Recent approaches in nanotoxicity assessment for drug delivery applications: Challenges and prospects

Medicine in Drug Discovery, Год журнала: 2025, Номер unknown, С. 100204 - 100204

Опубликована: Фев. 1, 2025

Язык: Английский

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Antimicrobial activity and mechanisms of carbon quantum dot decorated modified zinc oxide nanoparticles against oral pathogenic bacteria

Results in Chemistry, Год журнала: 2024, Номер 9, С. 101655 - 101655

Опубликована: Июль 1, 2024

Caries represents one of the most prevalent bacterial infectious diseases in oral cavity. Over decades, researchers have been actively seeking nanomaterials capable inhibiting pathogenic bacteria. We utilized a one-pot hydrothermal method to synthesize CQDs with multicolor luminescence and CQD-loaded ZnO composite nanomaterials. FE-SEM revealed that rod-like structure CQDs/ZnO becomes finer increased content. XRD XPS confirmed presence all components within nanocomposites. compared antimicrobial activities ZnO, 7.7% 14.3% against Streptococcus mutans, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus. The exhibited effective antibacterial activity. ONPG assays demonstrated disrupted membrane alters permeability. ESR, DPBF ROS assayed further 1O2 produced by accumulated at cell disrupts its structure.

Язык: Английский

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Impact of extraction techniques and process optimization on antioxidant and antibacterial potential of Kalanchoe pinnata leaf extract

International Journal of Food Properties, Год журнала: 2024, Номер 27(1), С. 909 - 926

Опубликована: Июль 7, 2024

Kalanchoe pinnata (Lam.) Pers. is an ethnomedicinal plant known for its antioxidant, antibacterial, and therapeutic potential. The current study was effort to explore the impact of extraction technique on phytochemical, antibacterial profile extracts. K. leaf extracts were prepared using conventional solvent (100% methanol; 50% methanol: water; 100% water), microwave-assisted at 700-W power (3 min; 6 9 min), supercritical fluid (SFE) (3500 psi; 4500 5500 psi). Best results attained from SFE in terms total phenolic content (240 ± 3 mg GAE/g), flavonoid (165.2 0.4 QE/g), 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential (91.9 0.4%), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid assay value (8.04 0.03 mMol TE/g) ferric reducing antioxidant (471.7 0.8 µg/mL). have been found be most effective against Yersinia pseudotuberculosis (22.20 0.95 mm) least againstProteus vulgaris (0 0 mm). High-performance liquid chromatography analysis extract showed that it contains flavanol quercetin (2.0 0.1 mg/g). It evident findings can effectively treat bacterial infections cure metabolic disorders by oxidative stress. Application advance techniques enhances biological activity

Язык: Английский

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Unravelling the Neuroprotective Effects of a Novel Formulation Based on Plant Extracts, Mg, and Vitamin B6

Nutraceuticals, Год журнала: 2025, Номер 5(1), С. 5 - 5

Опубликована: Янв. 21, 2025

The aim of the present study was to investigate phenolic composition and efficacy an innovative formulation based on Mg, Vitamin B6, water extracts from Vitex agnus-castus, Crocus sativus, Melissa officinalis, Betula pendula, pubescens developed as effective tool face neuroinflammation depression symptoms occurring in premenstrual syndrome (PMS). analyzed through colorimetric liquid chromatography methods for determining content phenols flavonoids. Additionally, scavenging/reducing properties were investigated via 2,2-diphenyl-1-picrylhydrazyl (DPPH,) 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), horseradish peroxidase assays. biocompatible limits determined allelopathy, brine shrimp lethality test, Daphnia magna cardiotoxicity assay. then assayed experimental model constituted by isolated mouse cortex specimens exposed K+ 60 mM Krebs–Ringer buffer, a toxic depolarizing stimulus able reproduce burden inflammation/oxidative stress increased serotonin (5-hydroxytryptamine, 5-HT) impoverishment different neurological psychiatric conditions, including depression. results phytochemical analysis showed that is rich benzoic acids, namely gentisic acid (155.31 µg/mL) phenylethanoid compounds, hydroxytyrosol (39.79 support antioxidant effects measured DPPH (IC50: 1.48 mg/mL), ABTS 0.42 2.02 mg/mL) ecotoxicological models indicated non-toxic, permitting identification concentration (1000 be used buffer. In this model, gene expression cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), estrogen receptor-1 (ESR1), prolactin receptor (PRLR), brain-derived neurotrophic factor (BDNF), transporter (SERT) real-time PCR. cortex, formula reduced COX-2, IL-6, SERT, ESR1, PRLR BDNF IL-10 expression. Overall, corroborated use contrast inflammation, oxidative stress, neurotransmitter impairment associated with PMS.

Язык: Английский

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Lanthanide-Based Core-Shell Nanoconstructs for Cancer Theragnostics

Опубликована: Янв. 1, 2025

Язык: Английский

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Rare-Earth Based Nanomaterials for Sensors: Experimental and Application Perspectives

Опубликована: Янв. 1, 2025

Язык: Английский

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Exploring the cytotoxic and antioxidant properties of lanthanide-doped ZnO nanoparticles: a study with machine learning interpretation

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 10, 2024

Lanthanide-based nanomaterials offer a promising alternative for cancer therapy because of their selectivity and effectiveness, which can be modified predicted by leveraging the improved accuracy enhanced decision-making machine learning (ML) modeling.

Язык: Английский

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Evaluation of biological activity for gadolinium-incorporated zinc oxide nanostructures via hydrothermal method

MRS Advances, Год журнала: 2024, Номер 9(17), С. 1324 - 1330

Опубликована: Май 15, 2024

Язык: Английский

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Evaluation of Superparamagnetic Fe3O4-Ag Decorated Nanoparticles: Cytotoxicity Studies in Human Fibroblasts (HFF-1) and Breast Cancer Cells (MCF-7)

Applied Sciences, Год журнала: 2024, Номер 14(15), С. 6750 - 6750

Опубликована: Авг. 2, 2024

This study investigates the cytotoxicity profile of superparamagnetic Fe3O4-Ag decorated nanoparticles against human fibroblasts (HFF-1) and breast cancer cells (MCF-7). The underwent comprehensive characterization employing scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, photoelectron spectroscopy (XPS), magnetic assays including hysteresis curves zero-field-cooled (ZFC) plots. exhibited behavior as evidenced by studies. Cytotoxicity demonstrated that both HFF-1 MCF-7 maintained nearly 100% viability upon nanoparticle exposure, underscoring outstanding biocompatibility Fe3O4/Ag suggesting their potential utility in biomedical applications such drug delivery targeting. Furthermore, analyzed cytotoxic effects Fe3O4 to evaluate for further therapeutic efficacy. Results showed neither type significantly reduced cell fibroblasts, indicating non-cytotoxicity at tested concentrations. Similarly, did not exhibit a significant change when exposed different concentrations, highlighting compatibility these with healthy cancerous cells. Additionally, production reactive oxygen species (ROS) was examined guarantee biosafety potential. Higher concentrations (50–100 μg/mL) decreased ROS cells, while were more effective generating ROS. differential response suggests might modulate oxidative stress effectively, thus beneficial future anticancer strategies due cells’ susceptibility ROS-induced damage. These findings contribute understanding interactions cellular mechanisms, which are crucial developing safe nanoparticle-based therapies. investigation advances our nanostructured materials biological settings highlights promising prospects biomedicine.

Язык: Английский

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Clean label extraction of bioactive compounds from Chenopodium album and their role in the characterization and stability of ostrich meat

Frontiers in Sustainable Food Systems, Год журнала: 2024, Номер 8

Опубликована: Окт. 8, 2024

The demand for clean-label products continues to rise, as consumers increasingly prioritize natural and transparent ingredient lists. Natural substances are generally deemed safe consumption by consumers. This study was focused on the development of ostrich meat patties with Chenopodium album extract their storage stability. To prepare C. extract, microwave-assisted extraction (MAE) ultrasound-assisted (UAE) were employed. Ostrich prepared using diverse combinations including 1% UAE, 2% MAE, 0.5% UAE+0.5% UAE + MAE. highest pH observed MAE in T3 14th day (6.19 ± 0.03). L* value between 39.12 1.09 44.00 1.1. As intervals passed, a* b* values decreased. After storage, best results obtained from (T2), lowest TBRAS, Peroxide (POV), Total volatile basic nitrogen (TVBN) readings recorded T2 (0.74 0.02 MDA/kg, 0.56 0.01 meq peroxide/kg, 6.28 0.40 mg/100 mL, respectively). At end study, Microbial Count (TMC) coliform count (8.08 0.03 4.97 0.05 cfu/mL, exhibited total phenolic content (TPC), diphenyl-1-picrylhydrazyl (DPPH), Ferric reducing antioxidant power (FRAP), azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assay, namely 122 0.28 mg GAE/100 g, 73 0.27%, 5.9 mmol FSE/100 83 0.08 mmol/L, respectively. current concludes that incorporated into manifests improved safety, quality, implementation clean label strategies can facilitate food manufacturers align consumer preferences product transparency sustainability while ensuring safety quality.

Язык: Английский

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