COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14876 - 14876

Опубликована: Окт. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Язык: Английский

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The Use and Potential Benefits of N-Acetylcysteine in Non-Acetaminophen Acute Liver Failure: An Etiology-Based Review

Biomedicines, Год журнала: 2024, Номер 12(3), С. 676 - 676

Опубликована: Март 18, 2024

Acute liver failure represents a life-threatening organ dysfunction with high mortality rates and an urgent need for transplantation. The etiology of the disease varies widely depending on various socio-economic factors is represented mainly by paracetamol overdose other drug-induced forms in developed world viral hepatitis mushroom poisoning less countries. Current medical care constitutes either specific antidotes or supportive measures to ensure spontaneous recovery. Although it has been proven have beneficial effects paracetamol-induced failure, N-acetylcysteine used all acute failure. Despite this, few well-designed studies conducted assessment potential benefits, dose regimens, route administration non-acetaminophen This review aims summarize current evidence behind use this drug different

Язык: Английский

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Toxicological impact of strobilurin fungicides on human and environmental health: a literature review

Journal of Environmental Science and Health Part B, Год журнала: 2024, Номер 59(4), С. 142 - 151

Опубликована: Фев. 11, 2024

Fungicides are specifically used for controlling fungal infections. Strobilurins, a class of fungicides originating from the mushroom Strobilurus tenacellus, act on mitochondrial respiratory chain, interrupting ATP cycle and causing oxidative stress. Although strobilurins little soluble in water, they have been detected water samples (such as rainwater drinking water), indoor dust, sediments, can bioaccumulate aquatic organisms. Strobilurins usually absorbed orally mainly eliminated via bile/fecal route urine, but information about their metabolites is lacking. low mammalian toxicity; however, exert severe toxic effects Mitochondrial dysfunction stress main mechanisms related to genotoxic damage elicited by compounds, such strobilurins. These alter genes cause other dysfunctions, including hormonal, cardiac, neurological, immunological impairment. Despite limitations, we able compile literature Many studies dealt with effects, further investigations needed clarify cellular underlying mechanisms, which will help find ways minimize harmful these compounds.

Язык: Английский

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Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals

Current Opinion in Virology, Год журнала: 2024, Номер 67, С. 101423 - 101423

Опубликована: Июнь 25, 2024

Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis, with risk for the development hepatocellular carcinoma (HCC). Although highly effective direct-acting antivirals (DAAs) are available, incidence, morbidity, mortality HCV-associated HCC still high. This article reviews current knowledge mechanisms HCV-induced carcinogenesis special focus on those processes that continue after clearance outlines implications patient surveillance DAA treatment.

Язык: Английский

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Caffeic acid ameliorates metabolic dysfunction-associated steatotic liver disease via alleviating oxidative damage and lipid accumulation in hepatocytes through activating Nrf2 via targeting Keap1

Free Radical Biology and Medicine, Год журнала: 2024, Номер 224, С. 352 - 365

Опубликована: Авг. 28, 2024

Язык: Английский

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Oxidative Stress Early After Hematopoietic Stem Cell Transplant

Transplantation and Cellular Therapy, Год журнала: 2025, Номер 31(3), С. 135.e1 - 135.e10

Опубликована: Янв. 13, 2025

Язык: Английский

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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease

Annals of Hepatology, Год журнала: 2025, Номер unknown, С. 101777 - 101777

Опубликована: Янв. 1, 2025

Non-alcoholic fatty liver disease (NAFLD), now recognized as metabolic dysfunction-associated steatotic (MASLD), represents a significant and escalating global health challenge. Its prevalence is intricately linked to obesity, insulin resistance, other components of the syndrome. As our comprehension MASLD deepens, it has become evident that this condition extends beyond liver, embodying complex, multi-systemic with hepatic manifestations mirror broader landscape. This comprehensive review delves into critical interplay between gut-liver axis oxidative stress, elucidating their pivotal roles in etiology progression MASLD. Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger stress through enhanced ROS production hepatocytes Kupffer cells, leading mitochondrial dysfunction lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation endotoxins like LPS, which activate inflammatory pathways TLR4 signaling promote via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB Nrf2 serve crucial mediators axis, regulating responses orchestrating antioxidant defenses; (4) Oxidative stress-induced damage function creates destructive feedback loop, further exacerbating inflammation progression. These findings highlight complex interrelationship pathogenesis, suggesting potential therapeutic targets for management.

Язык: Английский

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A network toxicology and molecular docking-based approach revealed shared hepatotoxic mechanisms and targets between the herbicide 2,4-D and its metabolite 2,4-DCP

Toxicology, Год журнала: 2025, Номер unknown, С. 154086 - 154086

Опубликована: Фев. 1, 2025

Язык: Английский

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Safety of Nutmeg powder by oral exposure: toxicity prediction and in vivo evaluation

Food and Chemical Toxicology, Год журнала: 2025, Номер 200, С. 115364 - 115364

Опубликована: Март 1, 2025

Язык: Английский

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The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, predominantly associated with chronic hepatitis B virus (HBV) and C (HCV) infections. These infections drive persistent liver inflammation, culminating in cellular dysregulation, fibrosis, cancer. Despite advancements targeted therapies, drug resistance the lack reliable biomarkers for patient stratification still terribly hinder treatment viral HCC. To this end, review delves into intricate mechanisms underlying malignant transformation to HCC, including integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, immune escape, abnormal signaling pathways, highlighting their complex interactions synergies. Cutting-edge preclinical clinical HCC management, lifestyle immunotherapies, gene-based approaches, innovative treatments, are further investigated, particular priority given therapeutic potential future applications overcoming current limitations. By synthesizing recent scientific insights, aims deepen understanding pathogenesis context hepatitis, paving way novel targets personalized strategies, ultimately improving outcomes.

Язык: Английский

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