Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 15, 2025
Acute
kidney
injury
(AKI)
has
become
a
disease
of
global
concern
due
to
its
high
morbidity
and
mortality.
This
highlighted
the
need
for
renoprotective
agents.
Astragaloside
IV
(AS-IV)
is
saponin
isolated
from
Astragalus
membranaceus
with
good
antioxidant,
anti-inflammatory
anti-tumor
properties.
In
this
study,
HK2
cells
rat
model
were
utilized
explore
protective
effect
AS-IV
against
cadmium
chloride-induced
oxidative
stress-induced
apoptosis.
CdCl2-induced
apoptosis,
ROS
production,
mitochondrial
membrane
potential
alterations
significantly
inhibited
in
-treated
cells.
Expression
mitochondria-associated
apoptotic
proteins
Cleaved-Caspase3,
Cleaved-Caspase9,
Cleaved-PARP
was
reduced
after
intervention.
addition,
Rat
weight
loss
also
alleviated
symptoms
nephrotoxicity
injury.
Further
experiments
showed
that
suppresses
heavy
metal
Cd-induced
mitochondria-mediated
apoptosis
by
regulating
Nrf2/HO-1
pathway.
conclusion,
could
protect
metal-induced
toxicity
be
used
as
nephroprotective
agent.
Язык: Английский
The Preventive Impact of Chokeberry (Aronia melanocarpa L.) Extract Regarding the Disruption of Calcium and Phosphorus Homeostasis and Chosen Pathways of Its Regulation in an Animal Model of General Population Exposure to Cadmium
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 702 - 702
Опубликована: Фев. 16, 2025
Background:
Our
previous
research
in
an
experimental
model
of
current
environmental
human
exposure
to
cadmium
(Cd)
(female
rats
fed
a
diet
containing
Cd
at
1
and
5
mg/kg
for
up
2
years)
revealed
that
chronic
treatment
with
this
toxic
element
destroyed
the
metabolism
bone
tissue,
decreased
mineralisation,
weakened
biomechanical
properties,
whereas
co-administration
0.1%
chokeberry
(Aronia
melanocarpa
L.
(Michx.)
Elliott
berry)
extract
(AME)
ameliorated
osteotoxic
action
Cd.
Methods:
In
study,
it
was
explored
whether
unfavourable
effect
protective
AME
might
be
mediated
by
impact
on
essential
elements
such
as
calcium
(Ca)
inorganic
phosphorus
(Pi),
including
pathways
its
regulation
calciotropic
hormones
(parathormone—PTH,
calcitonin—CT,
1,25-dihydroxyvitamin
D3—1,25(OH)2D3)
Klotho.
Results:
Low-level
(1
mg/kg)
caused
only
temporary
elevation
serum
PTH
concentration
decline
CT.
Moderate
(5
body
homeostasis
both
mineral
(lowered
their
concentrations
enhanced
urinary
loss),
influenced
Klotho
hormones,
well
reduced
25-hydroxyvitamin
D
1alpha-hydroxylase
(1alpha-OHase)
1,25(OH)2D3
kidney.
The
application
during
intoxication
improved
involved
maintaining
Ca
Pi
allowed
subjects
maintain
proper
levels
these
urine.
Conclusions:
conclusion,
low-to-moderate
may
exert
influencing
regulating
destroying
status
minerals.
It
seems
possible
mechanism
osteoprotective
involves
normalization
improvement
Pi.
This
study
provided
further
evidence
products
effective
strategy
counteracting
effects
Язык: Английский
Role of Anonychium africanum (Plantae, Fabaceae) in Metal Oxido-Inflammatory Response: Protection Evidence in Gonad of Male Albino Rat
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1028 - 1028
Опубликована: Авг. 24, 2024
Male
fertility
is
strongly
affected
by
the
overexpression
of
free
radicals
induced
heavy
metals.
The
aim
this
study
was
to
evaluate
potential
antioxidant,
anti-inflammatory,
and
gonado-protective
effects
natural
compounds.
Biochemical
morphological
assays
were
performed
on
male
albino
rats
divided
into
five
groups:
a
control
group
(water
only),
orally
exposed
metal
mixture
Pb-Cd-Hg-As
alone
three
groups
co-administered
an
aqueous
extract
Nigerian
medicinal
plant,
Anonychium
africanum
(Prosopis
africana,
PA),
at
different
concentrations
(500,
1000,
1500
mg/kg)
for
60
days.
significant
rise
in
testicular
weight,
bioaccumulation,
oxidative
stress,
pro-inflammatory
apoptotic
markers,
while
semen
analysis
indicated
lower
viability
decrease
normal
sperm
count,
plasma
reproductive
hormones
showed
variation.
Parallel
phytochemical
investigations
that
PA
has
bioactive
compounds
like
phlobatannins,
flavonoids,
polyphenols,
tannins,
saponins,
steroids,
alkaloids,
which
are
protective
against
injury
neural
tissues.
Indeed,
presence
with
mitigated
toxic
metals’
impact,
determined
observing
oxido-inflammatory
response
via
nuclear
factor
erythroid
2-related
2,
thus
boosting
health.
Язык: Английский
Metabolomic Analysis and Biochemical Profiling of Cadmium-Induced Metabolic Impairment and Its Amelioration by Resveratrol
Bioengineering,
Год журнала:
2024,
Номер
11(11), С. 1141 - 1141
Опубликована: Ноя. 13, 2024
Exposure
to
heavy
metals,
particularly
cadmium
(Cd),
poses
significant
health
risks
because
of
their
toxic
effects
and
potential
for
bioaccumulation
in
living
organisms.
This
study
examined
the
biochemical
metabolomic
changes
induced
by
Cd
exposure
an
animal
model
via
advanced
liquid
chromatography
with
tandem
mass
spectrometry
(LC-MS/MS)
assays
reveal
disruptions
lipid
amino
acid
metabolism
as
well
alterations
key
metabolic
pathways.
led
weight
loss,
hyperglycemia,
insulin
resistance,
indicating
its
role
disorders
such
diabetes.
The
accumulation
liver
kidneys,
identified
ICP-OES,
corresponded
elevated
levels
(ALT,
AST)
kidney
(BUN,
creatinine)
biomarkers,
suggesting
organ-specific
toxicity.
At
level,
caused
metabolites
ceramides
sphingolipids,
which
are
associated
resistance
broader
impairments.
Amino
was
also
significantly
disrupted,
increased
concentrations
acids
phenylalanine,
tryptophan,
arginine
affecting
pathways
urea
cycle
Krebs
cycle.
These
disturbances
linked
oxidative
stress,
systemic
inflammation,
impaired
glucose
regulation,
evidenced
CRP
IL-6
levels.
protective
resveratrol
(RSV)
were
clearly
demonstrated
this
study.
RSV
treatment
ameliorated
Cd-induced
alterations,
shown
improved
glycemic
control,
restored
profiles,
normalized
concentrations.
Additionally,
reduced
inflammatory
markers
function,
highlighting
antioxidant
properties
a
therapeutic
agent
against
However,
did
not
reduce
organs,
that
related
mitigating
damage
disruption
rather
than
promoting
excretion.
enhances
our
understanding
molecular
mechanisms
underlying
impairments
highlights
combating
findings
underscore
need
further
research
into
metal
mitigation
protect
human
health,
areas
environmental
contamination.
Язык: Английский