Balneo and PRM Research Journal,
Год журнала:
2023,
Номер
Vol.14, no.3, С. 591 - 591
Опубликована: Сен. 1, 2023
Primary
fibroblast
cultures
obtained
from
Wistar
rats
were
investigated
with
a
focus
on
two
vital
physiological
mechanisms:
inflammatory
processes
and
oxidative
stress
balance.
These
are
believed
to
be
affected
by
mud
sulfurous
natural
mineral
waters,
forming
the
fundamental
biological
basis
for
understanding
therapeutic
effects
of
these
substances.
Existing
scientific
research
highlights
that
various
cell
types,
including
fibroblasts,
recruited
during
inflammation.
cells
respond
wide
array
intercellular
microenvironmental
signals,
leading
regulated
production
both
pro-
anti-inflammatory
mediators.
Examples
include
cytokines
such
as
tumor
necrosis
factor
(TNF)-α,
interleukin
(IL)-1β,
IL-6,
well
chemokines
enzymes
like
cyclooxygenase
(COX)-2.
Together,
play
roles
in
modulating
response.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
This
article
provides
an
overview
of
the
advancements
in
application
fecal
microbiota
transplantation
(FMT)
treating
diseases
related
to
intestinal
dysbiosis.
FMT
involves
transfer
healthy
donor
into
patient's
body,
aiming
restore
balance
and
thereby
treat
a
variety
such
as
recurrent
Clostridioides
difficile
infection
(rCDI),
inflammatory
bowel
disease
(IBD),
constipation,
short
syndrome
(SBS),
irritable
(IBS).
While
has
shown
high
efficacy
treatment
rCDI,
further
research
is
needed
for
its
other
chronic
conditions.
elaborates
on
mechanisms
dysbiosis,
well
discusses
key
factors
influencing
effectiveness
FMT,
including
selection,
recipient
characteristics,
protocols,
methods
assessing
microbiota.
Additionally,
it
emphasizes
successful
FMT.
Future
should
focus
optimizing
process
ensure
long‐term
safety
explore
potential
broader
range
medical
Critical Reviews in Microbiology,
Год журнала:
2024,
Номер
unknown, С. 1 - 31
Опубликована: Апрель 11, 2024
Periodontitis
is
an
immuno-inflammatory
disease
of
the
soft
tissues
surrounding
teeth.
linked
to
many
communicable
and
non-communicable
diseases
such
as
diabetes,
cardiovascular
disease,
rheumatoid
arthritis,
cancers.
The
oral-systemic
link
between
periodontal
systemic
attributed
spread
inflammation,
microbial
products
microbes
distant
organ
systems.
Oral
bacteria
reach
gut
via
swallowed
saliva,
whereby
they
induce
dysbiosis
gastrointestinal
dysfunctions.
Some
pathogens
like
Porphyromonas.
gingivalis,
Klebsiella,
Helicobacter.
Pylori,
Streptococcus,
Veillonella,
Parvimonas
micra,
Fusobacterium
nucleatum,
Peptostreptococcus,
Haemophilus,
Aggregatibacter
actinomycetomcommitans
Streptococcus
mutans
can
withstand
unfavorable
acidic,
survive
in
result
dysbiosis.
Gut
increases
dysplastic
changes
that
lead
dysfunction.
Various
studies
have
oral
bacteria,
oral-gut
axis
various
GIT
disorders
inflammatory
bowel
liver
diseases,
hepatocellular
pancreatic
ductal
carcinoma,
ulcerative
colitis,
Crohn's
disease.
Although
correlation
periodontitis
well
established,
intricate
molecular
mechanisms
by
which
microflora
these
not
been
discussed
extensively.
This
review
comprehensively
discusses
unique
immunological
Microbiology Spectrum,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
ABSTRACT
Systemic
sclerosis
(SSc)
is
an
autoimmune
disease
with
progressive
fibrotic
disorders
in
multiple
organs.
Mesenchymal
stem
cells
(MSCs)
have
shown
great
potential
treating
SSc,
but
the
exact
regulatory
mechanism
not
fully
understood.
In
this
study,
we
used
human
umbilical
cord-derived
MSCs
(hUC-MSCs)
to
treat
SSc
mice
induced
by
bleomycin.
The
gut
microbiota
composition
and
predicted
functions
were
analyzed
using
2bRAD
sequencing
of
fecal
samples
from
control,
MSCs-treated
mice.
Treatment
improved
bleomycin-induced
mice,
characterized
significantly
reduced
collagen
deposition
dermal
thickness.
exhibited
lower
species
evenness
was
clearly
separated
control
based
on
beta
diversity.
MSC
treatment
led
a
significant
reduction
conditionally
pathogenic
bacteria
enriched
including
Akkermansia
muciniphila
Parasutterella
excrementihominis
.
Conversely,
relative
abundance
butyrate-producing
bacteria,
such
as
Roseburia
,
Butyricicoccus
porcorum
Gemmiger
formicilis
notably
increased
Additionally,
functional
analysis
revealed
that
intervention
effectively
enhanced
sulfur
metabolism,
tryptophan
citrate
cycle,
RNA
polymerase,
beta-lactam
resistance.
summary,
findings
present
study
suggested
close
association
between
metabolic
dysbiosis
SSc.
administration
has
been
regulate
disrupted
pathways
thus
restoring
normal
function
microbiota.
This
provides
valuable
insights
into
specific
involved
efficacy
treatment,
thereby
proposing
novel
therapeutic
strategy
for
IMPORTANCE
Human
mesenchymal
(HUC‑MSCs)
demonstrate
alleviating
skin
thickening
systemic
which
also
function.
Specifically,
leads
notable
increase
decrease
reversal
dysregulated
microbial
These
underscore
significance
effects
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 5, 2024
The
source
of
protein
in
a
persons
diet
affects
their
total
life
expectancy.
However,
the
mechanisms
by
which
dietary
sources
differentially
impact
human
health
and
expectancy
are
poorly
understood.
Dietary
choices
have
major
impacts
on
composition
function
intestinal
microbiota
that
ultimately
mediate
host
health.
This
raises
possibility
outcomes
based
might
be
driven
interactions
between
gut
microbiota.
In
this
study,
we
determine
effects
seven
different
mice.
We
apply
an
integrated
metagenomics-metaproteomics
approach
to
simultaneously
investigate
these
microbiotas
function.
abundances
measured
metaproteomics
can
provide
microbial
species
abundances,
evidence
for
phenotype
members
molecular
level
because
proteins
allow
us
infer
metabolic
physiological
processes
used
community.
showed
significantly
altered
overall
Different
led
changes
abundance
amino
acid
degrading
involved
degradation
glycosylations
protein.
particular,
brown
rice
egg
white
increased
enzymes
bacteria
usually
associated
with
mucus
barrier.
These
results
show
change
metabolism,
could
implications
context
mediated
diseases.
Exploration of Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
The
gut
microbiota,
a
complex
ecosystem
of
microorganisms,
plays
an
essential
role
in
maintaining
immune
and
metabolic
homeostasis.
Disruption
this
microbial
balance,
known
as
dysbiosis,
has
been
increasingly
implicated
the
pathogenesis
chronic
inflammatory
conditions,
including
cardiovascular,
gastrointestinal,
autoimmune
diseases,
well
disorders
such
diabetes
obesity.
A
crucial
mechanism
through
which
microbiota
exerts
its
effects
on
host
physiology
is
via
production
bioactive
metabolites.
These
metabolites,
short-chain
fatty
acids,
bile
tryptophan
derivatives,
are
key
modulating
responses
regulating
functions.
Dysbiosis
disrupts
function
these
thereby
contributing
to
dysregulation,
inflammation,
disease
progression.
This
review
examines
microbiota-derived
metabolites
with
focus
their
immunomodulatory
effects.
deeper
understanding
mechanisms
may
open
way
for
novel
therapeutic
strategies
aimed
at
restoring
homeostasis
mitigating
global
burden
diseases.
Biomolecules,
Год журнала:
2024,
Номер
14(6), С. 633 - 633
Опубликована: Май 29, 2024
Ulcerative
colitis
(UC)
is
an
autoimmune
disease
in
which
the
immune
system
attacks
colon,
leading
to
ulcer
development,
loss
of
colon
function,
and
bloody
diarrhea.
The
human
gut
ecosystem
consists
almost
2000
different
species
bacteria,
forming
a
bioreactor
fueled
by
dietary
micronutrients
produce
bioreactive
compounds,
are
absorbed
our
body
signal
distant
organs.
Studies
have
shown
that
Western
diet,
with
fewer
short-chain
fatty
acids
(SCFAs),
can
alter
microbiome
composition
cause
host's
epigenetic
reprogramming.
Additionally,
overproduction
H
Engineered Regeneration,
Год журнала:
2024,
Номер
5(2), С. 228 - 246
Опубликована: Апрель 17, 2024
The
gut
has
been
a
focal
point
in
the
research
of
digestive
system
disorders.
internal
microbiota
generates
metabolites
that
function
as
signaling
molecules
and
substrates,
interacting
with
intestinal
wall
influencing
host
physiology
pathology.
Besides,
owe
highly
diverse
types
quantities,
posing
challenges
for
quantitative
analysis,
monitoring
frequent
interactions
between
tract
remains
challenge.
However,
targeting
elucidated
their
relevance
to
diseases.
By
modulating
such
short-chain
fatty
acids,
bile
lipopolysaccharides,
it
is
possible
intervene
progression
diseases
inflammatory
bowel
disease
non-alcoholic
liver
disease.
Currently,
on
advancing,
more
work
required
explore
host,
microbes
underlying
mechanisms.
In
this
review,
we
have
revisited
generation
microbiota-related
metabolites,
impact
diseases,
modes
interaction,
emphasizing
significant
role
It
believed
linkage
current
can
be
established
through
providing
framework
foundation
field
metabolomics
fundamental
