Acta Biologica Marisiensis,
Год журнала:
2023,
Номер
6(2), С. 87 - 99
Опубликована: Дек. 1, 2023
Abstract
This
short
overview
explores
the
relationship
between
oxidative
stress
and
mental
disorders,
focusing
on
association
with
psychiatric
pathologies
such
as
Alzheimer’s
disease,
schizophrenia,
autism,
depression,
impact
of
sleep
deprivation.
The
mechanisms
mitochondrial
disfunction
in
these
are
described,
including
physiological
function
limited
free
radicals
signal
transduction,
gene
transcription,
neuronal
plasticity
memory.
Key
radicals,
hydroxyl
superoxide
highlighted,
along
compounds
generating
radicals.
Moreover,
potential
therapeutic
implications
dietary
supplements
(zinc,
selenium,
magnesium,
vitamin
C,
E,
CoQ
10
)
lifestyle
interventions
antioxidant
properties
presented,
laying
groundwork
for
future
research
field
health.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9791 - 9791
Опубликована: Сен. 10, 2024
Grounding,
a
therapeutic
technique
involving
direct
contact
with
the
earth,
has
been
proposed
by
various
studies
to
potentially
have
beneficial
effects
on
pressure,
sleep
quality,
stress,
inflammation,
and
mood.
However,
scientific
evidence
supporting
its
sedative
remains
incomplete.
This
study
examined
effectiveness
of
an
earthing
mat
quality
investigated
underlying
neural
mechanisms
using
electroencephalography
(EEG)
analysis
in
rodents,
focusing
orexin
superoxide
dismutase
(SOD)
levels
brain.
Rats
were
randomly
assigned
four
groups:
naïve
normal
group
(Nor),
exposed
for
7
days
(A-7D),
21
(A-21D),
electronic
blanket
(EM).
EEG
results
revealed
that
A-21D
exhibited
significantly
reduced
wake
time
increased
rapid
eye
movement
(REM),
non-rapid
(NREM),
total
compared
Nor
(p
<
0.05).
Moreover,
demonstrated
significant
increase
NREM
0.001),
REM
0.01),
along
decrease
EM
0.001).
The
level
was
lower
while
SOD1
expression
markedly
elevated
These
suggest
may
represent
promising
new
method
promoting
could
serve
as
effective
technique.
Dietary Supplements and Nutraceuticals,
Год журнала:
2023,
Номер
2(10), С. 41 - 41
Опубликована: Окт. 12, 2023
Background:
Stress
is
a
state
of
imbalance
homeostatic
environment
caused
by
psychological,
environmental,
or
physiologic
stressor.
common
risk
factor
that
involved
in
the
etiopathogenesis
diverse
disorders.
Moreover,
stress
hormones
have
an
immediate
negative
impact
on
glycemic
management.
Purpose
Study:
The
aim
our
study
to
investigate
glucometabolic
potentialof
Cellgevity®
under
conditions
male
Sprague-Dawley
rats.
We
employed
cold
restraint
effectively
induce
physically
and
psychologically
stressed
condition.
Methods:
Twenty-four
(24)
rats
(207±20g)
were
divided
into
four
groups
at
random:
No
Placebo
(NSP),
no
cellgevity
(NSCG),
placebo
(STP),
cell
(STCG).
(immobilization)
was
performed
2hr
daily
morning
using
cylindrical
cage
(8:00
h±
10:00
h.),
for
2
hr
afternoon
(16:00
18:00
h).
enzyme-linked
immunosorbent
assay
used
assess
circulating
insulin
corticosterone
levels.
glucose
tolerance
test
(GTT)
(ITT),
as
well
expression
G6PDH,
alpha-amylase,
alpha-glucosidase
enzymes
evaluated
metabolism.
Biochemical
parameters
such
Lipid
profile,
liver
enzymes,
oxidative
also
determined.
Results:
STP
had
increased
levels,
elevated
resistance,
dyslipidemia,
damage.
Furthermore,
improved
levels
but
effect
tolerance.
However,
mitigates
stress-induced
damage
causing
reduction
modulating
serum
markers
metabolic
indices.
Keywords:Cold-restraint
Stress,
Glucose
Tolerance,
Insulin
Sensitivity,
Corticosterone,
stress.
Dietary Supplements and Nutraceuticals,
Год журнала:
2023,
Номер
2(10), С. 41 - 41
Опубликована: Окт. 12, 2023
Background:
Stress
is
a
state
of
imbalance
homeostatic
environment
caused
by
psychological,
environmental,
or
physiologic
stressor.
common
risk
factor
that
involved
in
the
etiopathogenesis
diverse
disorders.
Moreover,
stress
hormones
have
an
immediate
negative
impact
on
glycemic
management.
Purpose
Study:
The
aim
our
study
to
investigate
glucometabolic
potentialof
Cellgevity®
under
conditions
male
Sprague-Dawley
rats.
We
employed
cold
restraint
effectively
induce
physically
and
psychologically
stressed
condition.
Methods:
Twenty-four
(24)
rats
(207±20g)
were
divided
into
four
groups
at
random:
No
Placebo
(NSP),
no
cellgevity
(NSCG),
placebo
(STP),
cell
(STCG).
(immobilization)
was
performed
2hr
daily
morning
using
cylindrical
cage
(8:00
h±
10:00
h.),
for
2
hr
afternoon
(16:00
18:00
h).
enzyme-linked
immunosorbent
assay
used
assess
circulating
insulin
corticosterone
levels.
glucose
tolerance
test
(GTT)
(ITT),
as
well
expression
G6PDH,
alpha-amylase,
alpha-glucosidase
enzymes
evaluated
metabolism.
Biochemical
parameters
such
Lipid
profile,
liver
enzymes,
oxidative
also
determined.
Results:
STP
had
increased
levels,
elevated
resistance,
dyslipidemia,
damage.
Furthermore,
improved
levels
but
effect
tolerance.
However,
mitigates
stress-induced
damage
causing
reduction
modulating
serum
markers
metabolic
indices.
Keywords:Cold-restraint
Stress,
Glucose
Tolerance,
Insulin
Sensitivity,
Corticosterone,
stress.
Acta Biologica Marisiensis,
Год журнала:
2023,
Номер
6(2), С. 87 - 99
Опубликована: Дек. 1, 2023
Abstract
This
short
overview
explores
the
relationship
between
oxidative
stress
and
mental
disorders,
focusing
on
association
with
psychiatric
pathologies
such
as
Alzheimer’s
disease,
schizophrenia,
autism,
depression,
impact
of
sleep
deprivation.
The
mechanisms
mitochondrial
disfunction
in
these
are
described,
including
physiological
function
limited
free
radicals
signal
transduction,
gene
transcription,
neuronal
plasticity
memory.
Key
radicals,
hydroxyl
superoxide
highlighted,
along
compounds
generating
radicals.
Moreover,
potential
therapeutic
implications
dietary
supplements
(zinc,
selenium,
magnesium,
vitamin
C,
E,
CoQ
10
)
lifestyle
interventions
antioxidant
properties
presented,
laying
groundwork
for
future
research
field
health.
