Food Chemistry X,
Год журнала:
2024,
Номер
24, С. 101947 - 101947
Опубликована: Ноя. 2, 2024
As
a
potent
naturally
carotenoid,
Astaxanthin
(AST)
is
commonly
used
as
natural
coloring
agent
and
antioxidant
in
food
products,
it's
stability
of
great
interest.
The
AST
solution
stored
glass
bottle
under
different
temperatures
ultraviolet
(UV)
irradiation
durations
was
analyzed
situ
using
confocal
Raman
spectroscopy,
the
acceptable
depth
focus
optimized.
spectra
geometrical
isomers
were
determined
by
density
functional
theory
(DFT)
simulation,
characteristic
peaks
selected
for
studying
degradation
isomerization.
peak-fitting
based
on
gaussian
multi-peak
fitting
analysis
combined
with
Pearson's
correlation
conducted
to
study
effect
UV
peak
intensity
ratio
I
PLoS ONE,
Год журнала:
2025,
Номер
20(1), С. e0318005 - e0318005
Опубликована: Янв. 27, 2025
Oxidative
damage,
oxidative
inflammation,
and
a
range
of
downstream
diseases
represent
significant
threats
to
human
health.
The
application
natural
antioxidants
anti-inflammatory
agents
can
help
prevent
mitigate
these
associated
diseases.
In
this
study,
we
aimed
investigate
the
effectiveness
walnut
green
husk
(WNGH)
as
an
antioxidant
agent
in
vitro
setting.
HepG2
cells
were
treated
with
tert-butyl
hydroperoxide
(t-BHP)
establish
cellular
model
damage
inflammation.
We
assessed
biocompatibility
aqueous
extract
(WNGH-AE)
on
using
MTT
LDH
assays
(WNGH-AE
concentration:
0.05,
0.1,
0.2,
0.4,
0.8,
1.6,
3.2,
6.4,
12.8
mg/mL).
Additionally,
measured
intracellular
stress
indicators,
such
ROS
8-OHdG,
along
inflammatory
factors
TNF-α
IL-1β
through
ELISA
evaluate
capacity
WNGH-AE
(concentration:
0.025,
0.1
mg/mL)
cells.
also
determined
free
radical
scavenging
various
extracts
WNGH
DPPH
·OH
methods.
total
phenols,
polysaccharides,
flavonoids
analyzed
Folin-Ciocalteu’s
reagent,
phenol-sulfuric
acid
method,
spectrophotometry,
respectively.
bioactive
components
LC-MS/MS.
Our
results
demonstrated
that
was
highly
biocompatible
effect
involved
ROS,
while
its
linked
down-regulation
NF-κB
pathway.
Compared
other
extractants
(ethyl
acetate,
n-butanol,
75%
ethanol,
petroleum
ether),
exhibited
strongest
ability.
Through
LC-MS/MS
analysis,
identified
403
compounds
WNGH-AE,
gentisic
being
most
abundant
possessing
high
capacity,
suggesting
it
may
be
key
active
component
contributing
activity
WNGH-AE.
conclusion,
our
findings
indicate
is
natural,
high-quality
biomaterial
deserving
further
research
development,
potential
applications
healthcare.
(311
words)
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 35
Опубликована: Фев. 24, 2025
Microalgae
are
rich
sources
of
astaxanthin
well
recognized
for
their
potent
bioactivities
such
as
antioxidant,
anti-cancer,
and
anti-inflammatory
activities.
Recent
interests
focused
on
the
microalgae-derived
treating
or
preventing
cancers
mediated
by
antioxidant
properties.
This
is
due
to
special
structural
configuration
in
terms
unsaturation
(conjugated
double
bonds),
stereochemical
isomerism
(3S,3'S
optical
isomer)
esterification
(monoester),
which
display
more
bioactivities,
compared
with
those
from
other
natural
yeasts
higher
plants,
synthetic
astaxanthin.
review
focuses
recent
advances
association
immune
diseases,
emphasis
potential
applications
antioxidants.
Various
well-developed
biotechnological
approaches
inducing
production
microalgal
culture,
along
proven
emerging
industrial
technologies
commercialize
products
a
large-scale
manner,
also
critically
reviewed.
These
would
facilitate
manufacture
bioactive
be
applied
food
pharmaceutical
industries
salutary
nutraceuticals.
Marine Drugs,
Год журнала:
2025,
Номер
23(4), С. 143 - 143
Опубликована: Март 26, 2025
Herein,
the
effectiveness
of
astaxanthin
(AX)
as
functional
feed
ingredient
was
assessed
by
enhancing
its
stability
and
bioavailability
using
encapsulation
methods.
Spray-drying
liposome
entrapment
were
applied
to
a
natural
AX
source
from
shrimp
by-products,
along
with
two
commercially
synthetic
alternatives.
Encapsulated
formulations
evaluated
for
their
physico-chemical
properties,
thermal
stability,
in
vitro
performance
RTL-W1,
rainbow
trout
(Oncorhynchus
mykiss)
liver-derived
cell
line.
Both
techniques
achieved
high
efficiency
(73-89%)
provided
remarkable
protection
during
treatments,
maintaining
at
80
°C
up
2
h
100
30
min.
Nevertheless,
neither
methods
significantly
mitigated
water
absorption
over
time.
Additionally,
morphological
characterization
revealed
spray-dried
microcapsules
typical
round,
partially
collapsed
particles
broad
size
distribution,
while
liposomes
further
stabilized
into
dry
powders
spray-drying
showed
structural
rearrangements
an
increase
upon
rehydration,
although
uniform
stable
distribution.
In
testing
enhanced
RTL-W1
viability
reduced
reactive
oxygen
species
(ROS)
production
when
employed.
Overall,
these
findings
demonstrate
potential
selected
optimize
bioavailability,
functionality
AX,
providing
valuable
insights
improve
utilization
fish
formulations.
Fishes,
Год журнала:
2025,
Номер
10(4), С. 159 - 159
Опубликована: Апрель 4, 2025
Astaxanthin,
a
xanthophyll
carotenoid,
exhibits
potent
biological
functions,
including
antioxidant,
immune
regulation,
growth
promotion,
improved
reproductive
capacity,
and
enhancement
of
the
body
color
aquatic
animals.
In
recent
years,
with
rapid
development
aquaculture
industry,
application
astaxanthin
in
has
garnered
increasing
attention.
Studies
have
demonstrated
that
significantly
enhances
antioxidant
capacity
animals,
reduces
oxidative
damage,
regulates
expression
immune-related
genes,
thereby
improving
immunity
disease
resistance.
Moreover,
promotes
performance,
particularly
high-value
species,
where
it
also
serves
as
natural
pigment
to
increase
market
competitiveness.
However,
low
bioavailability
high
production
costs
remain
major
constraints
its
widespread
use
aquaculture.
To
address
these
limitations,
various
strategies—such
microencapsulation,
liposomal
delivery,
nanotechnology—have
been
explored
improve
stability
water
solubility.
Additionally,
expanding
sources
optimizing
processes
are
effective
approaches
reducing
costs.
This
review
summarizes
advances
research
within
aquaculture,
highlights
multifunctional
roles
promoting
health
efficiency
discusses
current
challenges
future
directions.
