxidants
found
in
foods
have
garnered
attention
for
their
potential
role
mitigating
ASCVD
risk
by
combating
oxidative
stress.
This
study
seeks
to
confirm
the
findings
previous
research
through
a
large-scale
cross-sectional
analysis
performed
unique
population
with
Korea
National
Health
Nutrition
Examination
Survey
data
explore
association
between
composite
antioxidant
index
(CDAI)
prevalence
among
middle-
old-aged
individuals
South
Korea.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 11, 2023
ABSTRACT
Pathogenic
brain
aging
and
neurodegenerative
diseases
such
as
Alzheimer’s
disease
Parkinson’s
are
characterized
by
chronic
neuroinflammation
the
accumulation
of
dysfunctional
or
misfolded
proteins
that
lead
to
progressive
neuronal
cell
death.
Here
we
demonstrate
a
murine
model
with
global
loss
CUL4-DDB1
substrate
receptor
WDR23
(
Wdr23KO
)
results
in
changes
multiple
age-related
hippocampal-dependent
behaviors.
The
behavioral
differences
observed
animals
accompany
stabilization
NRF2/NFE2L2
protein,
an
increase
RNA
transcripts
regulated
this
cytoprotective
transcription
factor,
steady
state
level
antioxidant
defense
proteins.
Taken
together,
these
findings
reveal
role
for
WDR23-proteostasis
mediating
capacity
hippocampus
potential
targeting
WDR23-NRF2
signaling
interactions
development
therapies
disorders.
HIGHLIGHTS
regulates
stability
mouse
Loss
Wdr23
significantly
increases
expression
NFE2L2/NRF2
target
genes
Global
influences
behaviors
differentially
males
females
Nutrients,
Год журнала:
2024,
Номер
16(7), С. 946 - 946
Опубликована: Март 26, 2024
Recently,
we
reported
that
during
the
hypertrophic
phase
(230
days
old)
of
hereditary
cardiomyopathy
hamster
(HCMH),
short-term
treatment
(20
days)
with
250
mg/kg/day
taurine
prevents
development
hypertrophy
in
males
but
not
females.
However,
mortality
rate
non-treated
animals
was
higher
females
than
males.
To
verify
whether
sex-dependency
effect
is
due
to
difference
disease’s
progression,
treated
230-day-old
for
a
longer
time
period
122
days.
Our
results
showed
long-term
low
and
high
concentrations
significantly
cardiac
early
death
HCMH
(p
<
0.0001
p
0.05,
respectively)
0.01
0.0001,
respectively).
demonstrate
sex
dependency
treatments
degree
heart
remodeling
when
compared
dependency.
In
addition,
studies
should
consider
differences
between
male
female
progression
disease.
Thus,
therapies
are
recommended
prevent
cardiomyopathy.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 28, 2024
The
landscape
of
sex
differences
in
Colorectal
Cancer
(CRC)
has
not
been
well
characterized
with
respect
to
the
mechanisms
action
for
oncogenes
such
as
KRAS.
However,
our
recent
study
showed
that
tumors
from
male
patients
KRAS
mutations
have
decreased
iron-dependent
cell
death
called
ferroptosis.
Building
on
these
findings,
we
further
examined
ferroptosis
CRC,
considering
both
patient
and
mutations,
using
public
databases
in-house
CRC
tumor
cohort.
Through
subsampling
inference
variable
importance
analysis
(VIMP),
identified
significant
gene
expression
between
mutant
wild
type
patients.
These
genes
suppress
(e.g.,
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(20), С. 6068 - 6068
Опубликована: Окт. 11, 2024
:
The
multifactorial
nature
of
atherosclerotic
cardiovascular
disease
(ASCVD)
implicates
genetic,
environmental,
and
dietary
habits.
Antioxidants
found
in
foods
have
garnered
attention
for
their
potential
role
mitigating
ASCVD
risk
by
combating
oxidative
stress.
This
study
seeks
to
confirm
the
findings
previous
research
through
a
large-scale
cross-sectional
analysis
performed
unique
population
with
Korea
National
Health
Nutrition
Examination
Survey
data
explore
association
between
composite
antioxidant
index
(CDAI)
prevalence
among
middle-
old-aged
individuals
South
Korea.
