Effect of carbon source and elicitors on biomass production and accumulation of friedelin and epifriedelanol in hairy roots of hemp (Cannabis sativa L.)

Plant Cell Tissue and Organ Culture (PCTOC), Год журнала: 2024, Номер 156(2)

Опубликована: Янв. 22, 2024

Язык: Английский

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Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12738 - 12738

Опубликована: Ноя. 27, 2024

Cannabis sativa L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids cannabinoids, particularly Δ-9-tetrahydrocannabinol (THC) cannabidiol (CBD). Cannabinoids have an effect on endocannabinoid system (ECS), a cellular communication network, are, hence, widely studied for medical applications. Epidiolex®, 99% pure oral CBD extract, has been approved by FDA treatment of epilepsy. Nabiximols (Sativex) is oromucosal spray containing equal volume THC CBD, it commonly used as add-on unresponsive spasticity in multiple sclerosis (MS) patients. Several vitro vivo studies also shown that cannabinoids can be to treat various types cancer, such melanoma brain glioblastoma; first positive clinical trials anticancer THC:CBD blend temozolomide (TMZ) highly invasive cancer are very promising. The exert their properties investigations induction cell death, mainly apoptosis cytotoxic autophagy, inhibition proliferation. In several studies, found induce tumor regression inhibit angiogenic mechanisms vivo, well two low-numbered epidemiological studies. They exhibit antiviral effects inhibiting ACE2 transcription, blocking viral replication fusion, acting agents; indeed, prior consumption (a study 93,565 persons Chicago) associated much lower incidence SARS-CoV-2 infections. It postulated cannabis extracts many other diseases systemic lupus erythematosus, type 1 diabetes, or neurological disorders, e.g., Alzheimer’s disease. aim this review outline current state knowledge regarding currently medicinal preparations derived from C. selected diseases, present latest research potential applications its secondary metabolites.

Язык: Английский

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Hemp (<i>Cannabis sativa</i> L.) seeds nutritional aspects and food production perspectives: A review

Food systems, Год журнала: 2024, Номер 7(1), С. 52 - 58

Опубликована: Апрель 18, 2024

This review is devoted to an analysis of the hemp ( Cannabis sativa L.) seeds’ nutritional aspects and food production perspectives, that can become a valuable source multifunctional components for functional production. L. multipurpose crop with lowenvironmental impact traditionally cultivated in Western cultures fiber The propagation synthetic fibers intoxicating drugs from certain narcotic strains resulted banning its cultivation. Thus, culturing varieties are widely known as „industrial hemp“ has only been practiced past two decades. Hemp grown not economic importance but also value. seeds consists 25–35% lipids perfectly balanced fatty acids (FAs); 20–25% proteins, which easy digest contain all essential amino acids; 20–30% carbohydrates, mainly dietary fiber; vitamins minerals. Besides value, hempseed rich antioxidants bioactive compounds such peptides, polyphenols high free radicals scavenging activity, cannabinoids. Therefore, this study reviews scientific knowledge about their progressive cultivation, therapeutic potential, use

Язык: Английский

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Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems

Antibiotics, Год журнала: 2024, Номер 13(4), С. 369 - 369

Опубликована: Апрель 17, 2024

The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, synergy their aim this study was assess activity Henola Cannabis sativae extract its combinations with selected carriers (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer, magnesium aluminometasilicate, hydroxypropyl-β-cyclodextrin) terms antimicrobial, probiotic, immunobiological effects. As a result conducted research, antimicrobial confirmed relation following microorganisms: Clostridium difficile, Listeria monocytogenes, Enterococcus faecalis, Staphylococcus aureus, pyrogenes, Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, Pseudomonas aereuginosa, Candida albicans (microorganism count reduced from ~102 CFU mL−1 <10 most cases). Additionally, for system hydroxypropyl-β-cyclodextrin, significant probiotic potential against bacterial strains established Lactobacillus acidophilus, casei, plantarum, brevis, rhamnosus, reuteri, Pediococcus pentosaceus, Lactococcus lactis, fermentum, Streptococcus thermophilus increased 104–107). In immunomodulatory properties, it determined that tested systems caused changes IL-6, IL-8, TNF-α levels.

Язык: Английский

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3D Printed Bigel: A Novel Delivery System for Cannabidiol-Rich Hemp Extract

Gels, Год журнала: 2024, Номер 10(12), С. 770 - 770

Опубликована: Ноя. 26, 2024

The therapeutic potential of Cannabis sativa L. extract has gained significant attention due to its diverse medical applications. Sublingual administration remains a common delivery method cannabinoids; however, challenges often arise the inconvenient form and taste. To address these issues, novel bigel formulation was developed, combining water oil phases enhance stability bioavailability. This incorporates cannabidiol-rich hemp extract, hyaluronic acid for moisturizing properties, taste-masking agent improve patient compliance comfort. Using standardized rich in cannabinoids well-characterized terpene profile, printability bigels evaluated through 3D printing technology. A printout with known cannabidiol (CBD) cannabidiolic (CBDA) content 11.613 mg ± 0.192 CBD 4.732 0.280 CBDA obtained. In addition, release profile determine efficiency active ingredient—dissolved ingredient levels ranged from 74.84% 0.50 80.87% 3.20 80.84 1.33 98.31 1.70 depending on formulation. Rheological studies were conducted evaluate viscosity under varying temperature conditions, ensuring their usability. Findings suggest that this 3D-printed could significantly cannabis extracts, offering more convenient effective option patients. research underscores importance innovation cannabinoid therapies paves way further advancements personalized medicine.

Язык: Английский

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From Waste to Resource: Mineral and Biochemical Characterization of Hemp By-Products in the Fiber and Seed Supply Chain

Agronomy, Год журнала: 2025, Номер 15(3), С. 564 - 564

Опубликована: Фев. 25, 2025

Industrial hemp (Cannabis sativa L.) is a versatile and sustainable multipurpose plant for agroecology services zero-waste circular economy. While the focus has traditionally been on primary products like fiber seeds, nowadays there an increasing awareness of potential value by-products generated during cultivation processing. This article explores various methods valorizing industrial wastes, focusing their mineral biochemical composition, highlighting benefits utilizing what was once considered mere by-product. The apical basal leaves 12 varieties, six monoecious, dioecious, representing main by-product supply chain, were assessed (N, K, Na, Ca; Mg, Cu, Mn, Fe, Zn), chlorophyll, carotenoids, total soluble phenols contents, as well antioxidant activity. same parameters also evaluated in inflorescences; waste derived from both seed harvesting, which collected at three stages flower development four selected genotypes, together with yield chemical composition essential oils. Differences among genotypes tissues highlighted, showing diversifying utilization wastes. possible uses these residual biomasses are discussed based composition.

Язык: Английский

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Fatty Acid Composition and Bioactive Profiles in the Aerial Parts of Cannabis sativa

Molecules, Год журнала: 2025, Номер 30(9), С. 1947 - 1947

Опубликована: Апрель 27, 2025

The interest in Cannabis sativa L. has been on the rise recently, driven by its potential applications various sectors, including food industry, medical sector, and other key areas. This crop possesses a diverse profile of essential fatty acids range bioactive compounds, which exhibit properties that are highly significant for functional ingredients nutraceutical purposes. objective this study was to investigate characteristic lipid profiles different plant parts (e.g., inflorescences leaves) ascertain their possible uses nutritional therapeutic fields. fat content material determined Soxhlet method, gas chromatography employed assessment selected compounds profile. In addition, some quality indices were calculated with purpose providing more in-depth discussion these aspects beyond traditional n-6/n-3 ratio. A distinct composition evident among parts. Compared inflorescence samples, leaves typically contain higher proportions SFAs, MUFAs, PUFAs, n-3 acids, along favorable ratio, may significantly impact value. Phytol-rich can suggest application as feed or even nutraceutical. Furthermore, occurrence hexacosane related antimicrobial antifungal serves enhance practical utility leaves. Notably, hemp not merely by-product, but rather offer applications.

Язык: Английский

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Integrated physiological, microbial, and metabolomics analyses revealed the differences in different varieties of Paeonia lactiflora Pall

Frontiers in Plant Science, Год журнала: 2025, Номер 16

Опубликована: Май 23, 2025

Paeonia lactiflora Pall ( P. ) is a perennial herb with high medicinal and economic value. In the growth process of , plant’s root secondary metabolism intricately linked to microbial communities that surround it. However, few systematic studies have reported changes in microbiome metabolites during cultivation thus far. this study, amplicon sequencing technology was used determine difference rhizosphere microorganisms . The non-targeted metabolomics method metabolites, relationship between demonstrated by co-expression network analysis. paeoniflorin content (PC) determined HPLC. total phenol (TPC) Folin–Ciocalteu method, flavonoid (TFC) NaNO 2 -Al (NO 3 method. antioxidants were evaluated DPPH, ABTS, FRAP methods. Results showed Proteobacteria had highest relative abundance among all phyla, Halomonas genera. results 693 207 differential detected four groups, which mainly enriched biosynthesis phenylpropanoids, phenylpropanoid biosynthesis, taste transduction, central carbon cancer, plant metabolites. also PC, TPC, TFC, antioxidant capacity white group higher than those other groups. This study revealed differences different varieties provided theoretical support for breeding data reference improving quality regulating species.

Язык: Английский

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Antioxidative Response and Phenolic Content of Young Industrial Hemp Leaves at Different Light and Mycorrhiza

Plants, Год журнала: 2024, Номер 13(6), С. 840 - 840

Опубликована: Март 14, 2024

Due to the increasing presence of industrial hemp (Cannabis sativa L.) and its multiple possibilities use, influence different light several biopreparations based on beneficial fungi bacteria hemp’s morphological physiological properties were examined. Different their combinations inoculated seed and/or substrate grown under blue white light. A completely randomized block design was conducted in four replications within 30 days. For biopreparation treatment, vesicular arbuscular mycorrhiza (VAM) combination with Azotobacter chroococum Trichoderma spp. only or both substrate. Generally, highest parameters (stem, root plant length) recorded plants treatment applied spp., Blue negatively affected treatments, resulting lower values all compared control. Leaves pigments higher light, as At same time, 1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), flavonoids, total flavanol content phenolic acids not influenced by type. Biopreparation treatments did significantly leaves’ (Chl a, Chl b Car), nor content.

Язык: Английский

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The Potential of Hemp Extracts to Modify the Course of Oxidative-Stress Related Conditions

Plants, Год журнала: 2024, Номер 13(12), С. 1630 - 1630

Опубликована: Июнь 13, 2024

The leaves of industrial hemp, which have long been considered as a waste product, proven to contain numerous compounds that possess potential biological activity. One the most interesting groups present are polyphenolic compounds, which, due their specific structure, pronounced antioxidant and antihyperglycemic potential. This study aimed detect activity, including potential, water water–alcoholic extracts five commercially available hemp teas, followed by phytochemical profiling. Hemp aqueous ethanolic demonstrate potent properties. Ethanol better scavengers DPPH• OH•, while neutralize NO• better. Both types exhibit in catalase test moderate XOD inhibition. Furthermore, α-amylase inhibitors, stronger anti-α-glucosidase suggesting therapeutic for chronic diseases like insulin resistance or diabetes. Further detailed chemical characterization vivo studies needed validate these findings.

Язык: Английский

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