Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

Foods, Год журнала: 2024, Номер 13(11), С. 1774 - 1774

Опубликована: Июнь 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Язык: Английский

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Free radicals and their impact on health and antioxidant defenses: a review

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 24, 2025

Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated

Язык: Английский

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Astaxanthin Inhibits H2O2-Induced Excessive Mitophagy and Apoptosis in SH-SY5Y Cells by Regulation of Akt/mTOR Activation

Marine Drugs, Год журнала: 2024, Номер 22(2), С. 57 - 57

Опубликована: Янв. 24, 2024

Oxidative stress, which damages cellular components and causes mitochondrial dysfunction, occurs in a variety of human diseases, including neurological disorders. The clearance damaged mitochondria via mitophagy maintains the normal function facilitates cell survival. Astaxanthin is an antioxidant known to have neuroprotective effects, but underlying mechanisms remain unclear. This study demonstrated that astaxanthin inhibited H

Язык: Английский

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Antioxidant, anti-amylase, anti-lipase, and efficiency of Satureja fatty acid on the anti-inflammatory parameters in lipopolysaccharide-stimulated macrophage through Nrf2/NF-kB/NADH oxidase pathway

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 31, 2024

Abstract Satureja is an aromatic plant that used for flavoring, perfume, and food manufacturing due to its pleasant essential oil. Modern medicine research revealed several biological activities of oil, including antifungal, antibacterial, antiviral, antioxidant, anticancer, anti-inflammatory. However, the functional properties fatty acid have not been explored. This study examined profile, lipid nutritional quality, anti-amylase, anti-lipase capacities . The efficiency on anti-oxidative anti-inflammatory parameters in LPS-induced macrophage through Nrf2/NF-kB/NADH oxidase pathway was examined. whole extract prepared with chloroform/methanol/water solution. Fatty acids methyl ester from were methanol/sulfuric reagent. profile analyzed using gas chromatography-mass spectrometry. Total antioxidant determined by ABTS decolorization. Lipase amylase monitoring decomposition p -nitrophenyl butyrate starch. cell line grown DMEM media presence acid. hydrogen peroxide production treated cells monitored FOX NADH activity measured breakdown. expression NOX, NF-kB, NRF2, tested real-time PCR. main components linolenic (24.67–37.32%), palmitic (10.65–20.29%), linoleic (8.31–13.39%), oleic (4.42–14.35%), stearic (2.76–8.77%) palmitoleic (1.77–4.95%). Given omega-3 PUFA (23.58–37.32%), SFA (21.53–26.70%), omega-6 (10.86–16.14%), omega-9 MUFA omega-7 (1.77–4.95%) comprise majority acids. has a promising unsaturation index (120.77–164.27), PUFA/MUFA (2.07–6.41), hypocholesterolemic (2.44–3.47), health-promoting (2.03–2.42), PUFA/SFA (1.37–1.94), nutritive value (0.53–1.71), MUFA/SFA (0.30–0.80) omega-6/omega-3 (0.34–0.65), atherogenicity (0.41–0.49), thrombogenicity (0.17–0.27). displayed strong capacity (with IC 50 ranging 354 428 µg/mL), anti-amylase 370 390 µg/mL). LPS induced NF-kB synthesis cells. In LPS-stimulated macrophages, reduced NOX expression, peroxide, increased NRF2 at 0.04 mg/mL. conclusion, potent anti-lipase, activities. mechanisms lowering oxidative stress markers depended down-regulating superoxide-producing enzymes gene protein levels. polyunsaturated could be recommended healthy products combined dietary therapy treat obesity, diabetes, stress.

Язык: Английский

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Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1086 - 1086

Опубликована: Янв. 16, 2024

Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology not well understood. It known that genetic nongenetic factors determine alterations in several organs, such as the liver, individuals with this disorder. The aims of present study were to analyze morphological biological liver an autistic mouse model, BTBR T + Itpr3tf/J (BTBR) mice, identify therapeutic strategies for alleviating hepatic impairments using melatonin administration. We studied cytoarchitecture, oxidative stress, inflammation ferroptosis mice used C57BL6/J healthy control subjects. divided into four groups then treated melatonin, respectively. showed (a) retarded development livers (b) iron accumulation elevated stress inflammation. demonstrated expression markers, transcription factor nuclear erythroid-related 2 (NFR2), was upregulated, Kelch-like ECH-associated protein 1 (KEAP1) downregulated mice. Then, we evaluated effects on mice; has positive effect cytoarchitecture metabolic functions.

Язык: Английский

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Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects

Antioxidants, Год журнала: 2024, Номер 13(3), С. 265 - 265

Опубликована: Фев. 22, 2024

Manganosalen complexes are a class of catalytic antioxidants with beneficial effects against different neurological disorders according to various in vitro and vivo studies. The interest the factors that determine their antioxidant activity is based on fact they key achieving more efficient models. In this work, we report set new manganosalen complexes, thoroughly characterized solid state solution by techniques. chelating Schiff base ligands used were prepared from condensation substituted hydroxybenzaldehydes 1,2-diaminoethane 1,3-diaminopropane. models was tested through superoxide dismutase catalase probes conjunction studies about neuroprotective human SH-SY5Y neuroblastoma cells an oxidative stress model. ability scavenge excess reactive oxygen species (ROS) varied depending models, which also yielded improvements cell survival. An assessment affect oxidant for these others previously reported, revealed major influence structural versus redox properties complexes.

Язык: Английский

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Metritis and the uterine disease microbiome are associated with long-term changes in the endometrium of dairy cows

Biology of Reproduction, Год журнала: 2024, Номер 111(2), С. 332 - 350

Опубликована: Май 5, 2024

Cows with metritis (uterine disease) during the first 1 to 2 weeks postpartum have lower pregnancy rates when inseminated later (typically >10 weeks). We hypothesized that and disease-associated uterine microbiome a long-term effect on endometrial gene expression. Changes in expression may inform mechanism through which disease lowers rates. A total of 20 cows were enrolled at either (clinical disease; n = 10) or healthy (control; groups randomly assigned be slaughtered approximately 80 165 dpp (mid-lactation). The reproductive tract was sampled confirm presence pathogens are typical metritis. In addition original clinical diagnosis, study retrospectively uterine-disease control based composition their microbiome. There no early mid-lactation (time slaughter). Nonetheless, associated large number differentially-expressed genes primarily caruncular compared inter-caruncular endometrium. Gene enrichment analysis identified oxidative phosphorylation as primary pathway increased endometrium diseased whereas growth factor signaling pathways reduced. current demonstrated leave sustained imprint explain fertility disease.

Язык: Английский

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The Antioxidant Role of Aromatic Plant Extracts in Managing Neurodegenerative Diseases: A Comprehensive Review

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111253 - 111253

Опубликована: Фев. 1, 2025

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Amyotrophic Lateral Sclerosis (ALS), others. They caused by lesions in cells tissues the central nervous system, resulting corresponding dysfunctions consequent decline functions. Neural extremely vulnerable to oxidative stress, which plays critical biological roles NDDs. Aromatic compounds found extensively natural plants have substantial effects anti-oxidative stress damage, not only wide range research applications cosmetics, foods, etc., but also frequently utilized treatment various system diseases. This review summarizes relevant mechanisms NDDs (AD, PD, HD, ALS) reviews aromatic such as polyphenols, terpenoids, flavonoids that can be used management neurodegenerative diseases, well their specific antioxidant action. will serve reference for future experimental studies on illnesses while offering fresh insights into clinical therapy.

Язык: Английский

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Astaxanthin in cancer therapy and prevention (Review)

Biomedical Reports, Год журнала: 2025, Номер 22(4)

Опубликована: Фев. 14, 2025

Astaxanthin (AXT), a carotenoid primarily derived from marine organisms such as shrimp, krill and the microalga Haematococcus pluvialis, has gained significant attention for its potent antioxidant, anti‑inflammatory anti‑proliferative properties. The present comprehensive review explored role of AXT in cancer prevention treatment, emphasizing cytotoxic mechanisms modulation key molecular pathways involved progression. demonstrated efficacy across variety types, including nervous system, breast gastrointestinal cancers, through ability to induce apoptosis, inhibit metastasis disrupt cell growth. detailed both in vitro vivo studies highlighting effectiveness sensitizing cells chemotherapy, thereby enhancing therapeutic outcomes potentially reducing treatment‑related side effects. incorporation nanoparticle‑based delivery systems further improved bioavailability targeted action, showcasing potential advanced therapies. However, despite promising experimental results, more clinical trials are necessary validate safety human populations. Such research would help standardize dosing, confirm interactions with conventional treatments support integration into oncology natural, complementary approach existing treatments.

Язык: Английский

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The Dual Role of Oxidative Stress in Atherosclerosis and Coronary Artery Disease: Pathological Mechanisms and Diagnostic Potential

Antioxidants, Год журнала: 2025, Номер 14(3), С. 275 - 275

Опубликована: Фев. 26, 2025

Oxidative stress plays a pivotal role in the pathogenesis of atherosclerosis and coronary artery disease (CAD), with both beneficial detrimental effects on cardiovascular health. On one hand, excessive production reactive oxygen species (ROS) contributes to endothelial dysfunction, inflammation, vascular remodeling, which are central development progression CAD. These pathological drive key processes such as atherosclerosis, plaque formation, thrombosis. other moderate levels oxidative can have include regulating tone by promoting blood vessel dilation, supporting function through nitric oxide production, enhancing immune response prevent infections. Additionally, stimulate cellular adaptation stress, promote cell survival, encourage angiogenesis, helps form new vessels improve flow. also holds promise source biomarkers that could aid diagnosis, prognosis, monitoring Specific markers, malondialdehyde (MDA), isoprostanes (isoP), ischemia-modified albumin, antioxidant enzyme activity, been identified potential indicators severity therapeutic response. This review explores dual nature CAD, examining its mechanisms well emerging clinical diagnostics targeted therapies. The future directions for research aimed at harnessing diagnostic discussed. Understanding balance between lead innovative approaches prevention management

Язык: Английский

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