Variations to plasma H2O2 levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology DOI Creative Commons
Haidong Yang,

Wenxi Sun,

Man Yang

и другие.

Schizophrenia, Год журнала: 2024, Номер 10(1)

Опубликована: Апрель 11, 2024

Abstract Accumulating evidence suggests that imbalanced oxidative stress (OS) may contribute to the mechanism of schizophrenia. The aim present study was evaluate associations OS parameters with psychopathological symptoms in male chronically medicated schizophrenia (CMS) and treatment-resistant (TRS) patients. Levels hydrogen peroxide (H 2 O ), hydroxyl radical (·OH), peroxidase (POD), α-tocopherol (α-toc), total antioxidant capacity (TAC), matrix metalloproteinase-9 (MMP-9), tissue inhibitor metalloproteinases-1 (TIMP-1) were assayed males CMS TRS, matched healthy controls. Schizophrenia assessed using Positive Negative Syndrome Scale (PANSS). results demonstrated significant differences variables H ( F = 5.068, p 0.008), ·OH 31.856, < 0.001), POD 14.043, α-toc 3.711, 0.027), TAC 24.098, MMP-9 3.219, 0.043) between TRS patients For patients, levels correlated PANSS positive subscale r 0.386, 0.032) smoking −0,412, 0.021), while significantly negatively score −0.578, 0.001) positively body mass index 0.412 0.357, 0.021 0.049, respectively). CMS, general 0.308, 0.031) −0.543, 0.001). Furthermore, , α-toc, be protective factors against a risk factor. Patients exhibit an imbalance OS, thus warranting future investigations.

Язык: Английский

Pesticide Exposure and Its Association with Parkinson’s Disease: A Case–Control Analysis DOI Creative Commons
Ali Samareh, Hossein Pourghadamyari, Mohammad Hadi Nematollahi

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 44(1)

Опубликована: Ноя. 1, 2024

Parkinson's disease (PD) is a complex disorder that arises from genetic and environmental factors. The current investigation endeavors to investigate the role of exposure organochlorine (OCPs) organophosphate pesticides (OPPs), recognized as main elements, in genesis PD. In this case-control study, 29 PD patients 51 healthy subjects were involved. Gas chromatography was performed measure serum levels chemicals (2,4-DDT, 4,4-DDT, 2,4-DDE, 4,4-DDE, α-HCH, β-HCH, γ-HCH). Furthermore, acetylcholinesterase (AChE) activity, arylesterase activity paraoxonase-1 (PON-1), several oxidative stress (OS) markers assessed. OCPs significantly higher than control subjects. addition, AChE PON-1, catalase superoxide dismutase 3 less controls. However, carbonyl protein, total antioxidant capacity, malondialdehyde, nitric oxide findings have indicated OPPs could contribute development disease. This potential linkage either be established through direct impact these on nervous system, leading neurotoxicity, or via an indirect route triggering OS.

Язык: Английский

Процитировано

3
Effect of Group Cognitive Behavioral Therapy on Patients with Early-Onset Schizophrenia DOI
Jing Hu,

Bojing Geng,

Yu Song

и другие.

ALPHA PSYCHIATRY, Год журнала: 2024, Номер 25(3), С. 407 - 412

Опубликована: Авг. 2, 2024

To study the clinical effect of group cognitive behavioral therapy to one-on-one treatment on patients with early-onset schizophrenia. Totally,133 schizophrenia admitted Department Psychiatry our hospital from September 2020 2023 were selected and divided into a control an observation according whether was performed. The general demographic data collected, propensity score matching method used balance baseline 2 groups. Positive negative syndrome scale, Personal Social Performance Scale, severity illness (SI), efficacy index (EI) compared between groups after matching. After matching, 72 included in study. Compared group, PANSS decreased including intervention (P > .05). Both showed decrease before treatments. Negative Syndrome Scale reduction rate total response increased <.001). Clinical Global Impression (CGI) scores higher than those group. In CGI scores, there is significant difference that SI lower = .002), while EI Group beneficial improvement mental symptoms disease severity, social function, curative effect, which advocated popularized.

Язык: Английский

Процитировано

2
The Impact of Pesticides on Parkinson's Disease; A Case-Control Study DOI Creative Commons
Ali Samareh, Hossein Pourghadamyari,

Mohammad Hadi Nemtollahi

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

Abstract Background Parkinson's disease (PD) is a complex disorder that arises from genetic and environmental factors. The current investigation endeavors to investigate the role of exposure organochlorines (OCPs) organophosphate pesticides (OPPs), recognized as main elements, in genesis PD. Methods In this case-control study, 29 PD patients 51 healthy subjects (controls) were involved. Gas chromatography (GC) was performed measure serum levels organochlorine chemicals (2,4-DDT, 4,4-DDT, 2,4-DDE, 4,4-DDE, α-HCH, β-HCH, γ-HCH). Furthermore, acetylcholinesterase (AChE) activity, arylesterase activity paraoxonase-1 (PON-1), several oxidative stress (OS) markers assessed. Results OCPs significantly higher than control subjects. addition, AChE PON-1, catalase (CAT) superoxide dismutase 3 (SOD3) less controls. Although carbonyl protein (CP), total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO) Conclusion findings have indicated OPPs could contribute development disease. This potential linkage either be established through direct impact these on nervous system, leading neurotoxicity, or via an indirect route triggering OS.

Язык: Английский

Процитировано

1
Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia DOI Creative Commons
Dan Li, Yuanyuan Huang,

Hongxin Lu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 4, 2024

Abstract Objective Cognitive dysfunction is a prevalent and intricate manifestation of schizophrenia (SCZ) that may be associated with distinct clinical factors the presence antioxidants, which relationship unclear. The study aimed to investigate cognitive function its influencing in Chinese patients SCZ. Methods A group 133 SCZ 120 healthy controls (HCs) were recruited. MATRICS Consensus Battery (MCCB) was utilized evaluate ability, Positive Negative Syndrome Scale (PANSS) used assess symptoms. Levels plasma superoxide dismutase (SOD), serum albumin (ALB) uric acid (UA) assessed. Results Compared HCs, exhibited lower performance as indicated by MCCB scores, including dimensions speed processing, attention/vigilance, working memory, verbal learning, visual learning. In group, total PANSS scores negatively all (all p < 0.05), except for attention/vigilance score. PANSS-negative PANSS-cognitive subscores learning 0.05). PANSS-excited showed negative correlation memory ALB levels significantly decreased, their UA SOD notably elevated compared HCs correlated dimensions. independent contributors dimension. Conclusions decreased degree impairment closely related ALB,

Язык: Английский

Процитировано

0
Novel insight into the feed conversion ratio in laying hens and construction of its prediction model DOI Creative Commons
Yan Li,

Ruiyu Ma,

Renrong Qi

и другие.

Poultry Science, Год журнала: 2024, Номер 103(10), С. 104013 - 104013

Опубликована: Июль 5, 2024

Feed efficiency (FE) is an important economic factor in poultry production, and feed conversion ratio (FCR) one of the most widely used measures FE. Factors associated with FCR include genetics, environment, other factors. However, mechanisms responsible for chickens are still less well appreciated. In this study, we examined pattern changes FCR, then delved into understanding behind these variations from both genetic environmental perspectives. Most interestingly, at front section henhouse exhibited lowest value. Further investigation revealed that laying rate high (HFCR) group was lower than low (LFCR) (P < 0.05). Cortisol, total antioxidant capacity (TAOC), IgG levels LFCR were significantly those HFCR 0.05), while BUN level higher We identified a 67 10 differentially expressed genes (DEGs) ovarian small intestine tissues, respectively. Functional enrichment analysis DEGs they might affect by modulating salivary secretion, ferroptosis, mineral absorption. Moreover, values relative humidity (RH), air velocity (AV), PM

Язык: Английский

Процитировано

0
Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia DOI Creative Commons
Dan Li, Yuanyuan Huang,

Hongxin Lu

и другие.

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 18, 2024

Abstract Objective Cognitive dysfunction is a prevalent and intricate manifestation of schizophrenia (SCZ) that may be associated with distinct clinical factors the presence antioxidants, which relationship unclear. The study aimed to investigate cognitive function its influencing in Chinese patients SCZ. Methods A group 133 SCZ 120 healthy controls (HCs) were recruited. MATRICS Consensus Battery (MCCB) was utilized evaluate ability, Positive Negative Syndrome Scale (PANSS) used assess symptoms. Levels plasma superoxide dismutase (SOD), serum albumin (ALB) uric acid (UA) assessed. Results Compared HCs, exhibited lower performance as indicated by MCCB scores, including dimensions speed processing, attention/vigilance, working memory, verbal learning, visual learning. In group, total PANSS scores negatively all (all p < 0.05), except for attention/vigilance score. PANSS-negative PANSS-cognitive subscores learning 0.05). PANSS-excited showed negative correlation memory ALB levels significantly decreased, their UA SOD notably elevated compared HCs correlated dimensions. independent contributors dimension. Conclusion decreased degree impairment closely related ALB,

Язык: Английский

Процитировано

0
Variations to plasma H2O2 levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology DOI Creative Commons
Haidong Yang,

Wenxi Sun,

Man Yang

и другие.

Schizophrenia, Год журнала: 2024, Номер 10(1)

Опубликована: Апрель 11, 2024

Abstract Accumulating evidence suggests that imbalanced oxidative stress (OS) may contribute to the mechanism of schizophrenia. The aim present study was evaluate associations OS parameters with psychopathological symptoms in male chronically medicated schizophrenia (CMS) and treatment-resistant (TRS) patients. Levels hydrogen peroxide (H 2 O ), hydroxyl radical (·OH), peroxidase (POD), α-tocopherol (α-toc), total antioxidant capacity (TAC), matrix metalloproteinase-9 (MMP-9), tissue inhibitor metalloproteinases-1 (TIMP-1) were assayed males CMS TRS, matched healthy controls. Schizophrenia assessed using Positive Negative Syndrome Scale (PANSS). results demonstrated significant differences variables H ( F = 5.068, p 0.008), ·OH 31.856, < 0.001), POD 14.043, α-toc 3.711, 0.027), TAC 24.098, MMP-9 3.219, 0.043) between TRS patients For patients, levels correlated PANSS positive subscale r 0.386, 0.032) smoking −0,412, 0.021), while significantly negatively score −0.578, 0.001) positively body mass index 0.412 0.357, 0.021 0.049, respectively). CMS, general 0.308, 0.031) −0.543, 0.001). Furthermore, , α-toc, be protective factors against a risk factor. Patients exhibit an imbalance OS, thus warranting future investigations.

Язык: Английский

Процитировано

0