The Underestimated Role of Iron in Frontotemporal Dementia: A Narrative Review DOI Open Access

Sara Ferretti,

Isabella Zanella

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12987 - 12987

Опубликована: Дек. 3, 2024

The term frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders characterized by the progressive degeneration frontal and temporal lobes brain with language impairment changes in cognitive, behavioral executive functions, some cases motor manifestations. A high proportion FTD are due to genetic mutations inherited an autosomal-dominant manner variable penetrance depending on implicated gene. Iron is crucial microelement that involved several cellular essential functions whole body plays additional specialized roles central nervous system (CNS) mainly through its redox-cycling properties. Such feature may be harmful under aerobic conditions, since it lead generation highly reactive hydroxyl radicals. Dysfunctions iron homeostasis CNS indeed disorders, although still challenging determine whether dyshomeostasis this but metal direct cause neurodegeneration, contributor factor or simply consequence other mechanisms. Unlike many evidence dysfunction scarce; nonetheless, recent literature intriguingly suggests possible involvement. present review aims summarize what currently known about contribution based clinical, imaging, histological, biochemical molecular studies, further suggesting new perspectives offering insights for future investigations underexplored field research.

Язык: Английский

Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders DOI
Azhagu Madhavan Sivalingam,

Darshitha D Sureshkumar

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

1
Rapid and Efficient Synthesis of Succinated Thiol Compounds via Maleic Anhydride Derivatization DOI Creative Commons
Hiroshi Yamaguchi,

Hikari Sugawa,

Himeno Takahashi

и другие.

Molecules, Год журнала: 2025, Номер 30(3), С. 571 - 571

Опубликована: Янв. 27, 2025

Succination is a non-enzymatic post-translational modification of cysteine (Cys) residues, resulting in the formation S-(2-succino)cysteine (2SC). While hundreds 2SC-modified proteins have been identified and are associated with dysfunction proteins, underlying molecular mechanisms remain poorly understood. Conventional methods for synthesizing succinated compounds, such as 2SC, often require prolonged reaction times and/or HCl hydrolysis. In this study, we present rapid efficient synthesis method compounds using maleic anhydride, enabling more effective vivo studies succination mechanisms. This was tested on thiol varying weights, including Cys derivatives, Cys-containing peptides, reduced bovine serum albumin. By incubating these an aqueous buffer anhydride dissolved organic solvent like diethyl ether, achieved significantly improved efficiency compared to conventional methods. The surpassed that fumaric acid or acid. Notably, approach facilitated amino acids, within minutes at 25 °C, without requiring Our findings provide straightforward, time-efficient strategy offering valuable tool enhance understanding succination’s its role protein function dysfunction.

Язык: Английский

Процитировано

0
The Underestimated Role of Iron in Frontotemporal Dementia: A Narrative Review DOI Open Access

Sara Ferretti,

Isabella Zanella

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12987 - 12987

Опубликована: Дек. 3, 2024

The term frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders characterized by the progressive degeneration frontal and temporal lobes brain with language impairment changes in cognitive, behavioral executive functions, some cases motor manifestations. A high proportion FTD are due to genetic mutations inherited an autosomal-dominant manner variable penetrance depending on implicated gene. Iron is crucial microelement that involved several cellular essential functions whole body plays additional specialized roles central nervous system (CNS) mainly through its redox-cycling properties. Such feature may be harmful under aerobic conditions, since it lead generation highly reactive hydroxyl radicals. Dysfunctions iron homeostasis CNS indeed disorders, although still challenging determine whether dyshomeostasis this but metal direct cause neurodegeneration, contributor factor or simply consequence other mechanisms. Unlike many evidence dysfunction scarce; nonetheless, recent literature intriguingly suggests possible involvement. present review aims summarize what currently known about contribution based clinical, imaging, histological, biochemical molecular studies, further suggesting new perspectives offering insights for future investigations underexplored field research.

Язык: Английский

Процитировано

0