Processes,
Год журнала:
2024,
Номер
12(10), С. 2060 - 2060
Опубликована: Сен. 24, 2024
A
drug
design
strategy
with
reduced
side
effects
and
economic
feasibility
is
desirable
for
fatal
diseases.
Increasing
the
bioavailability
of
a
using
bioenhancer
smart
strategy.
Herbal/natural
bioenhancers
no
probable
are
an
ideal
choice
to
enhance
pharmacokinetics
therapeutic
synergistically.
The
mechanism
relies
on
retention
molecule
in
cell
without
causing
any
changes
metabolic
activity.
Most
herbal
achieve
this
feat
by
inhibiting
enzymes
such
as
cytochrome
P450
Uridine
5′-diphospho-glucuronosyltransferase.
efflux
pump
p-glycoprotein,
responsible
removal
xenobiotics,
also
inhibited
herbal/natural
bioenhancers.
increased
because
higher
Cmax
tmax
chemotherapeutics
or
anti-infectious
agents
rifampicin
can
result
lower
dosage
regimen.
reduction
directly
linked
fewer
viability.
Further,
there
significant
effort
clinical
trials
incorporate
regimens
cancer.
role
their
potential
augment
therapeutics
used
cancer
infectious
diseases,
focus
mechanisms
action,
studies
patents,
have
been
summarized
review
article.
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 454 - 454
Опубликована: Апрель 10, 2025
Chimeric
Antigen
Receptor
(CAR)
T-cell
therapy
has
revolutionized
the
treatment
of
hematological
malignancies,
demonstrating
high
efficacy
in
targeting
and
eliminating
cancer
cells.
However,
its
clinical
application
can
be
associated
with
risk
acute
adverse
effects,
including
cytokine
release
syndrome
(CRS),
a
severe
inflammatory
response
caused
by
excessive
production.
While
anti-cytokine
therapies
are
available
to
manage
CRS,
additional
strategies
needed
optimize
CAR
reduced
toxicities.
Curcumin,
bioactive
polyphenol
known
for
anti-inflammatory
antioxidant
properties,
represents
promising
adjunct
therapy.
In
this
study,
we
investigated
effects
curcumin
on
anti-CD19
T-cells
vitro.
Our
results
show
that
enhances
cytotoxic
activity
against
Nalm-6,
B-cell
lymphoblastic
leukemia
model,
while
reducing
production
pro-inflammatory
cytokines,
IL-2
IFN-γ.
To
explore
underlying
mechanisms,
network
pharmacology
molecular
docking
analyses
were
performed,
which
revealed
interacts
key
signaling
pathways
involved
activation
regulation.
These
findings
support
potential
as
therapeutic
improve
mitigating
toxicity.
Gels,
Год журнала:
2025,
Номер
11(4), С. 288 - 288
Опубликована: Апрель 14, 2025
Systemic
chemotherapy
is
still
the
first-line
treatment
for
cancer,
and
it’s
associated
with
toxic
side
effects,
chemoresistance,
ultimately
cancer
recurrence.
Rapid
gelling
hydrogels
can
overcome
this
limitation
by
providing
localized
delivery
of
anti-cancer
agents
to
solid
tumors.
Silk
are
extremely
biocompatible
suitable
drug
delivery,
but
faster
formulations
needed.
In
study,
we
introduce
a
rapid
hydrogel
formulation
(<3
min
time)
due
chemical
crosslinking
between
silk
fibroin
curcumin,
initiated
addition
minute
quantities
horseradish
peroxidase
(HRP)
hydrogen
peroxide
(H2O2).
The
novel
observation
in
study
that
while
being
free-radical
scavenger,
also
participates
accelerating
di-tyrosine
presence
HRP
H2O2.
Using
UV-Vis,
rheology,
time-lapse
videos,
convincingly
show
curcumin
accelerates
reaction
concentration-dependent
manner,
remains
entrapped
post-crosslinking.
FTIR
results
an
increase
secondary
beta-sheet
structures
within
hydrogels,
increasing
concentrations
curcumin.
Furthermore,
curcumin-silk
U2OS
osteosarcoma
cells,
most
cells
dead
short
time
scales
4
h
post-encapsulation.
Processes,
Год журнала:
2024,
Номер
12(10), С. 2060 - 2060
Опубликована: Сен. 24, 2024
A
drug
design
strategy
with
reduced
side
effects
and
economic
feasibility
is
desirable
for
fatal
diseases.
Increasing
the
bioavailability
of
a
using
bioenhancer
smart
strategy.
Herbal/natural
bioenhancers
no
probable
are
an
ideal
choice
to
enhance
pharmacokinetics
therapeutic
synergistically.
The
mechanism
relies
on
retention
molecule
in
cell
without
causing
any
changes
metabolic
activity.
Most
herbal
achieve
this
feat
by
inhibiting
enzymes
such
as
cytochrome
P450
Uridine
5′-diphospho-glucuronosyltransferase.
efflux
pump
p-glycoprotein,
responsible
removal
xenobiotics,
also
inhibited
herbal/natural
bioenhancers.
increased
because
higher
Cmax
tmax
chemotherapeutics
or
anti-infectious
agents
rifampicin
can
result
lower
dosage
regimen.
reduction
directly
linked
fewer
viability.
Further,
there
significant
effort
clinical
trials
incorporate
regimens
cancer.
role
their
potential
augment
therapeutics
used
cancer
infectious
diseases,
focus
mechanisms
action,
studies
patents,
have
been
summarized
review
article.
