Wolfberry Honey and Its Extract Alleviate Dextran Sodium Sulfate‐Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Reducing Oxidative Stress and Inflammation DOI Open Access
Jie Yuan, Qian Wu, Yuyang Guo

и другие.

Molecular Nutrition & Food Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Inflammatory bowel disease (IBD) is a chronic condition characterized by gut inflammation causing persistent diarrhea and abdominal pain. Despite the nutritional benefits of wolfberry honey (from Lycium barbarum L.), its potential to alleviate IBD remains underexplored. This study evaluated protective effects extract (wolfberry [WHE]) against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) using in vivo vitro models. Mice pretreated with showed significant symptom improvement DSS-induced UC, linked reduced expression proinflammatory markers (Il-1β, Il-6, Tnf-α, Mcp-1) increased antioxidant genes (Nrf2, Sod2). Increased Occludin levels indicated improved intestinal barrier function. In vitro, WHE protected DSS-treated Caco-2 cells lowering reactive oxygen species (ROS), stabilizing mitochondrial membrane potential, inhibiting TLR4/NF-κB signaling. It enhanced tight junction proteins (ZO-1, Occludin, Claudin-1). Metabolomic analysis revealed that modulated glycerophospholipid metabolism, increasing phosphatidylcholine choline decreasing lysophosphatidylcholine levels. These results highlight as nutraceuticals for managing UC through their on inflammation, oxidative stress, Further research warranted elucidate mechanisms action assess long-term therapeutic management.

Язык: Английский

Novel Insight into the Composition Differences Between Buffalo and Holstein Milk and Potential Anti-Inflammation and Antioxidant Effect on Caco-2 Cells DOI Creative Commons

Luyao Wang,

Xinyue Hu,

Jiaqi Jiang

и другие.

Foods, Год журнала: 2024, Номер 13(23), С. 3915 - 3915

Опубликована: Дек. 4, 2024

Milk is one of the most common sources nutrients in humans, however, composition and healthy value milk derived from different animals are very different. Here, we systemically compared protein lipid profiles evaluated anti-inflammation antioxidant effect buffalo Holstein-derived on Caco-2 cells. Results showed that 906 proteins 1899 lipids were identified Holstein samples including 161 significantly (DEPs) 49 lipids. The DEPs mainly enriched defense response-related terms, while differential included fat digestion absorption cholesterol metabolism pathways. In addition, cells co-cultured with components significant benefits being resistant to LPS-induced inflammation stress H

Язык: Английский

Процитировано

0
Wolfberry Honey and Its Extract Alleviate Dextran Sodium Sulfate‐Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Reducing Oxidative Stress and Inflammation DOI Open Access
Jie Yuan, Qian Wu, Yuyang Guo

и другие.

Molecular Nutrition & Food Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Inflammatory bowel disease (IBD) is a chronic condition characterized by gut inflammation causing persistent diarrhea and abdominal pain. Despite the nutritional benefits of wolfberry honey (from Lycium barbarum L.), its potential to alleviate IBD remains underexplored. This study evaluated protective effects extract (wolfberry [WHE]) against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) using in vivo vitro models. Mice pretreated with showed significant symptom improvement DSS-induced UC, linked reduced expression proinflammatory markers (Il-1β, Il-6, Tnf-α, Mcp-1) increased antioxidant genes (Nrf2, Sod2). Increased Occludin levels indicated improved intestinal barrier function. In vitro, WHE protected DSS-treated Caco-2 cells lowering reactive oxygen species (ROS), stabilizing mitochondrial membrane potential, inhibiting TLR4/NF-κB signaling. It enhanced tight junction proteins (ZO-1, Occludin, Claudin-1). Metabolomic analysis revealed that modulated glycerophospholipid metabolism, increasing phosphatidylcholine choline decreasing lysophosphatidylcholine levels. These results highlight as nutraceuticals for managing UC through their on inflammation, oxidative stress, Further research warranted elucidate mechanisms action assess long-term therapeutic management.

Язык: Английский

Процитировано

0