End-to-End CT Radiomics-Based Pipeline for Predicting Renal Interstitial Fibrosis Grade in CKD Patients

Academic Radiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Safety of PD-L1 inhibitors versus PD-1 inhibitors in the treatment of lung cancer: a systematic review and network meta-analysis

Expert Review of Anticancer Therapy, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Background To explore the safety of PD-L1 inhibitors vs. PD-1 in extensive-stage small-cell lung cancer (ES-SCLC) and non-small-cell (NSCLC).

Язык: Английский

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Relationship between renal oxidative stress levels and disease severity in patients with chronic kidney disease assessed by [Cu-64]ATSM PET/MRI

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 28, 2025

The purpose of the study was to investigate renal oxidative stress (OS) and its relationship with disease severity in patients chronic kidney (CKD) using positron emission tomography coupled magnetic resonance imaging (PET/MRI), employing 64Cu-diacetyl-bis(N4-methylthiosemicarbazonate) (64Cu-ATSM) as PET tracer for OS imaging. Thirty CKD (66.4 ± 8.2 y.o.) seven healthy controls (HC) subjects (58.3 3.8 underwent 64Cu-ATSM PET/MRI. Participants were categorized into three groups based on their estimated glomerular filtration rate (eGFR): HC, mild (stages 2-3a), advanced 3b-5). All 30-min dynamic PET/MRI starting injection evaluate blood flow (RBF) levels. RBF (mL/min/100 g) images calculated from first 3 min data, standardized uptake value (SUV) obtained delayed frames 15-30 after injection. SUV corrected RBF-adjusted individual estimate levels kidneys following equation: adjusted index (aOSi) = (SUV/RBF)x100. Significant correlation observed between eGFR (r 0.81, P < 0.001). is significantly lower than that HC (P 0.001) 0.004). did not differ among 0.171). SUVs correlate creatinine or CKD. However, these values 0.33, 0.049) all subjects, whereas showed no significant correlation. Following correction, aOSi demonstrated correlations 0.75, 0.001), (r= -0.65, stages 0.57, subjects. This preliminary has revealed may provide a reasonably noninvasively. Increased correlated levels, suggesting increases dysfunction.

Язык: Английский

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Combating chronic kidney disease-associated cachexia: A literature review of recent therapeutic approaches

BMC Nephrology, Год журнала: 2025, Номер 26(1)

Опубликована: Март 11, 2025

In 2008, the Society on Sarcopenia, Cachexia, and Wasting Disorders introduced a generic definition for all types of cachexia: "a complex metabolic syndrome associated with underlying illness characterized by loss muscle, or without fat loss". It is well-known that presence inflammatory burden in end-stage renal disease (ESRD) patients may lead to evolution cachexia. Since etiology cachexia chronic kidney (CKD) multifactorial, thus successful treatment must involve several concomitant measures (nutritional interventions, appetite stimulants, anti-inflammatory pharmacologic agents) provide integrated effective therapeutic modalities combat causative factors alleviate outcomes patients. Given high mortality rate cachexia, developing new are prerequisite ameliorating CKD worldwide. The present review aims discuss some strategies an update advances nutritional approaches counteract

Язык: Английский

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The association between docosanoic acid and the risks of occurrence and mortality of chronic kidney disease

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Objective This study aims to investigate the association between docosanoic acid (DA) in human circulation and risk of occurrence mortality chronic kidney disease (CKD). Methods is a cross-sectional including individuals NHANES 2011-2014. RCS were used fit dose-effect curve DA levels CKD general population, patients. Multiple logistic Cox regressions analyze with risks respectively. Results A total 2,366 participants included this study, 1,958 (82.8%) without 408 (17.2%) individuals. The results showed linear Per standard deviation (per-SD) increase DA, population decreased by 18% (OR = 0.82; 95% CI, 0.70 - 0.96; P 0.02). In addition, cardiovascular all-cause CKD. Multivariate regression analysis that per-SD patients 44% (HR 0.56; 0.35 0.90; 0.02) 27% 0.73; 0.59 0.89; 0.002). Conclusion Higher serum populations means lower risk. Moreover, for patients, as increase, decreases.

Язык: Английский

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Progress in the application of novel inflammatory indicators in chronic kidney disease

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 30, 2025

Chronic kidney disease has become a public health problem endangering the of all humans because its high prevalence, mortality and medical burden. The chronic micro-inflammatory state is recognized as significant component CKD, playing key role in progression. Intervening inflammation during course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte systemic immune-inflammatory index are closely associated with meanwhile may serve prognostic monitors all-cause death poor renal prognosis for disease. This article comprehensively reports on mechanisms micro-inflammation relationship between indicators their impact

Язык: Английский

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Chronic Kidney Disease and Osteoarthritis: Current Understanding and Future Research Directions

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1567 - 1567

Опубликована: Фев. 13, 2025

Chronic kidney disease (CKD) is a significant public health concern. Osteoarthritis (OA), common form of arthritis, has been shown to have dramatically increased prevalence, particularly among individuals aged 40-50 and older, in the presence CKD. Furthermore, CKD may exacerbate progression impact OA. A survey study revealed that 53.9% patients undergoing long-term hemodialysis were diagnosed with These findings underscore potential association between Uremic toxins, such as indoxyl sulfate, p-cresyl transforming growth factor-β, advanced glycation end-products, are regarded risk factors various CKD-related conditions, affecting bone joint metabolism. However, whether these serve bridging mechanism OA comorbidities, well their detailed roles this context, remains unclear. Addressing identifying effective treatment prevention strategies an urgent challenge warrants immediate attention. This review focuses on describing discussing molecular pathological mechanisms underlying CKD-associated possible therapeutic strategies.

Язык: Английский

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Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 1609 - 1626

Опубликована: Март 1, 2025

Purpose: Vaccarin is a natural flavonoid glycoside with anti-inflammatory, antioxidant and nephroprotective effects. However, the effects of vaccarin on renal fibrosis (RF) its molecular mechanisms remain unclear. This study aimed to investigate RF mechanisms. Methods: Network pharmacology was used analyze effect RF, docking dynamics simulations were performed assess binding nuclear factor erythroid 2-related 2 (Nrf2) vaccarin. A mouse model unilateral ureteral obstruction (UUO) established in vivo, human tubular epithelial (HK2) cells induced transforming growth factor-β (TGF-β) RSL3, respectively, as an vitro model. The anti-fibrotic observed by histopathological staining determination fibrous markers. Changes oxidative stress ferroptosis-related markers detected kits, Western blot (WB), qRT-PCR immunofluorescence (IF). Finally, Nrf2 inhibitors added observe ferroptosis. Results: cross genes are enriched for stress. binds stably Both vivo experiments showed that treatment reduced expression markers, decreased levels reactive oxygen species (ROS), malondialdehyde (MDA), lipid peroxidation (LPO) Fe 2+ , increased glutathione (GSH) secretion. In addition, down-regulated Long-chain acyl-CoA synthetase 4 (ACSL4), prostaglandin-endoperoxide synthase (PTGS2) NADPH oxidase 1 (NOX1), up-regulated downstream solute transport family 7 member 11 (SLC7A11) peroxidase (GPX4) expression. Mechanistic studies indicated activated Nrf2/SLC7A11/GPX4 pathway inhibit ferroptosis, this inhibition effectively reversed inhibitor. Conclusion: ameliorates inhibiting ferroptosis via pathway. Keywords: vaccarin, fibrosis, pathway, stress, network

Язык: Английский

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Apitherapy for drug-induced kidney disease: a narrative review on its mechanisms

Journal of Complementary and Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Abstract Objectives The use of medications for the treatment various diseases often results in kidney damage. Apitherapy is a natural therapeutic tool with potential utility this purpose. This narrative review analyzes and summarizes scientific evidence on apitherapy drug-induced disease. Content recent advances disease explores, based available evidence, how can modify these mechanisms be utilized prevention treatment. Summary (the complementary integrative beehive products) potentially useful system diseases. examines preclinical clinical regarding its Outlook has effects pathophysiological disease, including oxidative stress, inflammation, decreased renal blood flow, glomerular damage, increased membrane permeability, activity renin-angiotensin-aldosterone axis, mitochondrial dysfunction, apoptosis. Further studies humans are needed to evaluate efficacy setting, but promising.

Язык: Английский

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Evaluation of renal oxidative stress in patients with chronic kidney disease using 64 Cu-ATSM PET/MRI

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

The purpose of the study was to investigate renal oxidative stress (OS) and its relationship with disease severity in patients chronic kidney (CKD) using positron emission tomography coupled magnetic resonance imaging (PET/MRI), employing ⁶⁴Cu-diacetyl-bis(N⁴-methylthiosemicarbazonate) (⁶⁴Cu-ATSM) as PET tracer for OS imaging. Thirty CKD (66.4 ± 8.2 y.o.) seven healthy controls (HC) subjects (58.3 3.8 underwent ⁶⁴Cu-ATSM PET/MRI. Participants were categorized into three groups based on their estimated glomerular filtration rate (eGFR): HC, mild (stages 2-3a), advanced 3b-5). All 30-min dynamic PET/MRI starting injection evaluate blood flow (RBF) levels. RBF (mL/min/100g) images calculated from first 3 min data, standardized uptake value (SUV) obtained delayed frames 15–30 after injection. SUV corrected individual estimate levels kidneys following equation: index = (SUV/RBF)x100. Significant correlation observed between eGFR (r 0.81, P < 0.001). is significantly lower than that HC (P 0.001) 0.004). did not differ among 0.171). SUVs correlate creatinine or CKD. However, these values 0.33, 0.049) all subjects, whereas showed no significant correlation. Following correction, demonstrated correlations 0.75, 0.001), (r= -0.65, stages 0.57, subjects. This preliminary has revealed may provide a reasonable reasonably noninvasively. Increased correlated levels, suggesting increases dysfunction.

Язык: Английский

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