Menopause and metabolic dysfunction-associated steatotic liver disease

Maturitas, Год журнала: 2024, Номер 186, С. 108024 - 108024

Опубликована: Май 14, 2024

Язык: Английский

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MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women

Biomedicines, Год журнала: 2025, Номер 13(4), С. 855 - 855

Опубликована: Апрель 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Язык: Английский

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Expression of Estrogen Receptors in Main Immune Organs in Sheep During Early Pregnancy

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3528 - 3528

Опубликована: Апрель 9, 2025

Estrogen exerts its action via estrogen receptors (ERs), including ERα and ERβ, has effects on immunomodulation during pregnancy. It is known that there are changes in the function of maternal immune organs However, it not clear if early pregnancy expression ERβ ovine thymus, lymph nodes, spleen, liver. In this study, these were harvested at day 16 estrous cycle days 13, 16, 25 (n = 6 for each group) after ewes euthanized. The mRNA protein analyzed using real-time PCR Western blot immunohistochemical analyses. results reveal both upregulated spleen liver was modulated conclusion, modulates a tissue-specific manner, which related to regulation ewes.

Язык: Английский

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Shenling Baizhu San Alleviates Central Fatigue through SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119110 - 119110

Опубликована: Ноя. 1, 2024

Язык: Английский

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SIRT1 in acute lung injury: unraveling its pleiotropic functions and therapeutic development prospects

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Язык: Английский

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