Identification of Hub Genes for Ferroptosis Associated with Alzheimer's Disease in Entorhinal Cortex and Construction of Predictive Models
Опубликована: Янв. 1, 2025
Язык: Английский
Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders
Frontiers in Physiology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 17, 2025
With
the
global
population
aging,
musculoskeletal
disorders
(MSDs)
have
posed
significant
physical
and
psychological
health
challenges
for
patients
as
well
a
substantial
economic
burden
on
society.
The
advancements
in
conservative
surgical
interventions
MSDs
been
remarkable
recent
years;
however,
current
treatment
modalities
still
fall
short
of
meeting
optimal
requirements
patients.
Recently,
peroxiredoxin
6
(Prdx6)
has
gained
considerable
attention
from
researchers
due
to
its
antioxidative,
anti-inflammatory,
anti-apoptotic
properties.
It
found
that
Prdx6
is
involved
multiple
system
diseases,
including
MSDs;
exact
role
lacking.
This
study
aimed
summarize
structure,
regulatory
mechanism,
potential
function
Prdx6.
These
findings
may
demonstrate
novel
target
inhibiting
advancement
MSDs.
Язык: Английский
Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1033 - 1033
Опубликована: Авг. 26, 2024
Oxidative
stress,
characterized
by
increased
production
of
reactive
oxygen
species
(ROS)
and
disturbed
redox
homeostasis,
is
one
the
key
mechanisms
underlying
synaptic
loss
neuronal
death
in
various
neurodegenerative
diseases
[...]
Язык: Английский
Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
Cellular
senescence
is
a
cell
fate
triggered
by
inherent
or
environmental
stress
and
characterized
stable
cycle
arrest
accompanied
hypersecretory
feature,
termed
as
the
senescence-associated
secretory
phenotype
(SASP).
Senescent
burden
increases
with
natural
aging,
functionally
contributing
to
age-related
organ
dysfunction
multiple
disorders.
In
this
study,
we
performed
large
scale
screening
of
product
library
for
senotherapeutic
candidates
assessing
their
effects
on
human
senescent
cells.
Apigenin,
dietary
flavonoid
previously
reported
antioxidant
anti-inflammatory
activities,
exhibited
prominent
capacity
in
targeting
cells
senomorphic
agent.
cells,
apigenin
blocks
interactions
between
ATM/p38
HSPA8,
thus
preventing
transition
acute
stress-associated
(ASAP)
towards
SASP.
Mechanistically,
targets
peroxiredoxin
6
(PRDX6),
an
intracellular
redox-active
molecule,
suppressing
iPLA2
activity
PRDX6
disrupting
downstream
reactions
underlying
SASP
development.
Without
reversing
cellular
senescence,
deprives
cancer
malignancy
acquired
from
stromal
culture,
while
reducing
chemoresistance
upon
combination
chemotherapy
anticancer
regimens.
preclinical
trials,
administration
improves
physical
function
animals
prematurely
aged
after
whole
body
irradiation,
alleviating
frailty
cognitive
impairment.
Overall,
our
study
demonstrates
potential
exploiting
naturally
derived
compound
achieve
geroprotective
modulating
SASP,
providing
research
platform
future
exploration
novel
agents
against
conditions.
Язык: Английский
Enhancing Transcriptomic Insights into Neurological Disorders Through the Comparative Analysis of Shapley Values
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(12), С. 13583 - 13606
Опубликована: Ноя. 29, 2024
Neurological
disorders
such
as
Autism
Spectrum
Disorder
(ASD),
Schizophrenia
(SCH),
Bipolar
(BD),
and
Major
Depressive
(MDD)
affect
millions
of
people
worldwide,
yet
their
molecular
mechanisms
remain
poorly
understood.
This
study
describes
the
application
Comparative
Analysis
Shapley
values
(CASh)
to
transcriptomic
data
from
nine
datasets
associated
with
these
complex
disorders,
demonstrating
its
effectiveness
in
identifying
differentially
expressed
genes
(DEGs).
CASh,
which
combines
Game
Theory
Bootstrap
resampling,
offers
a
robust
alternative
traditional
statistical
methods
by
assessing
contribution
each
gene
broader
context
complete
dataset.
Unlike
conventional
approaches,
CASh
is
highly
effective
at
detecting
subtle
but
meaningful
patterns
that
are
often
missed.
These
findings
highlight
potential
enhance
precision
analysis,
providing
deeper
understanding
underlying
establishing
solid
basis
improve
diagnostic
techniques
developing
more
targeted
therapeutic
interventions.
Язык: Английский
Multifaceted in-vitro and in-silico evaluation of Pimenta racemosa (Mill.) essential oil: A potential alternative source of eugenol
Industrial Crops and Products,
Год журнала:
2024,
Номер
223, С. 120246 - 120246
Опубликована: Дек. 10, 2024
Язык: Английский
Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew
Brain Sciences,
Год журнала:
2024,
Номер
14(12), С. 1296 - 1296
Опубликована: Дек. 23, 2024
Background/Objectives:
Military
aviators
can
be
exposed
to
extreme
physiological
stressors,
including
decompression
stress,
G-forces,
as
well
intermittent
hypoxia
and/or
hyperoxia,
which
may
contribute
neurobiological
dysfunction/damage.
This
study
aimed
investigate
the
levels
of
neurological
biomarkers
in
military
assess
potential
risk
long-term
brain
injury
and
neurodegeneration.
Methods:
cross-sectional
involved
48
Canadian
Armed
Forces
(CAF)
non-aviator
CAF
controls.
Plasma
samples
were
analyzed
for
glial
activation
(GFAP),
axonal
damage
(NF-L,
pNF-H),
oxidative
stress
(PRDX-6),
neurodegeneration
(T-tau),
along
with
S100b,
NSE,
UCHL-1.
The
biomarker
concentrations
quantified
using
multiplexed
immunoassays.
Results:
exhibited
significantly
elevated
GFAP,
NF-L,
PRDX-6,
T-tau
compared
controls
(p
<
0.001),
indicating
increased
activation,
injury,
stress.
Trends
toward
higher
UCHL-1
observed
but
not
statistically
significant.
suggest
cumulative
damage,
raising
concerns
about
impairments.
Conclusions:
are
at
early
These
findings
emphasize
importance
proactive
monitoring
further
research
understand
impacts
high-altitude
flight
on
health
develop
strategies
mitigating
cognitive
decline
neurodegenerative
risks
this
population.
Язык: Английский